BMC Immunology, 2020 Background Numerous data obtained by different research laboratories indicate that specific IgE production is triggered independently of specific IgG or IgA ones and so it is not linked to fully matured germinal centers formation in the secondary ...
Dmitrii Borisovich Chudakov +5 more
doaj +3 more sources
Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer. [PDF]
Br J Cancer, 2015 Background:Host immunity has critical roles in tumour surveillance. Tertiary lymphoid organs (TLOs) are induced in various inflamed tissues. The aim of this study was to investigate the clinicopathological and pathobiological characteristics of tumour ...
Hiraoka N +5 more
europepmc +2 more sources
Tertiary lymphoid organ-associated transcriptomic features predict rejection and outcome in kidney transplantation: integrative analysis and experimental validation. [PDF]
Clin Exp MedBackground Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in chronically inflamed tissues, including renal allografts. While increasingly recognized in kidney transplant biopsies, the molecular features, clinical significance,
Shen X +5 more
europepmc +2 more sources
S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum. [PDF]
J Exp MedTLOs are LN-like structures that are observed in certain inflammatory diseases. Geng et al. demonstrate that S1PR1 activity in the lymphatic vasculature is necessary to prevent TLO formation in the terminal ileum.
Geng X +19 more
europepmc +2 more sources
Stromal fibroblasts in tertiary lymphoid structures: a novel target in chronic inflammation. [PDF]
Frontiers in Immunology, 2016 Tertiary lymphoid structures (TLS) are organized aggregates of lymphocytes, myeloid and stromal cells that provide ectopic hubs for acquired immune responses.
Francesca Barone +5 more
doaj +5 more sources
Renal interstitial infiltration and tertiary lymphoid organ neogenesis in IgA nephropathy. [PDF]
Clin J Am Soc Nephrol, 2014 Previous studies have identified inflammatory features that enable the prediction of renal outcome of IgA nephropathy (IgAN); however, validation of these findings is still needed. This prospective study was performed to determine the characteristics of renal interstitial infiltration and tertiary lymphoid organ (TLO) neogenesis in a cohort of Chinese ...
Pei G +11 more
europepmc +4 more sources
Editorial: tertiary lymphoid organs (TLOs): powerhouses of disease immunity [PDF]
Frontiers in Immunology, 2017 No abstract ...
Habenicht, Andreas J.R. +3 more
core +9 more sources
Tertiary lymphoid organs in central nervous system autoimmunity [PDF]
Frontiers in Immunology, 2016 Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS), which results in permanent neuronal damage and substantial disability in patients.
Mitsdoerffer, M., Peters, A.
core +7 more sources
Frontiers in Immunology, 2023 In response to inflammatory stimuli in conditions such as autoimmune disorders, infections and cancers, immune cells organize in nonlymphoid tissues, which resemble secondary lymphoid organs.
Meiying Wang +13 more
doaj +2 more sources
Antigen-presenting cells and antigen presentation in tertiary lymphoid organs [PDF]
Frontiers in Immunology, 2016 Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures.
Bedaj, Marija +3 more
core +8 more sources