Results 91 to 100 of about 2,522 (183)

Design and Synthesis of Highly Reactive Dienophiles for the Tetrazine– trans- Cyclooctene Ligation [PDF]

Journal of the American Chemical Society, 2011
Computation was used to design a trans-cyclooctene derivative that displays enhanced reactivity in the tetrazine-trans-cycloctene ligation. The optimized derivative is an (E)-bicyclo[6.1.0]non-4-ene with a cis-ring fusion, in which the eight-membered ring is forced to adopt a highly strained 'half-chair' conformation.
Michael T, Taylor, Melissa L, Blackman, Olga, Dmitrenko, Joseph M, Fox   +3 more
openaire   +2 more sources

Site‐Specific Surface Modification via Chemoselective Click Reactions on Cyclobutene‐Functionalized Monolayers

ChemistryOpen, Volume 15, Issue 4, April 2026.
ABSTRACT We report the first example of self‐assembled monolayers (SAMs) incorporating a cyclobutene‐substituted alkanethiol on a gold surface and the efficient modification of these monolayers via inverse electron‐demand Diels–Alder (IEDDA) cycloadditions.
Boone W. Evans, Kenneth N. Hipp, William D. Lambert, Wantanee Sittiwong, Rebecca Y. Lai, Patrick H. Dussault   +5 more
wiley   +1 more source

Tetrazine Amino Acid Encoding for Rapid and Complete Protein Bioconjugation

Bio-Protocol
Generating protein conjugates using the bioorthogonal ligation between tetrazines and trans-cyclooctene groups avoids the need to manipulate cysteine amino acids; this ligation is rapid, site-specific, and stoichiometric and allows for labeling of ...
Alex Eddins, Abigail Pung, Richard Cooley, Ryan Mehl   +3 more
doaj   +1 more source

Human Vault Nanoparticle Targeted Delivery of Antiretroviral Drugs to Inhibit Human Immunodeficiency Virus Type 1 Infection. [PDF]

, 2019
"Vaults" are ubiquitously expressed endogenous ribonucleoprotein nanoparticles with potential utility for targeted drug delivery. Here, we show that recombinant human vault nanoparticles are readily engulfed by certain key human peripheral blood ...
Anton, Peter A, Deming, Timothy, Elliott, Julie, Fulcher, Jennifer A, Ibarrondo, F Javier, Kickhoefer, Valerie A, Maynard, Heather D, Mrazek, Jan, Rome, Leonard H, Tamshen, Kyle, Wollenberg, Alexander L, Yang, Otto O   +11 more
core  

High-Sensitivity Fluorometry to Resolve Ion Channel Conformational Dynamics [PDF]

, 2018
Fluorescent labels offer the capability to follow conformational dynamics of membrane proteins, but signal detection in such recordings is inherently difficult to achieve in a cell membrane and lacks sufficient time resolution to follow physiologically ...
Pless, Stephan Alexander, Wulf, Matthias
core   +2 more sources

Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley   +1 more source

Impact of Docking Strand Design on Spatial Resolution in DNA‐Points Accumulation for Imaging in Nanoscale Topography

ChemPhysChem, Volume 27, Issue 5, 13 March 2026.
The design of DNA‐PAINT docking strands critically influences spatial resolution and signal stability. By comparing single (1 × R1) and repetitive (5 × R1) docking architectures on PCNA, we reveal how binding kinetics and localization precision determine the accuracy of sub‐10 nm imaging in protein nanostructures. DNA points accumulation for imaging in
Dominic A. Helmerich, Made Budiarta, Patrick Eiring, Markus Sauer, Sören Doose, Gerti Beliu   +5 more
wiley   +1 more source

A catalyst-free bioorthogonal reaction for malononitrile addition to azodicarboxylates

Nature Communications
Developing bioorthogonal reactions that enable fundamental exploration of biological processes remains a key pursuit of chemical biology. We report here malononitrile addition to azodicarboxylate as a distinct class of catalyst-free bioorthogonal ...
Honggui Huang, Xingyu Liu, Qianqian Qi, Hannan Chen, Haiyan Zhang, Kaisong Zhang, Xinyan Xu, Yunting Zhao, Xiang Zhou, Wenbo Liu, Tian Tian   +10 more
doaj   +1 more source

Surface behavior and reactivity of dialkylated tetrazine with norbornene at the air–water interface

Next Materials
The inverse electron-demand Diels–Alder (IEDDA) reaction is a powerful tool for bioorthogonal chemistry and materials engineering, yet its efficiency at structurally confined interfaces remains incompletely understood.
Hiromichi Nakahara, Masayori Hagimori, Kento Kannaka, Takahiro Mukai, Osamu Shibata   +4 more
doaj   +1 more source

Click Chemistry and Bioorthogonal Reaction for Aggregation‐Induced Emission Bioconjugates

Aggregate, Volume 7, Issue 3, March 2026.
This review highlights the construction of AIE active bioconjugates via click chemical or bioorthogonal reactions, and their applications in biosensing, bioimaging, and image‐guided treatment. The challenges and perspectives in the area are also discussed.
Xinzhe Yang, Miaomiao Kang, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source