Results 131 to 140 of about 6,088 (246)

Dynamics of tertiary lymphoid structures and immune cross talk in early versus advanced colorectal cancer: potential implications for immunotherapy

Cancer Immunology, Immunotherapy
Background Irrespective of microsatellite status, immune checkpoint inhibitor therapy shows superior efficacy in early-stage colorectal cancer (CRC) compared to advanced cases.
Zixu Chen, Bang Hu, Keyu Cai, Han Gao, Zhenyu Xian, Shuang Zhang, Zhen Fang, Qian Zhou, Donglin Ren, Qi Zou   +9 more
doaj   +1 more source

Analyses of germinal center B cells and tertiary lymphoid structures (TLS) in mouse and human HNSCC

Laryngo-Rhino-Otologie, 2019
M Sonntag, C Brunner, TK Hoffmann
openaire   +1 more source

606 IMpower110: Tertiary lymphoid structures (TLS) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) treated with first-line atezolizumab or chemotherapy

Regular and Young Investigator Award Abstracts, 2023
Robert Johnston, Hartmut Koeppen, Roy S Herbst, Kurt Schalper, Filippo De Marinis, Giuseppe Giaccone, Jacek Jassem, Marcus Ballinger, Barani Kumar Rajendran, David R Spigel, Miguel López de Rodas, Minu K Srivastava, Jennifer M Giltnane, Barzin Y Nabet, David S Shames, Velimir Gayevskiy, Vy Ma, Ivette Estay, Tien Hoang, Reena Amin   +19 more
openaire   +2 more sources

Tertiary lymphoid structures combined with biomarkers of inflammation are associated with the efficacy of neoadjuvant immunochemotherapy in resectable non‐small cell lung cancer: A retrospective study

Thoracic Cancer
Background Neoadjuvant immunochemotherapy can effectively downstage tumors and reduce the risk of postoperative recurrence and distant metastasis in patients with non‐small cell lung cancer (NSCLC).
Fuhao Xu, He Zhu, Dali Xiong, Kang Wang, Yinjun Dong, Li Li, Shuanghu Yuan   +6 more
doaj   +1 more source

Artificial Intelligence (AI)-Powered H&E Whole-Slide Image Analysis of Tertiary Lymphoid Structure (TLS) Independently Predicts Survival in Patients with Non-Small Cell Lung Cancer (NSCLC) Receiving Immunotherapy

ABSTRACT Background Tertiary lymphoid structures (TLSs) within the tumor microenvironment have emerged as potential indicators of treatment response to immune checkpoint inhibitors (ICIs). This study aims to explore the association between artificial intelligence (AI)-powered TLS analysis and treatment ...
Leeseul Kim, Sangwon Shin, Behtash G Nezami, Borislav Alexiev, Soo Ick Cho, Sanghoon Song, Wonkyung Jung, Lee AD Cooper, Donghoon Shin, Junho Song, Taekyu Um, Liam Il-Young Chung, Young Kwang Chae   +12 more
openaire   +1 more source

BALTing the lung immune response [PDF]

Tertiary Lymphoid Structures (TLS) are aggregates of immune cells in non-lymphoid tissue. Located in several organs, they drive immune responses against infections, cancer, and autoimmune diseases.
Kirkby, Margarida Ferreira Pereira Bobela
core  

Spatial relationships and interactions of immune cell niches are linked to the pathologic response of muscle-invasive bladder cancer to neoadjuvant therapy

Journal of Translational Medicine
Background The identification of the complex spatial architecture of immune cell infiltration and its interaction mechanisms within tumor ecosystems provides crucial insights into therapeutic responses to neoadjuvant therapy in muscle-invasive bladder ...
Wasilijiang Wahafu, Quan Zhou, Xihua Yang, Yongming Yang, Yuanyuan Zhao, Zhu Wang, Xiangpeng Kang, Xiongjun Ye, Nianzeng Xing   +8 more
doaj   +1 more source

Editorial: Tertiary lymphoid structures (TLS) in the tumor immune microenvironment

Frontiers in Immunology
Xinbo Gao, Xiangqin Zhao, Xuesong Li, Jin Zhang, Hui Zhao, Ying Ma   +5 more
openaire   +3 more sources

IMpower110: tertiary lymphoid structures (TLS) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) treated with first line atezolizumab ro chemotherapy

Journal for ImmunoTherapy of Cancer, 2023
Srivastava, Minu, Gayevskiy, Velimir, Ma, Vy, Estay, Ivette, de Rodas, Miguel, Rajendram, Barani, Hoang, Tien, Ballinger, Marcus, Amin, Reena, Herbst, Roy, de Marinis, Filippo, Giaccone, Giuseppe, Spigel, David, Schalper, Kurt, Koeppen, Hartmut, Shames, David, Johnston, Robert, Giltnane, Jennifer, Nabet, Barzin   +18 more
openaire   +1 more source

Tertiary lymphoid structures are associated with lower axillary residual nodal burden in breast cancer patients after neoadjuvant chemotherapy. [PDF]

Eur J Med Res
Wei Z, Lin K, Deng W, Chen Y, Lu Y.
europepmc   +1 more source