Results 81 to 90 of about 2,522 (183)

Vinylboronic acid-caged prodrug activation using click-to-release tetrazine ligation

Organic & Biomolecular Chemistry, 2019
Vinylboronic acids react selectively with tetrazines containing a boron-coordinating substituent. The authors explore this coordination-assisted cycloaddition for the click-to-release activation of a therapeutic drug.
Lianne P. W. M. Lelieveldt, Selma Eising, Abel Wijen, Kimberly M. Bonger   +3 more
openaire   +5 more sources

Diverse reactivity of maleimides in polymer science and beyond

Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.
This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick, Kristi S Anseth, Tayler S Hebner   +2 more
wiley   +1 more source

A Noncovalent Click‐to‐Release Strategy to Control Bond Cleavage and Prodrug Activation

Angewandte Chemie, Volume 138, Issue 9, 23 February 2026.
Extending the click‐to‐release concept beyond covalent ligation, we introduce a noncovalent click‐to‐release strategy based on cucurbituril‐adamantane (CB‐Ad) association. A supramolecular preassembly encapsulating a self‐immolative guest (SIG) is rationally designed to prevent premature release, while adding a high‐affinity Ad guest initiates the CB ...
Xuancheng Fu, Bowen Xu, Suman Maity, Michelle Wu, Luke G. Westbrook, James H. Henderson, Yaoying Wu, Katie A. Edwards, Atanu Acharya, Xiaoran Hu   +9 more
wiley   +2 more sources

In situ construction of intracellular supramolecular assemblies as an alternative strategy for protein degradation

Nature Communications
Targeted protein degradation has emerged as a promising anticancer strategy. Bringing disease-related proteins into proximity with the degradation system is crucial but often hindered by the availability of suitable ligands for proteins of interest (POIs)
Xiaoqian Hu, Qingxin Yao, Xiaobo Wu, Jiali Chen, Ruijia Zhang, Yan Zhao, Yuan Gao   +6 more
doaj   +1 more source

Development of a 99mTc-labeled tetrazine for pretargeted SPECT imaging using an alendronic acid-based bone targeting model.

PLoS ONE
Pretargeting, which is the separation of target accumulation and the administration of a secondary imaging agent into two sequential steps, offers the potential to improve image contrast and reduce radiation burden for nuclear imaging.
Lennart Bohrmann, Christian B M Poulie, Cristina Rodríguez-Rodríguez, Stoyan Karagiozov, Katayoun Saatchi, Matthias M Herth, Urs O Häfeli   +6 more
doaj   +1 more source

Peptide‐based Organocatalyst on Stage: Functionalizing Mesoporous Silica by Tetrazine‐Norbornene Ligation

ChemCatChem, 2023
AbstractOrganocatalysis via the enamine mechanism developed to one of the most relevant tools in carbonyl chemistry and is widely used in asymmetric organic synthesis. In this work, a strategy is presented to conveniently immobilize a peptide‐based catalyst on silica supports for use in continuous flow catalysis reactions.
Raoul D. Brand, Steffen A. Busche, Hans G. Börner, Bernd M. Smarsly   +3 more
openaire   +2 more sources

Tetrazine Functionalized Graphene Enables Capture of Ultra‐Low Concentrations of Biomacromolecules

Small, EarlyView.
A novel method for covalent modification of monolayer graphene utilizing tetrazine containing diazonium salt is demonstrated. The modified graphene bearing tetrazine moieties undergoes inverse electron demand Diels‐Alder reactions with trans‐cyclooctene‐linked molecules, enabling bioorthogonal attachment of nanobodies that selectively capture EGFP ...
Ravindra K. Gupta, Hanbin Jeong, April Goehring, Eric Gouaux, Maggie He   +4 more
wiley   +1 more source

Reactive precursor particles as synthetic platform for the generation of functional nanoparticles, nanogels, and microgels [PDF]

, 2019
Precise control of the chemical functionality of polymer nanoparticles is a key requirement in tailoring their (dynamic) colloidal properties toward advanced applications.
Gruber, Alexandra, Klinger, Daniel, Navarro, Lucila   +2 more
core   +1 more source

Bioorthogonal Ligation Using Site‐Specific Tetrazine‐Alkene Coupling On Proteins

The FASEB Journal, 2010
The selective coupling of chemical labels to proteins is key to many applications in medicine and biotechnology. Chemical labeling strategies require two functional groups to react rapidly and selectively with one another under biological conditions to form a stable covalent bond.
Christian André Refakis, Melissa L Blackman, Joseph M Fox, Ryan A Mehl   +3 more
openaire   +1 more source

Highly Stable and Selective Tetrazines for the Coordination-Assisted Bioorthogonal Ligation with Vinylboronic Acids [PDF]

Bioconjugate Chemistry, 2018
Bioorthogonal reactions are selective transformations that are not affected by any biological functional group and are widely used for chemical modification of biomolecules. Recently, we reported that vinylboronic acids (VBAs) gave exceptionally high reaction rates in the bioorthogonal inverse electron-demand Diels-Alder (iEDDA) reaction with ...
Selma Eising, Anthonius H. J. Engwerda, Xian Riedijk, F. Matthias Bickelhaupt, Kimberly M. Bonger   +4 more
openaire   +4 more sources