Results 71 to 80 of about 2,522 (183)

Isomeric triazines exhibit unique profiles of bioorthogonal reactivity. [PDF]

, 2019
Expanding the scope of bioorthogonal reactivity requires access to new and mutually compatible reagents. We report here that 1,2,4-triazines can be tuned to exhibit unique reaction profiles with biocompatible strained alkenes and alkynes.
Briggs, Jeffrey S, Houk, KN, Kamber, David N, Liang, Yong, Liu, Fang, Long, Zane G, Nguyen, Sean S, Prescher, Jennifer A, Row, R David, Shih, Hui-Wen   +9 more
core  

Engineering cell surfaces by covalent grafting of synthetic polymers to metabolically-labeled glycans [PDF]

, 2018
Re-engineering mammalian cell surfaces enables modulation of their phenotype, function, and interactions with external markers and may find application in cell-based therapies.
Bailey, Trisha L., Gibson, Matthew I., Martyn, Benjamin T., Tomás, Ruben M. F.   +3 more
core   +2 more sources

A High Energy Barrier DyIII2 Single‐Molecule Magnet Supported by a Bulky, Anionic N–O Bridging Ligand

Chemistry – A European Journal, EarlyView.
Complex [Dy2(hynad)2(dbm)4] was prepared by the employment of the anionic N–O‐based bridging and chelating N‐hydroxy‐1,8‐naphthalimide ligand, featuring a {Dy2(µ‐OR)2}4+ core and exhibiting zero‐field SMM behavior with a Ueff value of 171 K and double‐S‐shaped hysteresis loops, open up to 3.5 K.
Alexandros S. Armenis, Concepción Molina‐Jirón, Konstantinos N. Pantelis, Wolfgang Wernsdorfer, Mario Ruben, Eufemio Moreno‐Pineda, Theocharis C. Stamatatos   +6 more
wiley   +1 more source

A One-Pot Three-Component Double-Click Method for Synthesis of [67Cu]-Labeled Biomolecular Radiotherapeutics

Scientific Reports, 2017
A one-pot three-component double-click process for preparing tumor-targeting agents for cancer radiotherapy is described here. By utilizing DOTA (or NOTA) containing tetrazines and the TCO-substituted aldehyde, the two click reactions, the tetrazine ...
Katsumasa Fujiki, Shinya Yano, Takeshi Ito, Yuki Kumagai, Yoshinori Murakami, Osamu Kamigaito, Hiromitsu Haba, Katsunori Tanaka   +7 more
doaj   +1 more source

Radical Fluoroalkylation Reactions [PDF]

, 2018
Recent protocols and reactions for catalytic radical perfluoroalkylations will be described. The production of perfluoroalkyl radicals (RF = CnF2n+1, n ≥ 2), which effect both addition and substitution reactions on organic substrates, can be realized ...
Barata Vallejo, Sebastian, Cooke, María Victoria, Postigo, A.   +2 more
core   +1 more source

Tetrazine Ligation in Living Systems: Beyond Fast Kinetics to Effective Bioorthogonality

Chemistry – A European Journal, EarlyView.
Rapid reaction kinetics (k2) alone do not ensure successful tetrazine ligation in living systems. This review introduces ‘effective orthogonality’—focusing on chemical survival, availability, and encounter—as a practical framework. We highlight how bottlenecks shift from cellular sinks to in vivo delivery limits, offering design strategies for reliable
Junhyeong Yim, Junyoung Park, Youngjun Lee, Jongmin Park   +3 more
wiley   +1 more source

2016 EMBO Chemical Biology Conference [PDF]

, 2017
From August 31st- September 3rd the biennual EMBO Chemical Biology conference, hosted by the European Molecular Biology Laboratory (EMBL) in Heidelberg took place.
Bantscheff, Beans, Beck, Beer, Bergamini, Blatter, Buntz, Carette, Chatterjee, Chouchani, Chowdhury, Conway, Dittmann, Du, Ferreras, Frank, Gaali, Hackl, Heinis, Holt, Höfer, Jia, Jones, Jung, Kapp, Kollmannsperger, Komor, Labòria, Lechner, Lun, Makley, Mapp, Melo Czekster, Minoshima, Nadler, Niinivehmas, Nikic, Pao, Pianowski, Plass, Prier, Renata, Schoffelen, Sellmyer, Winter, Yamagishi, Zheng   +46 more
core   +2 more sources

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

Macromolecular Rapid Communications, EarlyView.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source

Toward Personalized Stationary Chromatography Phases: Equipping Commercial Silica Phases with Selected Peptide‐Based Binding Domains to Tailor Affinity

Advanced Materials Interfaces
A set of peptide‐functionalized mesoporous silica particles is synthesized by chemoselective inverse electron‐demand Diels‐Alder (IEDDA) ligation, exploiting the robust and cost‐effective norbornene/tetrazine coupling chemistry.
Steffen A. Busche, Lukas D. Bangert, Raoul D. Brand, Tommy Kröger, Enrico Heyl, Hans G. Börner   +5 more
doaj   +1 more source

Enhancing the performance of a mutant pyrrolysyl-tRNA synthetase to create a highly versatile eukaryotic cell-free protein synthesis tool [PDF]

, 2023
Modification of proteins with a broad range of chemical functionalities enables the investigation of protein structure and activity by manipulating polypeptides at single amino acid resolution.
Dondapati, Srujan K., Kubick, Stefan, Meyer, Manpreet, Schloßhauer, Jeffrey L., Thoring, Lena, Zemella, Anne   +5 more
core   +1 more source