Lymphoid aggregates in desmoplastic melanoma have features of tertiary lymphoid structures [PDF]
Melanoma Research, 2018 Desmoplastic melanomas (DM) have unique and challenging clinical presentations and histomorphology. A characteristic feature is the presence of scattered lymphoid aggregates. However, the nature of these aggregates is not defined. We hypothesized that they may be tertiary lymphoid structures (TLS), and may be associated with programmed death ligand 1 ...
Anne M, Stowman +5 more
openaire +2 more sources
Subacute Sclerosing Panencephalitis of the Brainstem as a Clinical Entity. [PDF]
, 2017 Subacute sclerosing panencephalitis (SSPE) is a rare progressive neurological disorder of early adolescence caused by persistent infection of the measles virus, which remains prevalent worldwide despite an effective vaccine. SSPE is a devastating disease
Ciacci, Joseph D +3 more
core +3 more sources
Early IL-1 signaling promotes iBALT induction after influenza virus infection [PDF]
, 2016 Inducible bronchus-associated lymphoid tissue (iBALT) is a long lasting tertiary lymphoid tissue that can be induced following influenza A virus (IAV) infection.
Deswarte, K. (Kim) +4 more
core +5 more sources
Cancer Immunotherapies: From Efficacy to Resistance Mechanisms – Not Only Checkpoint Matters
Frontiers in Immunology, 2021 The immunotherapeutic treatment of various cancers with an increasing number of immune checkpoint inhibitors (ICIs) has profoundly improved the clinical management of advanced diseases.
Shuyue Wang, Kun Xie, Tengfei Liu
doaj +1 more source
Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer [PDF]
, 2016 Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally, in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling pro-tumor chronic inflammation.
BARNABA, Vincenzo +14 more
core +1 more source
Tertiary Lymphoid Structures as Mediators of Immunotherapy Response
Cancers, 2022 Since its first application in the treatment of cancer during the 1800s, immunotherapy has more recently become the leading edge of novel treatment strategies. Even though the efficacy of these agents can at times be predicted by more traditional metrics and biomarkers, often patient responses are variable.
Raj G. Vaghjiani, Joseph J. Skitzki
openaire +2 more sources
Artery tertiary lymphoid organs control multi-layered territorialized atherosclerosis B cell responses in aged ApoE-/- mice [PDF]
, 2016 Objective: Explore aorta B cell immunity in aged ApoE-/- mice. Approach and Results: Transcript maps, FACS, immunofluorescence analyses, cell transfers, and Ig-ELISPOT assays showed multi-layered atherosclerosis B cell responses in artery tertiary ...
Andreas J.R. Habenicht +13 more
core +1 more source
OncoImmunology, 2022 Pancreatic ductal adenocarcinoma (PDA) is usually unresponsive to immunotherapeutic approaches. However, tertiary lymphoid structures (TLS) are associated with favorable patient outcomes in PDA.
Azaz Ahmed +8 more
doaj +1 more source
CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren’s syndrome patients and correlates with focus score and disease activity [PDF]
, 2017 Background: Primary Sjögren’s syndrome (pSS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and peripheral lymphocyte perturbation.
A Bhattacharya +58 more
core +3 more sources
Long-lasting cross-protection against influenza A by neuraminidase and M2e-based immunization strategies [PDF]
, 2016 There is mounting evidence that in the absence of neutralizing antibodies cross-reactive T cells provide protection against pandemic influenza viruses. Here, we compared protection and CD8+ T cell responses following challenge with H1N1 2009 pandemic and
Callewaert, Nico +9 more
core +2 more sources