Results 181 to 190 of about 6,088 (246)

Abstract 2211: The prognostic role of tertiary lymphoid structure (TLS) in locally advanced esophageal squamous cell carcinoma (ESCC)

Cancer Research, 2023
Introduction: The presence of TLS in tumors is associated with improved efficacy of immunotherapy in various types of cancer. The significance of TLS in patients with ESCC has been sporadically reported.
Ta-Chen Huang, C. Liang, Yu-I Li, Jhe-Cyuan Guo, Chia‐Chi Lin, Jang-Ming Lee, Y. Chao, Chih-Hung Hsu   +7 more
semanticscholar   +2 more sources

Abstract 5627: Functional tertiary lymphoid structure (TLS) and outcome in HER2-positive (HER2+) breast cancer in NCCTG N9831 (Alliance)

Cancer Research, 2022
Background: Previous studies showed conflicting results regarding association between stromal tumor infiltrating lymphocytes (sTIL) and outcome in HER2+ breast cancer.
S. Chumsri, Tracy R. Shachner, Zhuo Li, N. Norton, A. Moreno-Aspitia, G. Colón-Otero, E. Perez, E. Thompson, A. Nassar, K. Knutson   +9 more
semanticscholar   +2 more sources

Artificial intelligence (AI) –powered H&E whole-slide image (WSI) analysis of tertiary lymphoid structure (TLS) correlates with immune phenotype and related molecular signatures in non–small-cell lung cancer.

Journal of Clinical Oncology, 2023
e20520 Background: Recent data suggested immune infiltrates in TLS around tumor bed may be a favorable predictive factor for immunotherapy in various cancers.
Sanghoon Song, W. Jung, S. Cho, Juneyoung Ro, Hajin Lee, M. Ma, Seonwook Park, D. Yoo, L. Kim, L. Chung, Y. Chae, C. Ock   +11 more
semanticscholar   +2 more sources

Abstract 4909: An RNA-based model for tertiary lymphoid structure (TLS) prediction and classification in pancreatic adenocarcinoma (PDAC)

Cancer Research
Although TLS status possesses prognostic significance in PDAC and can potentially affect chemotherapy outcomes, there is currently a notable lack of RNA sequencing (RNA-seq) models that specialize in TLS identification and classification in PDAC. Here,
Alexandra Livanova, Andrey Tyshevich, Andrey Kravets, Stanislav Kurpe, Nadezhda Lukashevich, Dmitry Ivchenkov, Daniil Dymov, Anna Belozerova, K. Kryukov, A. Sarachakov, V. Svekolkin, V. Kushnarev   +11 more
semanticscholar   +2 more sources

Artificial intelligence (AI) -powered H&E whole-slide image (WSI) analysis of tertiary lymphoid structure (TLS) to predict response to immunotherapy in non-small cell lung cancer (NSCLC).

Journal of Clinical Oncology
3135 Background: Recent data indicate that immune cells present in the TLS within the tumor microenvironment (TME) could potentially serve as a favorable predictor for immune checkpoint inhibitor (ICI) therapy.
L. Kim, Sangwon Shin, S. Cho, W. Jung, Sanghoon Song, L. Chung, C. Ock, Y. Chae   +7 more
semanticscholar   +2 more sources

Abstract 6826: Comparative analysis of a predictive transcriptomic model and functional gene expression signatures (FGES) for tertiary lymphoid structure (TLS) detection in lung adenocarcinoma (LUAD)

Cancer Research
Background: TLS are recognized as significant biomarkers for patient prognosis and therapy selection. In current clinical practice, TLS are often detected by manual assessment of H&E slides, which has been associated with reproducibility issues.
Nadezhda Lukashevich, Daniil Dymov, A. Sarachakov, Sofya Kust, A. Love, I. Valiev, Dmitry Ivchenkov, A. Bagaev, V. Svekolkin, N. Kotlov, V. Kushnarev   +10 more
semanticscholar   +2 more sources

A digital imaging analysis (DIA) platform for identifying tertiary lymphoid structures (TLS) in lung adenocarcinoma (LUAD).

Journal of Clinical Oncology, 2022
3142 Background: Previous studies of non-small cell lung cancer (NSCLC) have shown that TLS can be predictive of therapy response and a positive prognostic factor for survival. Currently, TLS identification is manually performed by pathologists with limited morphological criteria. Standardizing TLS detection with an automated DIA workflow could guide
Vladimir Kushnarev, Anna Belozerova, Daniil Dymov, Yuriy Popov, Nadezhda Lukashevich, Ivan Valiev, Diana Shamsutdinova, Aida Akaeva, Ilia Galkin, Lev Popyvanov, Viktor Svekolkin, Krystle Nomie, Anna Love, Alexander Bagaev, Ekaterina Postovalova, Nathan Fowler   +15 more
openaire   +1 more source

Abstract 4655: The prognostic significance of a 12-chemokine tertiary lymphoid structure (TLS) gene signature in uveal melanoma (UM)

Cancer Research, 2023
Abstract Introduction Lymphoid aggregates are commonly associated with better prognosis and enhanced response to immune modulators in several cancers. Considering the immune-privileged status of the eye we sought to investigate the immune, genomic and prognostic significance of 12-chemokine TLS gene signature in UM patients.
Hassan Mohammed Abushukair, Ayah Al-Bzour, Andrew Knight, Walter J. Storkus, John M. Kirkwood, Lilit Karapetyan   +5 more
openaire   +1 more source

Abstract 1705: Spatial interrogation of tertiary lymphoid structures (TLS) in colorectal carcinoma (CRC) tumor microenvironment (TME) using the MultiOmyx࣪ assay

Cancer Research, 2022
Abstract Immune checkpoint blockade (ICB) therapy has revolutionized the landscape of cancer therapy in multiple tumor types since Ipilimumab, the first ICB agent, was approved for the treatment of metastatic melanoma is 2011. Current predictive biomarkers for therapy response include PD-L1 expression, tumor mutational burden (TMB) and ...
Harry Nunns, Erinn A. Parnell, Michael Lazare, Judy Kuo, Eric Leones, Flora Sahafi, Josette William, Qingyan Au   +7 more
openaire   +1 more source

Abstract 74: Engineering tertiary lymphoid structures for glioblastoma: A novel gene combination promotes therapeutic TLS formation in an immune-competent mouse model of GBM

Cancer Research, 2021
Abstract The absence of conventional lymphatic access to the brain parenchyma restricts the capacity of the peripheral immune system to recognize and elicit durable responses against glioma antigens. In some peripheral solid tumor types and autoimmune diseases such as multiple sclerosis, the spontaneous development of tertiary lymphoid ...
Kira Morgan Downey, Bindu Hegde, Zinal Chheda, Jason Zhang, Hideho Okada   +4 more
openaire   +1 more source