Results 51 to 60 of about 9,564 (122)

Tertiary lymphoid structures and B lymphocytes: a promising therapeutic strategy to fight cancer

Frontiers in Immunology, 2023
Tertiary lymphoid structures (TLSs) are clusters of lymphoid cells with an organization that resembles that of secondary lymphoid organs. Both structures share common developmental characteristics, although TLSs usually appear in chronically inflamed non-
Laura Esparcia-Pinedo, Laura Esparcia-Pinedo, Nuria Romero-Laorden, Nuria Romero-Laorden, Arantzazu Alfranca, Arantzazu Alfranca, Arantzazu Alfranca, Arantzazu Alfranca   +7 more
doaj   +1 more source

Tertiary lymphoid structures in pulmonary granulomas of cattle experimentally infected with aerosolized Mycobacterium bovis

BMC Veterinary Research
Mycobacterium bovis is the primary cause of tuberculosis in animals, most notably cattle. In cattle and other susceptible hosts, the hallmark lesion of tuberculosis is the granuloma.
Mitchell V. Palmer, Douglas E. Jones, Nicholas J. Bockenstedt, Paola M. Boggiatto   +3 more
doaj   +1 more source

Stroma cell priming in enteric lymphoid organ morphogenesis

Frontiers in Immunology, 2012
The lymphoid system is equipped with a network of specialized platforms located at strategic sites, which grant strict immune-surveillance and efficient immune responses.
Manuela eFerreira, Rita Gomes Domingues, Henrique eVeiga-Fernandes   +2 more
doaj   +1 more source

Lymphoid aggregates that resemble tertiary lymphoid organs define a specific pathological subset in metal-on-metal hip replacements.

PLoS ONE, 2013
Aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL) has been used to describe the histological lesion associated with metal-on-metal (M-M) bearings.
Saloni Mittal, Matthew Revell, Francesca Barone, Debbie L Hardie, Gulraj S Matharu, Alison J Davenport, Richard A Martin, Melissa Grant, Frederick Mosselmans, Paul Pynsent, Vaiyapuri P Sumathi, Owen Addison, Peter A Revell, Christopher D Buckley   +13 more
doaj   +1 more source

Artery tertiary lymphoid organs in atherosclerosis: A review

Life Sciences
Atherosclerosis (AS) is the common pathological basis for many cardiovascular diseases. Initial investigations into AS predominantly centered on endothelial immune responses associated with plaque formation. However, recent studies increasingly underscore the salutary immune modulation occurring on the aorta adventitia as the atheromatous plaque ...
Yanni, Li, Sihe, Gong, Kaijie, Yan, Zhonghong, Shi, Yimin, Bao, Ke, Ning   +5 more
openaire   +2 more sources

Growth of Murine Splenic Tissue Is Suppressed by Lymphotoxin β-Receptor Signaling (LTβR) Originating from Splenic and Non-Splenic Tissues. [PDF]

PLoS ONE, 2016
Development and maintenance of secondary lymphoid organs such as lymph nodes and spleen essentially depend on lymphotoxin β-receptor (LTβR) signaling. It is unclear, however, by which molecular mechanism their size is limited.
Novica M Milićević, Klaus Nohroudi, Friederike Schmidt, Hendrik Schmidt, Cornelia Ringer, Grith Lykke Sorensen, Živana Milićević, Jürgen Westermann   +7 more
doaj   +1 more source

Adventitial inflammation and its interaction with intimal atherosclerotic lesions

Frontiers in Physiology, 2014
The presence of adventitial inflammation in correlation with atherosclerotic lesions has been recognized for decades. In the last years, several studies have investigated the relevance and impact of adventitial inflammation on atherogenesis.
Mohammadreza eAkhavanpoor, Susanne eWangler, Christian Albert Gleissner, Grigorios eKorosoglou, Hugo Albert Katus, Christian eErbel   +5 more
doaj   +1 more source

The role of dendritic cells in tertiary lymphoid structures: implications in cancer and autoimmune diseases

Frontiers in Immunology
Tertiary Lymphoid Structures (TLS) are organized aggregates of immune cells such as T cells, B cells, and Dendritic Cells (DCs), as well as fibroblasts, formed postnatally in response to signals from cytokines and chemokines.
Mariana Reste, Kristi Ajazi, Ayca Sayi-Yazgan, Ayca Sayi-Yazgan, Radmila Jankovic, Biljana Bufan, Sven Brandau, Espen S. Bækkevold, Florent Petitprez, Malin Lindstedt, Gosse J. Adema, Catarina R. Almeida   +11 more
doaj   +1 more source

Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?

Frontiers in Immunology, 2017
Secondary lymphoid organs are integral to initiation and execution of adaptive immune responses. These organs provide a setting for interactions between antigen-specific lymphocytes and antigen-presenting cells recruited from local infected or inflamed ...
Emily Jayne Colbeck, Ann Ager, Awen Gallimore, Gareth Wyn Jones   +3 more
doaj   +1 more source

The dual role of inflammation and tertiary lymphoid structures in tumor progression and immunity: a literature review and our experience [PDF]

Pharmacia
In the last decade, the term tertiary lymphoid structures (TLSs) has gained significant attention and is used to describe ectopic lymphoid organs that exhibit characteristics similar to secondary lymphoid organs (SLOs) and form in response to chronic ...
Milena Gulinac, Tsvetelina Velikova, Petra Kavradjieva, Vasko Grklanov, Kostadin Gigov, Ivan Ginev, Dorian Dikov   +6 more
doaj   +3 more sources