Tertiary Lymphoid Organs in Cancer Immunology: Mechanisms and the New Strategy for Immunotherapy [PDF]
Frontiers in Immunology, 2019 The immune system plays pivotal roles in the occurrence and progression of cancers. As blockade of immune-checkpoint has been proven effective at improving anti-tumor immune response in multiple tumor types, the tumor immunotherapy still faces many ...
Liangbin Lin +3 more
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Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors [PDF]
Journal for ImmunoTherapy of Cancer, 2019 Background Programmed cell death 1 inhibitors have revolutionized therapy for cancer by their outstanding effectiveness. However, they may cause adverse effects, among which inflammatory myopathy is one of the most disabling.
Shiro Matsubara +4 more
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Characteristics and Prognostic Value of Tertiary Lymphoid Organs in Membranous Nephropathy: A Retrospective Study [PDF]
Frontiers in Medicine, 2022 BackgroundTertiary lymphoid organs play an essential role in the inflammation of the kidney. The clinical association between TLOs and membranous nephropathy (MN) is not clear yet.MethodsConsecutive patients with the histologically confirmed membranous ...
Zu-feng Wang +5 more
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Chronic Inflammation: A Common Promoter in Tertiary Lymphoid Organ Neogenesis
Frontiers in Immunology, 2019 Tertiary lymphoid organs (TLOs) frequently develop locally in adults in response to non-resolving inflammation. Chronic inflammation leads to the differentiation of stromal fibroblast cells toward lymphoid tissue organizer-like cells, which interact with
Shanshan Luo +7 more
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Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice. [PDF]
Arterioscler Thromb Vasc Biol, 2016 Objective: Explore aorta B cell immunity in aged ApoE-/- mice. Approach and Results: Transcript maps, FACS, immunofluorescence analyses, cell transfers, and Ig-ELISPOT assays showed multi-layered atherosclerosis B cell responses in artery tertiary ...
Srikakulapu P +12 more
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Lymphotoxin β receptor and tertiary lymphoid organs shape acute and chronic allograft rejection [PDF]
JCI InsightSolid organ transplantation remains the life-saving treatment for end-stage organ failure, but chronic rejection remains a major obstacle to long-term allograft outcomes and has not improved substantially.
Gang Zhang +7 more
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Massive B-Cell Infiltration and Organization Into Artery Tertiary Lymphoid Organs in the Aorta of Large Vessel Giant Cell Arteritis [PDF]
Frontiers in Immunology, 2019 Giant cell arteritis (GCA) can be classified into Cranial(C)-GCA and Large Vessel(LV)-GCA. Based on analysis of temporal arteries, GCA is postulated to be T-cell-mediated.
Jacoba C. Graver +6 more
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Gel-trapped lymphorganogenic chemokines trigger artificial tertiary lymphoid organs and mount adaptive immune responses in vivo [PDF]
Frontiers in Immunology, 2016 We previously generated artificial lymph node-like tertiary lymphoid organs (artTLOs) in mice using lymphotoxin α-expressing stromal cells. Here, we show the construction of transplantable and functional artTLOs by applying soluble factors trapped in ...
Takeshi Watanabe
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Development and function of secondary and tertiary lymphoid organs in the small intestine and the colon [PDF]
Frontiers in Immunology, 2016 The immune system of the gut has evolved a number of specific lymphoid structures that contribute to homeostasis in the face of microbial colonization and food-derived antigenic challenge. These lymphoid organs encompass Peyer’s patches (PP) in the small
Manuela Buettner, Matthias Lochner
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High Endothelial Venules and Lymphatic Vessels in Tertiary Lymphoid Organs: Characteristics, Functions, and Regulation [PDF]
Frontiers in Immunology, 2016 High endothelial venules (HEVs) and lymphatic vessels (LVs) are essential for the function of the immune system, by providing communication between the body and lymph nodes (LNs), specialized sites of antigen presentation and recognition.
Nancy H Ruddle
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