Tertiary Lymphoid Organs in Central Nervous System Autoimmunity [PDF]
Frontiers in Immunology, 2016 Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS), which results in permanent neuronal damage and substantial disability in patients.
Meike Mitsdoerffer +2 more
doaj +10 more sources
Antigen Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs [PDF]
Frontiers in Immunology, 2016 Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterised by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures.
Catherine Hughes +5 more
doaj +11 more sources
Tertiary lymphoid organs in Takayasu Arteritis [PDF]
Frontiers in Immunology, 2016 Objective: The role of B cells in the pathogenesis of Takayasu arteritis (TA) is controversial. We aimed to study the presence of tertiary lymphoid organs (TLOs) in the aortic wall of TA patients.Methods: Hematoxylin and eosin–stained sections from aorta
Marc eClement +15 more
doaj +5 more sources
Editorial: Tertiary Lymphoid Organs (TLOs): Powerhouses of Disease Immunity. [PDF]
Front Immunol, 2017 No abstract ...
Yin C +3 more
europepmc +11 more sources
Artery Tertiary Lymphoid Organs: Powerhouses of Atherosclerosis Immunity [PDF]
Frontiers in Immunology, 2016 Artery tertiary lymphoid organs (ATLOs) are atherosclerosis-associated lymphoid aggregates with varying degrees of complexity ranging from small T/B-cell clusters to well structured lymph node-like though unencapsulated lymphoid tissues.
Changjun Yin +6 more
doaj +6 more sources
Graph-based description of tertiary lymphoid organs at single-cell level. [PDF]
PLoS Computational Biology, 2020 Our aim is to complement observer-dependent approaches of immune cell evaluation in microscopy images with reproducible measures for spatial composition of lymphocytic infiltrates.
Nadine S Schaadt +7 more
doaj +7 more sources
Tertiary lymphoid organs in systemic autoimmune diseases: pathogenic or protective? [version 1; referees: 2 approved] [PDF]
F1000Research, 2017 Tertiary lymphoid organs are found at sites of chronic inflammation in autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.
William D. Shipman +2 more
doaj +5 more sources
Spoiling for a Fight: B Lymphocytes As Initiator and Effector Populations within Tertiary Lymphoid Organs in Autoimmunity and Transplantation [PDF]
Frontiers in Immunology, 2017 Tertiary lymphoid organs (TLOs) develop at ectopic sites within chronically inflamed tissues, such as in autoimmunity and rejecting organ allografts. TLOs differ structurally from canonical secondary lymphoid organs (SLOs), in that they lack a mantle ...
Jawaher Alsughayyir +4 more
doaj +5 more sources
Investigating mammary glands of lactating goats for the presence of tertiary lymphoid organs [PDF]
Frontiers in Immunology, 2022 Ectopic tertiary lymphoid organs (TLOs) have been identified in many organs, such as the lungs, nasal cavities, and kidneys of both mice and humans. Although lymphocyte aggregates have been observed in the mammary glands of ruminants, the details remain ...
Yusaku Tsugami +4 more
doaj +2 more sources
Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease? [PDF]
Frontiers in Immunology, 2017 Secondary lymphoid organs are integral to initiation and execution of adaptive immune responses. These organs provide a setting for interactions between antigen-specific lymphocytes and antigen-presenting cells recruited from local infected or inflamed ...
Emily Jayne Colbeck +3 more
doaj +7 more sources