Results 61 to 70 of about 2,522 (183)
Multivalent glycan arrays [PDF]
, 2019 Glycan microarrays have become a powerful technology to study biological processes, such as cell–cell interaction, inflammation, and infections. Yet, several challenges, especially in multivalent display, remain.
Bordoni, Vittorio +5 more
core +1 more source
π-Clamp-mediated cysteine conjugation [PDF]
, 2014 Site-selective functionalization of complex molecules is one of the most significant challenges in chemistry. Typically, protecting groups or catalysts must be used to enable the selective modification of one site among many that are similarly reactive ...
Pentelute, Bradley L. +6 more
core +1 more source
Design, synthesis, conjugation and reactivity of novel trans,trans-1,5-cyclooctadiene-derived bioorthogonal linkers [PDF]
, 2020 Funding Information: The authors thank Irene Feiner, Marion van Leeuwen-Chomet, and Joey Muns for their helpful insight. We acknowledge financial support from the University of Aberdeen and European Union’s Horizon 2020 research and innovation programme ...
Baldassarre, Massimiliano +7 more
core +1 more source
Radiolabeled albumin through SNAr of cysteines as a potential pretargeting theranostic agent [PDF]
, 2022 Human serum albumin (HSA) has been shown to be a promising tumor targeting vector and target for generating theranostics by bioconjugation. Unstable chemical conjugation to HSA via a cysteine (Cys34) by reversible Michael additions is most commonly ...
Diness, Frederik +3 more
core +2 more sources
Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET [PDF]
, 2016 Protein kinases share significant structural similarity; however, structural features alone are insufficient to explain their diverse functions. Thus, bridging the gap between static structure and function requires a more detailed understanding of their ...
Alexandrov, Y +11 more
core +1 more source
Angewandte Chemie International Edition, EarlyView.Tuning the rate of covalent network formation in hybrid double network hydrogels regulates whether supramolecular filaments retain their low‐nm structures or depletion‐induced supramolecular assembly takes place forming bundles. This kinetic handle programs the mesoscale architecture and toughness of the hydrogels, establishing a link between ...
Mertcan Özel +7 more
wiley +1 more source
Chapter Pretargeted Theranostics [PDF]
, 2021 Personalized medicine is becoming an integral part of our healthcare system, in which theranostics play a fundamental role. Nanomedicines such as monoclonal antibodies are a commonly used targeting vector in such approaches due to their outstanding ...
B.M. Poulie, Christian +2 more
core +1 more source
Genetic code expansion for chemosensing and chemical actuation of biological functions
Bulletin of the Korean Chemical Society, EarlyView.Genetic code expansion (GCE) broadens the chemical repertoire for precise control of protein function in biological systems. This review highlights GCE‐based sensing and actuating systems that operate through selective interactions between noncanonical amino acids and chemical triggers.
Jieun Bae, Dong‐Hyun Kim, Minseob Koh
wiley +1 more source
Synthesis of non-linear protein dimers through a genetically encoded thiol-ene reaction [PDF]
, 2014 Site-specific incorporation of bioorthogonal unnatural amino acids into proteins provides a useful tool for the installation of specific functionalities that will allow for the labeling of proteins with virtually any probe.
Chou, C +3 more
core +3 more sources
Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers
Chemistry – A European Journal, EarlyView.ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda +5 more
wiley +1 more source