Results 21 to 30 of about 58,085 (320)

Spoiling for a Fight: B Lymphocytes As Initiator and Effector Populations within Tertiary Lymphoid Organs in Autoimmunity and Transplantation [PDF]

Frontiers in Immunology, 2017
Tertiary lymphoid organs (TLOs) develop at ectopic sites within chronically inflamed tissues, such as in autoimmunity and rejecting organ allografts. TLOs differ structurally from canonical secondary lymphoid organs (SLOs), in that they lack a mantle ...
Jawaher Alsughayyir, Gavin J. Pettigrew, Reza Motallebzadeh, Reza Motallebzadeh, Reza Motallebzadeh   +4 more
doaj   +3 more sources

From Lymphotoxin to Tertiary Lymphoid Structures and Beyond. [PDF]

Immunol Rev
Lymphoid organ development occurs in ontogeny in the absence of antigenic stimulation; inflammation occurs after some immunological insult. These subjects had originally been considered as separate fields of research.
Ruddle NH.
europepmc   +2 more sources

Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes [PDF]

Diabetologia, 2021
We and others previously reported the presence of tertiary lymphoid organs (TLOs) in the pancreas of NOD mice, where they play a role in the development of type 1 diabetes.
É. Korpos, N. Kadri, Sophie Loismann, Clais R. Findeisen, F. Arfuso, G. Burke, S. Richardson, N. Morgan, M. Bogdani, A. Pugliese, L. Sorokin   +10 more
semanticscholar   +4 more sources

Aberrant B cell responses as drivers of autoantibody generation and epitope diversification in SLE pathogenesis [PDF]

Frontiers in Immunology
Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease characterised by loss of tolerance, widespread immune dysregulation, and production of diverse autoantibodies (typically directed against nuclear components).
Fareeha Tariq, Fareeha Tariq, Yathavi Charavanmuttu, Kazi Labiba, Chris Wincup, Chris Wincup   +5 more
doaj   +2 more sources

Lymphotoxin β receptor and tertiary lymphoid organs shape acute and chronic allograft rejection

JCI Insight
Solid organ transplantation remains the life-saving treatment for end-stage organ failure, but chronic rejection remains a major obstacle to long-term allograft outcomes and has not improved substantially.
Gang Zhang, Neda Feizi, Daqiang Zhao, Latha Halesha, Amanda L. Williams, Parmjeet S. Randhawa, Khodor I. Abou-Daya, Martin H. Oberbarnscheidt   +7 more
doaj   +2 more sources

Spatial immunoprofiling of retroperitoneal leiomyosarcomas reveals intratumoral heterogeneity in immune cell infiltration, checkpoint molecule expression, and tertiary lymphoid structures [PDF]

Annals of Medicine
Introduction Leiomyosarcoma (LMS) is a rare, aggressive cancer with limited treatment options at the metastatic stage. The response to immune checkpoint inhibitors (ICIs) is inconsistent, likely due to intratumoral heterogeneity, which is more pronounced
Iva Benesova, Jan Balko, Vira Tovazhnianska, Michal Rataj, Robert Lischke, Jirina Bartunkova, Katerina Kopeckova, Tomas Buchler, Winan van Houdt, Yvonne Schrage, David Moura, Javier Martin Broto, Zuzana Ozaniak Strizova, Andrej Ozaniak   +13 more
doaj   +2 more sources

The atypical chemokine receptor 2 reduces T cell expansion and tertiary lymphoid tissue but does not limit autoimmune organ injury in lupus-prone B6lpr mice

Frontiers in Immunology
IntroductionThe atypical chemokine receptor 2 (ACKR2) is a chemokine scavenger receptor, which limits inflammation and organ damage in several experimental disease models including kidney diseases.
Wenkai Xia, Wenkai Xia, Nuru Eltrich, Volker Vielhauer   +3 more
doaj   +2 more sources

IL-17 initiates tertiary lymphoid organ formation. [PDF]

Cell Mol Immunol, 2012
Chronic inflammatory infiltrates that take on the form of organized lymphoid organs are called tertiary lymphoid organs (TLOs). The inflammatory cytokine interleukin-17 is now found to be the critical participant driving the development of a type of TLO called inducible bronchus-associated lymphoid tissue (iBALT) in an animal model of neonatal ...
Zhang X, Lu B.
europepmc   +4 more sources

Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections

Advanced Science
Tertiary lymphoid structure (TLS) is associated with various pathologies, including those of cancers and chronic infections. Depending on the organ, multiple factors regulate the formation of TLS.
Ruiqi Li, Fan Gu, Linlin Peng, Tingting Huan, Zhuo Zhou, Yaling Song, Jinmei He, Kaili Ye, Yao Sun, Tiejun Li, Miao He, Zhuan Bian, Wei Yin   +12 more
doaj   +2 more sources

Lymphoid Neogenesis and Tertiary Lymphoid Organs in Transplanted Organs [PDF]

Frontiers in Immunology, 2016
The progressive organization of immune effectors into functional ectopic lymphoid structures, named tertiary lymphoid organs (TLO), has been observed in many conditions in which target antigens fail to be eliminated by the immune system. Not surprisingly, TLO have been recurrently identified in chronically rejected allografts.
Koenig, Alice, Thaunat, Olivier
openaire   +2 more sources