Results 211 to 220 of about 6,088 (246)

Predictive power of tertiary lymphoid structure for prognosis and neoadjuvant chemotherapy response in HER2-positive breast cancer

Medicine
This study evaluated the prognostic significance of tertiary lymphoid structures (TLS) in human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC), focusing on their associations with survival outcomes, response to neoadjuvant therapy,
Mengxi Li, Jing Cao, Yueheng Wang, Ziru Zhao, Liqiang Ai, Kejing Zhang   +5 more
semanticscholar   +1 more source

SO016/#846  Deep learning for spatial distribution of tertiary lymphoid structures (TLS) and efficacy of immunotherapy for endometrial cancer

Closing Session: the Development of Prognosis and Predictive Markers, 2023
Junzo Hamanishi, Haruka Suzuki, Akihiko Ueda, Ken Yamaguchi, Masaki Mandai   +4 more
openaire   +1 more source

Impact of tertiary lymphoid structure-associated biomarkers on pancreatic cancer via a dual-disease analysis of psoriasis and pancreatic cancer

Discover Oncology
Pancreatic cancer (PC), often referred to as the “king of cancers”, has demonstrated limited success with immunotherapies, many of which are still under development.
Hao Yu, Quan Yuan, Liu-Xing Feng, Jiahuan Xu, Shen-Yuan Zhan, Zhi-Min Li, Shuangjia Wang   +6 more
semanticscholar   +1 more source

Characterization of tertiary lymphoid structure identifies competitive binding of CD40 and STING with TRAF2 driving IRF4-mediated B cell activation in esophageal squamous cell carcinoma

Cancer Gene Therapy
Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with a dismal prognosis. Hitherto, little has been known regarding the clinical implications of tertiary lymphoid structures (TLS) and its biological mechanisms of antitumor ...
Yujia Zheng, Donglai Chen, Yi Xu, Xuejun Xu, Peidong Song, Xuejie Wu, Lijie Tan, Yiming Mao, Yongbing Chen   +8 more
semanticscholar   +1 more source

Abstract LB230: Generation of a B7-H4-restricted LTBR agonist to induce tertiary lymphoid structure formation in solid tumors

Cancer Research
Tertiary lymphoid structures (TLS) are lymph node-like structures that form in response to inflammation and facilitate immune activation within the local microenvironment. TLS prevalence in solid tumors has been associated with more favorable prognosis
Jiawei Huang, Jacqueline Tabor, Betty Li, S. Ramakrishnan, Helen Liu, Kikuye Koyano, Bin Fan, A. Kutach, Rujin Cheng, Ali Khateb, Jonathan B. Johnston, Noha Elabed, Leanne Wong, Roshni Nambiar, Matthias J. Scherr, Mark Humphrey, Jonathan Aguayo, Yadong Yu, Peng Wang, Alison Lucero, Peirong Chen, Kyle Tsukamoto, Meredith M. O'Conner, Andrew Goodyear, Curtis Lai, Leore T. Geller, Lisa K Blum, Shuin Park, Nicole Malandro, Rick Feldman, Ursula Jeffry, Daniel D Kaplan, Alessandro Palumbo, Jer-Yuan Hsu, Zimple Matharu, Lee B   +35 more
semanticscholar   +1 more source

5P Tertiary lymphoid structures (TLS) presence and stromal blood vessels heterogeneity differentially influence recurrence, lymphovascular, and perineural invasion in breast cancer molecular subtypes

Annals of Oncology, 2023
A.A. Cosma, A.C. Barb, S.M. Negru, M.M. Pasca Fenesan, A.M. Cimpean   +4 more
openaire   +1 more source

B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome

Nature Reviews Clinical Oncology, 2022
Wolf H Fridman, Maxime Meylan, Florent Petitprez   +2 more
exaly  

Nickel-catalyzed formation of quaternary carbon centers using tertiary alkyl electrophiles

Chemical Society Reviews, 2021
Weichao Xue, Xiao Jia, Xuan Wang
exaly  

Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort

Nature Medicine, 2022
Antoine Italiano, Emmanuelle Bompas, Catherine Sautes-fridman   +2 more
exaly  

Tertiary lymphoid structures in cancer

Science, 2022
Ton N M Schumacher, Daniela S Thommen
exaly