Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models [PDF]
, 2017 Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient.
Airaksinen, Anu +9 more
core +2 more sources
Molecular Imaging, 2013 18 F positron emission tomography (PET) has a number of attributes that make it clinically attractive, including nearly 100% positron efficiency, very high specific radioactivity, and a short half-life of ≈ 110 minutes. However, the short half-life of 18
Shuanglong Liu +9 more
doaj +1 more source
Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice [PDF]
, 2012 Background—Exaggerated and prolonged inflammation after myocardial infarction (MI) accelerates left ventricular remodeling. Inflammatory pathways may present a therapeutic target to prevent post-MI heart failure.
Anderson, Daniel Griffith +20 more
core +1 more source
Facile, productive, and cost-effective synthesis of a novel tetrazine-based iron oxide nanoparticle for targeted image contrast agents and nanomedicines [PDF]
, 2018 We have developed an operationally simple, time, and cost-effective protocol to produce a novel tetrazine-based iron oxide nanoparticle using commercially available and inexpensive materials.
A Kuzmin +24 more
core +3 more sources
A Minimal, Unstrained S-Allyl Handle for Pre-Targeting Diels-Alder Bioorthogonal Labeling in Live Cells [PDF]
, 2016 The unstrained S-allyl cysteine amino acid was site-specifically installed on apoptosis protein biomarkers and was further used as a chemical handle and ligation partner for 1,2,4,5-tetrazines by means of an inverse-electron-demand Diels-Alder reaction ...
, +6 more
core +4 more sources
Bioorthogonal fluorescent labels: a review on combined forces [PDF]
, 2015 This review ventures to summarize the latest developments in bioorthogonal fluorescent imaging labels with a special focus on bioimaging applications. We briefly summarize the most preferred means of bioorthogonal tagging schemes for the labeling
Cserép, Balázs Gergely +2 more
core +1 more source
Direct imaging of glycans in Arabidopsis roots via click labeling of metabolically incorporated azido-monosaccharides [PDF]
, 2016 Background: Carbohydrates, also called glycans, play a crucial but not fully understood role in plant health and development. The non-template driven formation of glycans makes it impossible to image them in vivo with genetically encoded fluorescent tags
Dario Cramer +5 more
core +10 more sources
Recent Trends in Bioorthogonal Click-Radiolabeling Reactions Using Fluorine-18
Molecules, 2013 The increasing application of positron emission tomography (PET) in nuclear medicine has stimulated the extensive development of a multitude of novel and versatile bioorthogonal conjugation techniques especially for the radiolabeling of biologically ...
Doreen Pietzsch +2 more
doaj +1 more source
Recent advances in crosslinking chemistry of biomimetic poly(ethylene glycol) hydrogels [PDF]
, 2015 The design and application of biomimetic hydrogels have become an important and integral part of modern tissue engineering and regenerative medicine. Many of these hydrogels are prepared from synthetic macromers (e.g., poly(ethylene glycol) or PEG) as ...
Lin, Chien-Chi
core +1 more source
Bio-orthogonal Fluorescent Labelling of Biopolymers through Inverse-Electron-Demand Diels–Alder Reactions [PDF]
, 2017 Bio-ort hogona llabellin gschemes based on inverse-elec tron- deman dDiels–Ald er (IEDDA) cycloa ddition have attracted much attention in chem ical biology recently .The appeal ing features of this reactio n, such as the fast ...
Agard +110 more
core +1 more source