Results 111 to 120 of about 6,088 (246)

Mature tertiary lymphoid structure associated CD103+ CD8+ Trm cells determined improved anti-tumor immune in breast cancer

Frontiers in Oncology
Background Although tertiary lymphoid structures (TLS) play crucial roles in the anti-tumor immune response and are associated with favorable prognoses in many solid tumors, the precise mechanisms by which TLSs enhance anti-tumor immunity remain poorly ...
Qin Fang, Shuru Chen, Xiaoyue Chen, Wei Zou, Di Chen, Yukang Huang, Chucheng Wu   +6 more
semanticscholar   +1 more source

The Absence of Intra‐Tumoral Tertiary Lymphoid Structures is Associated with a Worse Prognosis and mTOR Signaling Activation in Hepatocellular Carcinoma with Liver Transplantation: A Multicenter Retrospective Study

Advanced Science
Tertiary lymphoid structure (TLS) can predict the prognosis and sensitivity of tumors to immune checkpoint inhibitors (ICIs) therapy, whether it can be noninvasively predicted by radiomics in hepatocellular carcinoma with liver transplantation (HCC‐LT ...
Jianhua Li, Li Zhang, Hao Xing, Yan Geng, Shaocheng Lv, Xiao Luo, Weiqiao He, Zhi Fu, Guangming Li, Bin Hu, Shengran Jiang, Zhe Yang, Ningqi Zhu, Quanbao Zhang, Jing Zhao, Yifeng Tao, Conghuan Shen, Ruidong Li, Feng Tang, Shusen Zheng, Yun Bao, Qiang He, Daoying Geng, Zhengxin Wang   +23 more
doaj   +1 more source

Autocrine/paracrine lysophosphatidylserine signaling suppresses B cell aggregation and tertiary lymphoid structure formation

iScience
Summary Accumulating evidence suggests that Gα13 signaling by G protein-coupled receptors negatively regulate B cell function. We report here that lysophosphatidylserine (LysoPS), an emerging immunoregulatory lysophospholipid, is produced upon B cell ...
Akiharu Uwamizu, Yuji Shinjo, Jumpei Omi, Manae Tatstumi, K. Kano, Kumiko Makide, Hajime Kitamura, Michiyo Okudaira, Keita Satoh, F. Fukami, T. Kawano, T. Miyasaka, Tomoko Takahashi, Osamu Nakajima, Tomohiko Ohwada, A. Inoue, Jun Aoki   +16 more
semanticscholar   +1 more source

Characterizing tertiary lymphoid structures associated single-cell atlas in breast cancer patients

Cancer Cell International
The tertiary lymphoid structure (TLS) is recognized as a potential prognosis factor for breast cancer and is strongly associated with response to immunotherapy.
Xiaokai Fan, Daqin Feng, Donggui Wei, Anqi Li, Fangyi Wei, Shufang Deng, Muling Shen, Congzhi Qin, Yongjia Yu, Lun Liang   +9 more
doaj   +1 more source

B cells and iBALT in TB immunity & pathogenesis

Frontiers in Immunology
B cells play a crucial role in immunity against various infectious diseases. However, their role in tuberculosis (TB) has been largely understudied. Emerging evidence suggests that B cells actively shape immune responses in TB.
Taru S. Dutt, Robert Krause, David Hertz, Marcela Henao-Tamayo, Alasdair Leslie, Alasdair Leslie, Bianca Schneider   +6 more
doaj   +1 more source

Tertiary lymphoid structures (TLS) identification and density assessment on H&E-stained digital slides of lung cancer [PDF]

, 2021
Tertiary lymphoid structures (TLS) are ectopic aggregates of lymphoid cells in inflamed, infected, or tumoral tissues that are easily recognized on an H&E histology slide as discrete entities, distinct from lymphocytes.
Alexander, DC, Barmpoutis, P, Di Capite, M, Jansen, M, Kayhanian, H, Kwong, FNK, Waddingham, W   +6 more
core  

Retrospective study on the correlation between CXCL13, immune infiltration, and tertiary lymphoid structures in cutaneous squamous cell carcinoma [PDF]

PeerJ
Background C-X-C motif chemokine ligand 13 (CXCL13) is a crucial chemokine for the recruitment of immune cells and the formation of tertiary lymphoid structure (TLS) in the tumor microenvironment.
Yulu Chen, Yuhao Wu, Zijun Zhao, Long Wen, Mingshun Wu, Dekun Song, Qingyu Zeng, Yeqiang Liu, Guorong Yan, Guolong Zhang   +9 more
doaj   +2 more sources

Tertiary lymphoid structures: Defining immune subtypes and enabling precision immunotherapy in nasopharyngeal carcinoma

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
Fan Liu, Lei Xiong, Xia Yu, Mingfang Ji
wiley   +1 more source

Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections

Advanced Science
Tertiary lymphoid structure (TLS) is associated with various pathologies, including those of cancers and chronic infections. Depending on the organ, multiple factors regulate the formation of TLS.
Ruiqi Li, Fan Gu, Linlin Peng, Tingting Huan, Zhuo Zhou, Yaling Song, Jinmei He, Kaili Ye, Yao Sun, Tiejun Li, Miao He, Zhuan Bian, Wei Yin   +12 more
doaj   +1 more source

Tertiary lymphoid structures predict survival and response to neoadjuvant therapy in locally advanced rectal cancer

npj Precision Oncology
Tertiary lymphoid structure (TLS) contributes to the anti-tumor immune response, and predicts the prognosis of colorectal cancer patients. However, the potential impact of TLS in shaping the immune status of rectal adenocarcinoma, and the intrinsic ...
Qianyu Wang, Wentao Zhong, Xiaofei Shen, Zechen Hao, Meng Wan, Xiaopeng Yang, Ran An, Hongyan Zhu, Huiyun Cai, Tao Li, Yuan Lv, Xing Dong, Gang Chen, Aijun Liu, Junfeng Du   +14 more
doaj   +1 more source