Results 11 to 20 of about 29,370 (346)
Heterogeneity of tertiary lymphoid structures in cancer
Frontiers in Immunology, 2023 The success of immunotherapy approaches, such as immune checkpoint blockade and cellular immunotherapy with genetically modified lymphocytes, has firmly embedded the immune system in the roadmap for combating cancer. Unfortunately, the majority of cancer
Xin You +5 more
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Tertiary Lymphoid Structures: Autoimmunity Goes Local [PDF]
Frontiers in Immunology, 2018 Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune diseases. TLS present features of secondary lymphoid organs such as segregated T and B cell zones, presence of follicular dendritic cell networks, high endothelial ...
Elena Pipi +6 more
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Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer
Frontiers in Immunology, 2023 Tertiary lymphoid structures (TLS) are lymph node-like aggregates that can form in association with chronic inflammation or cancer. Mature TLS are organized into B and T cell zones, and are not encapsulated but include all cell types necessary for ...
Alessandra Vaccaro +4 more
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Tertiary lymphoid structures in colorectal cancer
Annals of MedicineBackground Tertiary lymphoid structures (TLS) are ectopic clusters of immune cells found in non-lymphoid tissues, particularly within the tumor microenvironment (TME).
Jianyu Lv +5 more
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Tertiary lymphoid structures in autoimmune diseases
Frontiers in ImmunologyTertiary lymphoid structures (TLSs) are organized lymphoid-like aggregations in non-lymphoid tissues. Tissues with chronic and persistent inflammation infiltration may drive and form ectopic germinal center-like structures, which are very common in ...
Yuanji Dong, Ting Wang, Huaxiang Wu
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Tertiary lymphoid structures: new immunotherapy biomarker
Frontiers in ImmunologyImmunotherapy shows substantial advancement in cancer and is becoming widely used in clinical practice. A variety of biomarkers have been proposed to predict the efficacy of immunotherapy, but most of them have low predictive ability.
Fangyuan Yang +5 more
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Tertiary lymphoid structures in ovarian cancer
Frontiers in ImmunologyOvarian cancer (OC) is a significant cause of cancer-related mortality in women worldwide. Despite advances in treatment modalities, including surgery and chemotherapy, the overall prognosis for OC patients remains poor, particularly for patients with ...
Guojuan Sun, Yi Liu
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Tertiary lymphoid structures in cancer: maturation and induction
Frontiers in ImmunologyTertiary lymphoid structure (TLS) is an ectopic lymphocyte aggregate formed in peripheral non-lymphoid tissues, including inflamed or cancerous tissue.
Yulu Chen +11 more
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Tertiary lymphoid structures and gastric cancer prognosis
APMIS, 2022 Tertiary lymphoid structures (TLSs) are part of immune response against cancer. Their high density and high diameter have been shown to be associated with prognosis in different cancer types. The aim of this study was to examine the prognostic significance of TLS density and diameter in gastric cancer and reproducibility of their assessments.
Kemi, N. (Niko) +7 more
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IJU Case Reports, 2023 Introduction Although undifferentiated pleomorphic sarcomas are aggressive, a subset of these tumors are immunogenic and may respond to immunotherapy.
Hidetoshi Kokubun +9 more
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