Synthesis of a GGTase Substrate for Possible Oncogenesis Identification and Inhibition [PDF]
, 2021 Geranylgeranyl transferase (GGTase) is an enzyme involved in the prenylation of many proteins, including Ras proteins. Prenylation is the addition of a hydrophobic hydrocarbon chain to a molecule.
Dammar, Haley
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Bioorthogonal Chemistry for Pretargeted PET Imaging [PDF]
, 2014 Positron Emission Tomography (PET) is emerging as a powerful method for imaging cancer through the design and development of new radiotracers. Antibodies have promising properties as ligands for targeting cancer, as they have the advantage of displaying ...
Evans, Helen
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ChemBioChem, 2018 AbstractBioorthogonal chemistry can be used for the selective modification of biomolecules without interfering with any other functionality that might be present. Recent developments in the field include orthogonal bioorthogonal reactions to modify multiple biomolecules simultaneously.
Eising, S. +6 more
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Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET [PDF]
, 2017 Protein kinases share significant structural similarity; however, structural features alone are insufficient to explain their diverse functions. Thus, bridging the gap between static structure and function requires a more detailed understanding of ...
Alexandrov, Y +10 more
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Click Chemistry in Materials Science [PDF]
, 2014 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106803/1/adfm201302847 ...
Bowman, Christopher N. +3 more
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Chemistry – An Asian JournalAbstractSmall molecule‐responsive tags for targeted protein degradation are valuable tools for fundamental research and drug target validation. Here, we show that genetically incorporated unnatural amino acids bearing a strained alkene or alkyne functionality can act as a minimalist tag for targeted protein degradation.
Jinghao Chen +6 more
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Radiolabelling of peptides with tetrazine ligation based on the inverse electron-demand Diels-Alder reaction: rapid, catalyst-free and mild conversion of 1,4-dihydropyridazines to pyridazines. [PDF]
RSC Adv, 2023 Otaru S +6 more
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Development Of Reactions And Methods For Labeling Biomolecules In Cells [PDF]
, 2016 The complexity of cellular environments presents a challenge to efforts at studying and elucidating biomolecules in cells. Covalent ligation of biomolecules with fluorescent molecules that have a reactive functional group that can react with a ...
Adogla, Enoch Agbesi
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Tetrazine–trans-cyclooctene ligation: Unveiling the chemistry and applications within the human body
Bioorganic ChemistryBioorthogonal reactions have revolutionized chemical biology by enabling selective chemical transformations within living organisms and cells. This review comprehensively explores bioorthogonal chemistry, emphasizing inverse-electron-demand Diels-Alder (IEDDA) reactions between tetrazines and strained dienophiles and their crucial role in chemical ...
Tomarchio, Elisabetta Grazia +6 more
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68Ga-Labeled radiopharmaceuticals for pretargeted PET imaging : synthesis of 68Ga-HBED-CC-tetrazines [PDF]
, 2017 An extremely high demand of 68Ga-radiotracers has ascended during the last decade in the field of nuclear medicine. 68Ga is a positron emitting radionuclide which is widely used in positron emission tomography (PET) studies due to its short half-live of ...
Honkaniemi, Elina
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