Results 71 to 80 of about 9,564 (122)

Tertiary Lymphoid Organs (TLOs): Powerhouses of Disease Immunity

, 2017
The immune system employs TLOs to elicit highly localized and forceful responses to unresolvable peripheral tissue inflammation. Current data indicate that TLOs are protective but they may also lead to collateral tissue injury and serve as nesting places to generate autoreactive lymphocytes.
Changjun Yin, Andreas J.R. Habenicht, Pasquale Maffia, Sarajo Mohanta   +3 more
openaire   +3 more sources

Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances

Signal Transduction and Targeted Therapy
Tertiary lymphoid structures (TLSs) are defined as lymphoid aggregates formed in non-hematopoietic organs under pathological conditions. Similar to secondary lymphoid organs (SLOs), the formation of TLSs relies on the interaction between lymphoid tissue ...
Lianyu Zhao, Song Jin, Shengyao Wang, Zhe Zhang, Xuan Wang, Zhanwei Chen, Xiaohui Wang, Shengyun Huang, Dongsheng Zhang, Haiwei Wu   +9 more
doaj   +1 more source

Absence of sympathetic innervation hampers the generation of tertiary lymphoid structures upon acute lung inflammation

Scientific Reports
Tertiary lymphoid structures (TLS) are lymphoid organs present in inflammatory non-lymphoid tissues. Studies have linked TLS to favorable outcomes for patients with cancers or infectious diseases, but the mechanisms underlying their formation are not ...
Clémence Riffard, Laïla Letaïef, Safa Azar, Armanda Casrouge, Isabelle Brunet, Jean-Luc Teillaud, Marie-Caroline Dieu-Nosjean   +6 more
doaj   +1 more source

Tertiary lymphoid structures in head and neck squamous cell carcinoma

Translational Oncology
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Smoking, drinking, and human papillomavirus (HPV) infection are the main risk factors.
Jing Zhu, Hui Lu, Kongcheng Wang, Baorui Liu, Jing Yan   +4 more
doaj   +1 more source

Characteristics and Prognostic Value of Tertiary Lymphoid Organs in Membranous Nephropathy: A Retrospective Study. [PDF]

Front Med (Lausanne), 2021
Wang ZF, Cheng YC, Li YQ, Liu L, Ge SW, Xu G.   +5 more
europepmc   +1 more source

Tertiary lymphoid organs are associated with the progression of kidney damage and regulated by interleukin-17A. [PDF]

Theranostics, 2021
Luo R, Cheng Y, Chang D, Liu T, Liu L, Pei G, Zhang N, Wang Z, Guo K, Chen W, Li M, Fan L, Zhang C, Li Y, Dai W, Zuo M, Xu Y, Yao Y, Ge S, Xu G.   +19 more
europepmc   +1 more source

Ileitis-associated tertiary lymphoid organs arise at lymphatic valves and impede mesenteric lymph flow in response to tumor necrosis factor. [PDF]

Immunity, 2021
Czepielewski RS, Erlich EC, Onufer EJ, Young S, Saunders BT, Han YH, Wohltmann M, Wang PL, Kim KW, Kumar S, Hsieh CS, Scallan JP, Yang Y, Zinselmeyer BH, Davis MJ, Randolph GJ.   +15 more
europepmc   +1 more source

Editorial: Immune Outposts on the Inflammatory Frontier: Tertiary Lymphoid Structures as Targets for Immunotherapy of Cancer and Autoimmunity

Frontiers in Immunology, 2019
Karina Silina, David Kroeger
doaj   +1 more source

Orchestration of tertiary lymphoid structures: decoding developmental mechanisms for next-generation cancer immunotherapies

Medical Review
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates that form in non-lymphoid organs, frequently observed in conditions such as cancer, autoimmune diseases, transplant rejection, and chronic inflammation.
Hao Wenqin, Zhao Ying
doaj   +1 more source

B Cell Activating Factor (BAFF) Is Required for the Development of Intra-Renal Tertiary Lymphoid Organs in Experimental Kidney Transplantation in Rats. [PDF]

Int J Mol Sci, 2020
Steines L, Poth H, Herrmann M, Schuster A, Banas B, Bergler T.   +5 more
europepmc   +1 more source