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Tertiary lymphoid structures in thyroid cancer [PDF]

Archives of Endocrinology and Metabolism
Objective: This study aimed to investigate the presence of tertiary lymphoid structures (TLSs) and tumor-infiltrating B cells within the germinal centers of TLSs in the tumor microenvironment of thyroid cancer, utilizing a morphological approach ...
Katia Sakimi Nakadaira, Kelly Cristina Saito, Cesar Seigi Fuziwara, Patricia Künzle Ribeiro Magalhães, Leandra Naira Zambelli Ramalho, Julio C. Ricarte-Filho, Lea Maria Zanini Maciel, Edna Teruko Kimura   +7 more
doaj   +3 more sources

Orchestration of tertiary lymphoid structures: decoding developmental mechanisms for next-generation cancer immunotherapies [PDF]

Medical Review
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates that form in non-lymphoid organs, frequently observed in conditions such as cancer, autoimmune diseases, transplant rejection, and chronic inflammation.
Hao Wenqin, Zhao Ying
doaj   +2 more sources

Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease? [PDF]

Frontiers in Immunology, 2017
Secondary lymphoid organs are integral to initiation and execution of adaptive immune responses. These organs provide a setting for interactions between antigen-specific lymphocytes and antigen-presenting cells recruited from local infected or inflamed ...
Emily Jayne Colbeck, Ann Ager, Awen Gallimore, Gareth Wyn Jones   +3 more
doaj   +7 more sources

Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures. [PDF]

, 2016
Lymphangiogenesis associated with tertiary lymphoid structure (TLS) has been reported in numerous studies. However, the kinetics and dynamic changes occurring to the lymphatic vascular network during TLS development have not been studied.
Barone, F., Buckley, C.D., Caamaño, J.H., Campos, J., Chachlani, M., Chung, M.M., Cloake, T., Gardner, D.H., Luther, S., McGettrick, H.M., Navarro-Núñez, L., Nayar, S., Rankin, P., Steinthal, N., Watson, S.P.   +14 more
core   +4 more sources

Identification and characterization of tertiary lymphoid structures in brain metastases. [PDF]

Acta Neuropathol Commun
Mughal SS, Reiss Y, Felsberg J, Meyer L, Macas J, Schlue S, Starzetz T, Köhrer K, Fehm T, Müller V, Lamszus K, Schadendorf D, Helfrich I, Wikman H, Berghoff A, Brors B, Plate KH, Reifenberger G.   +17 more
europepmc   +2 more sources

Tertiary lymphoid structures: The touchstone for tumor immunotherapy [PDF]

Acta Pharmaceutica Sinica B
Lisha Zhou, Shunji Liu, Yang Sun
doaj   +2 more sources

Tertiary lymphoid structures in cancer: spatiotemporal heterogeneity, immune orchestration, and translational opportunities​​. [PDF]

J Hematol Oncol
Deng S, Chen Y, Song B, Wang H, Huang S, Wu K, Chu Q.   +6 more
europepmc   +3 more sources

Newly formated (tertiary) lymphoid structures in tumor growth [PDF]

Наука и инновации в медицине, 2022
Aim to reproduce tertiary lymphoid structures and study their features in a malignant neoplasm in the experiment. Material and methods. Male white rats of the Wistar stress-resistant line were inoculated with the tumor strain sarcoma M1.
Rasul A. Rustamkhanov, Shamil R. Kzyrgalin, Dauranbek T. Arybzhanov, Kamil Sh. Gantsev, Davlat S. Tursumetov, Shamil Kh. Gantsev   +5 more
doaj   +1 more source

Tertiary Lymphoid Structures and Cancer Prognosis (Brief Review)

Креативная хирургия и онкология, 2020
This brief review is devoted to the role of tertiary lymphoid structures in oncological processes. A number of research studies carried out over the past ten years have shed light on the functions of such structures in various diseases, as well as their ...
R. A. Rustamkhanov, K. Sh. Gantsev, D. S. Tursumetov   +2 more
doaj   +1 more source

Does TLS Exist in Canine Mammary Gland Tumours? Preliminary Results in Simple Carcinomas

Veterinary Sciences, 2022
Neoplastic progression is influenced by the expression of tumour antigens that activate an anti-tumour immune response. Human medical studies show that this body defence is carried out in secondary lymphoid organs (SLOs) but also directly in the tumour ...
Giada Giambrone, Stefania Di Giorgio, Cecilia Vullo, Gabriele Marino, Roberto Puleio, Francesca Mariotti, Giuseppe Mazzullo, Alessandra Sfacteria   +7 more
doaj   +1 more source