Results 161 to 170 of about 4,769 (183)
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Cancer Research
Abstract The presence of tertiary lymphoid structures (TLSs) and associated high endothelial venules (HEVs) in tumors is recognized as a hallmark of effective antitumor immunity. Improved prognosis and treatment outcomes across tumor stages and modalities (including immune checkpoint blockade, VEGF/PD1, chemotherapy and radiotherapy ...
Marta Lewandowska +7 more
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Abstract The presence of tertiary lymphoid structures (TLSs) and associated high endothelial venules (HEVs) in tumors is recognized as a hallmark of effective antitumor immunity. Improved prognosis and treatment outcomes across tumor stages and modalities (including immune checkpoint blockade, VEGF/PD1, chemotherapy and radiotherapy ...
Marta Lewandowska +7 more
openaire +1 more source
Clinical Cancer Research
Abstract Background: Tertiary lymphoid structures (TLS), which are organized ectopic lymphoid aggregates resembling secondary lymphoid organs, have been associated with improved outcomes across various cancer types.
S. Chumsri +13 more
openaire +1 more source
Abstract Background: Tertiary lymphoid structures (TLS), which are organized ectopic lymphoid aggregates resembling secondary lymphoid organs, have been associated with improved outcomes across various cancer types.
S. Chumsri +13 more
openaire +1 more source
Cancer Research
Abstract Significant clinical evidence demonstrates an association of tertiary lymphoid structure (TLS) formation with cancer survival. Clinically translatable pharmacologic/biologic agents that induce TLS-rich tumor immune environment could provide a breakthrough strategy to treat therapy-resistant cancers.
Yasuhiro Kikuchi +3 more
openaire +1 more source
Abstract Significant clinical evidence demonstrates an association of tertiary lymphoid structure (TLS) formation with cancer survival. Clinically translatable pharmacologic/biologic agents that induce TLS-rich tumor immune environment could provide a breakthrough strategy to treat therapy-resistant cancers.
Yasuhiro Kikuchi +3 more
openaire +1 more source
Journal of Clinical Oncology
3135 Background: Recent data indicate that immune cells present in the TLS within the tumor microenvironment (TME) could potentially serve as a favorable predictor for immune checkpoint inhibitor (ICI) therapy. To examine this further, AI model was created to provide an assessment of TLS in H&E WSI, and to determine its correlation with survival ...
Leeseul Kim +7 more
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3135 Background: Recent data indicate that immune cells present in the TLS within the tumor microenvironment (TME) could potentially serve as a favorable predictor for immune checkpoint inhibitor (ICI) therapy. To examine this further, AI model was created to provide an assessment of TLS in H&E WSI, and to determine its correlation with survival ...
Leeseul Kim +7 more
openaire +1 more source
Cancer Research
Abstract Background: Tertiary lymphoid structure (TLS) is an organized form of ectopic lymphoid aggregates (LA) with secondary lymphoid organ structure. Several studies showed that the presence of TLS associates with improved outcomes in multiple cancers when treated with immune checkpoint inhibitors.
Saranya Chumsri +9 more
openaire +1 more source
Abstract Background: Tertiary lymphoid structure (TLS) is an organized form of ectopic lymphoid aggregates (LA) with secondary lymphoid organ structure. Several studies showed that the presence of TLS associates with improved outcomes in multiple cancers when treated with immune checkpoint inhibitors.
Saranya Chumsri +9 more
openaire +1 more source