Comparative Analysis of Apigenin-3 Acetate versus Apigenin and Methyl-Prednisolone in Inhibiting Proliferation and Gene Expression of Th1 Cells in Multiple Sclerosis [PDF]
Cell Journal, 2023 Objective: In spite of the advances in therapeutic modalities, morbidity, due to multiple sclerosis (MS), still remains high.Therefore, a large body of research is endeavouring to discover or develop novel therapies with improved efficacy fortreating MS ...
Neda Kasiri +7 more
doaj +1 more source
Game theory applications in host-microbe interactions toward disease manifestation: Mycobacterium tuberculosis infection as an example [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Game theory describes the interactions between two players and the pay-off from winning, losing, or compromising. In the present study, Mycobacterium tuberculosis (Mtb)–host interactions were used as an example for the application of game ...
Hiva Sharebiani +11 more
doaj +1 more source
Th2/Th1 Cytokine Imbalance Is Associated With Higher COVID-19 Risk Mortality
Frontiers in Genetics, 2021 A major component of COVID-19 severe respiratory syndrome is the patient’s immune response to the SARS-CoV-2 virus and the consequential multi-organ inflammatory response.
A. Pavel +5 more
semanticscholar +1 more source
In Vivo CD4+ T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm.
Annual Review of Immunology, 2020 The discovery of CD4+ T cell subset-defining master transcription factors and framing of the Th1/Th2 paradigm ignited the CD4+ T cell field.
Mikel Ruterbusch +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2020 During pregnancy, various immune effectors and molecules participating in the immune-microenvironment establish specific maternal tolerance toward the semi-allogeneic fetus.
Wen-juan Wang +3 more
semanticscholar +1 more source
Th1/Th2 Imbalance and Elevated PD-L1 in Pleural Effusion Predict the Risk of Multi-Drug Resistant Tuberculous Pleuritis [PDF]
Iranian Journal of Immunology, 2020 Background: Patient immune status might be indicative of the variance in bacterial genetics in drug-resistant tuberculous pleuritis and could be used for predicting the risk of multi-drug resistant tuberculous pleuritis (MDR-TB).
Hongyan Xu +3 more
doaj +1 more source
A novel transcription factor, T-bet, directs Th1 lineage commitment.
Cell, 2000 Naive T helper cells differentiate into two subsets, Th1 and Th2, each with distinct functions and cytokine profiles. Here, we report the isolation of T-bet, a Th1-specific T box transcription factor that controls the expression of the hallmark Th1 ...
S. Szabo +5 more
semanticscholar +1 more source
Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus [PDF]
, 2019 During aging, glutathione (GSH) content declines and the immune system undergoes a deficiency in the induction of Th1 response. Reduced secretion of Th1 cytokines, which is associated with GSH depletion, could weaken the host defenses against viral ...
Amatore, D +9 more
core +1 more source
Histopathologic and immunological features of Imiquimod induced psoriatic mouse model
Pifu-xingbing zhenliaoxue zazhi, 2019 Objective: To investigate the dermatopathologic and immunological features of Imiquimod induced psoriatic mice model. Methods: Twenty BALB/c mice were grouped in IMQ-model group and control group randomly, each had 10 mice.
Zhong-zhou HUANG +5 more
doaj +1 more source
B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response [PDF]
, 2013 We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by
A Casadevall +74 more
core +9 more sources