Comparative Analysis of Apigenin-3 Acetate versus Apigenin and Methyl-Prednisolone in Inhibiting Proliferation and Gene Expression of Th1 Cells in Multiple Sclerosis [PDF]
Cell Journal, 2023 Objective: In spite of the advances in therapeutic modalities, morbidity, due to multiple sclerosis (MS), still remains high.Therefore, a large body of research is endeavouring to discover or develop novel therapies with improved efficacy fortreating MS ...
Neda Kasiri +7 more
doaj +1 more source
In Vivo CD4+ T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm.
Annual Review of Immunology, 2020 The discovery of CD4+ T cell subset-defining master transcription factors and framing of the Th1/Th2 paradigm ignited the CD4+ T cell field.
Mikel Ruterbusch +3 more
semanticscholar +1 more source
Further Checkpoints in Th1 Development [PDF]
Immunity, 2002 Tight control of Th1 immunity is essential to prevent immunopathology. Central to control of the IFN-gamma gene is the transcription factor T-bet, whose induction is Stat-1 dependent. IL-12 is dominant in directing Th1 development, while synergizing with IL-18 for IFNgamma production from differentiated Th1 cells.
Anne O'Garra, Douglas S. Robinson
openaire +3 more sources
Frontiers in Immunology, 2020 During pregnancy, various immune effectors and molecules participating in the immune-microenvironment establish specific maternal tolerance toward the semi-allogeneic fetus.
Wen-juan Wang +3 more
semanticscholar +1 more source
Th1/Th2 Imbalance and Elevated PD-L1 in Pleural Effusion Predict the Risk of Multi-Drug Resistant Tuberculous Pleuritis [PDF]
Iranian Journal of Immunology, 2020 Background: Patient immune status might be indicative of the variance in bacterial genetics in drug-resistant tuberculous pleuritis and could be used for predicting the risk of multi-drug resistant tuberculous pleuritis (MDR-TB).
Hongyan Xu +3 more
doaj +1 more source
Interleukin-33 promoting Th1 lymphocyte differentiation dependents on IL-12 [PDF]
, 2016 No abstract available.The pro-Th2 cytokine IL-33 is now emerging as an important Th1 cytokine-IFN-γ inducer in murine CD4+ T cells that is essential for protective cell-mediated immunity against viral infection in mice. However, whether IL-33 can promote
Komai-Koma, Mousa +5 more
core +1 more source
Histopathologic and immunological features of Imiquimod induced psoriatic mouse model
Pifu-xingbing zhenliaoxue zazhi, 2019 Objective: To investigate the dermatopathologic and immunological features of Imiquimod induced psoriatic mice model. Methods: Twenty BALB/c mice were grouped in IMQ-model group and control group randomly, each had 10 mice.
Zhong-zhou HUANG +5 more
doaj +1 more source
Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus [PDF]
, 2019 During aging, glutathione (GSH) content declines and the immune system undergoes a deficiency in the induction of Th1 response. Reduced secretion of Th1 cytokines, which is associated with GSH depletion, could weaken the host defenses against viral ...
Amatore, D +9 more
core +1 more source
Journal of Immunotoxicology, 2020 The prevalence of iron (Fe) deficiency and subclinical lead (Pb) toxicity is high in developing countries like India, and information on their potential additive effects on immune responses is scant.
Srinivasa Reddy Yathapu +4 more
doaj +1 more source
Restoring Lost Anti-HER-2 Th1 Immunity in Breast Cancer: A Crucial Role for Th1 Cytokines in Therapy and Prevention [PDF]
, 2016 The ErbB/B2 (HER-2/neu) oncogene family plays a critical role in the development and metastatic spread of several tumor types including breast, ovarian and gastric cancer.
Czerniecki, Brian J. +4 more
core +2 more sources