Results 251 to 260 of about 230,695 (309)

Biomarkers for successful tapering of a tumor necrosis factor inhibitor in patients with radiographic axial spondyloarthritis: A pilot study. [PDF]

SAGE Open Med
Min HK, Lee JY.
europepmc   +1 more source

Impairment of Innate Immunity and Depletion of Vaccine‐Induced Memory B and T Cells in the Absence of the Spleen

American Journal of Hematology, Volume 100, Issue 5, Page 770-784, May 2025.
ABSTRACT Splenectomy or congenital asplenia is associated with severe reduction of memory B cells and increased risk of fulminant sepsis by encapsulated bacteria. Current guidelines recommend vaccinations against these pathogens before or after splenectomy, but the longevity of immunity acquired after splenectomy has not been determined.
Veronica Bordoni, Bianca Laura Cinicola, Eva Piano Mortari, Concetta Castilletti, Federica Guarracino, Christian Albano, Silvia Accordini, Anwar Baban, Antonio Di Sabatino, Carlo Maria Rossi, Marco Vincenzo Lenti, Anna Maria Zicari, Riccardo Cirelli, Marco Spada, Gian Luca Forni, Isabella Quinti, Mattia Algeri, Maddalena Casale, Silverio Perrotta, Franco Locatelli, Chiara Agrati, Rita Carsetti   +21 more
wiley   +1 more source

Abnormal glucose and lipid metabolism promotes disrupted differentiation of T and B cell subsets in Behçet's disease. [PDF]

Immunother Adv
Li M, Li P, Wang X, Wang L, Gao G, Jiang G, Liu T, Lin W.   +7 more
europepmc   +1 more source

Biodiversity of the Bacterial and Fungal Microbiome and Associated Inflammatory Cytokine Profile in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, Volume 15, Issue 5, Page 502-512, May 2025.
ABSTRACT Background Dysbiosis of the bacterial and fungal microbiome has been increasingly implicated in the pathogenesis of chronic rhinosinusitis (CRS). This study explores the relationship between microbiome and mycobiome biodiversity and type 2 (T2) versus non‐type 2 (NT2) inflammation.
Hong‐Ho Yang, Carra A Simpson, Meera Srivastava, Alakesh Bera, Monica Cappelletti, Jeffrey D. Suh, Marilene B. Wang, Daniel M. Beswick, Tom Maxim, Saroj K. Basak, Eri S. Srivatsan, Jakob L. Fischer, Jonathan P Jacobs, Jivianne T. Lee   +13 more
wiley   +1 more source

Post-exposure vaccine protection of CTH522/CAF^®01 against reinfection with Chlamydia trachomatis requires Th1/Th17 but not Th2-immunity. [PDF]

NPJ Vaccines
Nguyen NDNT, Subratheepam S, Guleed S, Melchiors KM, Olsen AW, Wørzner K, Follmann F, Dietrich J.   +7 more
europepmc   +1 more source

Deficiency of DEK proto‐oncogene alleviates allergic rhinitis by inhibiting RhoA/Ezrin‐mediated mitochondrial fission

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the mechanism of DEK regulating RhoA activation Ezrin. Upon house dust mite (HDM) stimulation, HDM‐specific immunoglobulin E (IgE) and inflammatory factors such as interleukin 4 (IL‐4), IL‐5, IL‐13, and eosinophils increased in the nasal mucosa.
Longzhu Dai, Yongde Jin, Jingmei Chai, Jianing Yang, Jiangang Wang, Mu Chen, Liangchang Li, Chongyang Wang, Guanghai Yan   +8 more
wiley   +1 more source

The function of T cells in immune thrombocytopenia. [PDF]

Front Immunol
Bu S, Liu M, Yang L, Lee P, Miller H, Park CS, Byazrova M, Filatov A, Benlagha K, Gaber T, Buttgereit F, Gong Q, Zhai Z, Liu C.   +13 more
europepmc   +1 more source

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source

Comparative analysis of short‐term and long‐term LL‐37‐induced rosacea‐like mouse models: Histopathological features and inflammatory immune responses

Animal Models and Experimental Medicine, EarlyView.
The aim of this study was to improve the long‐term LL‐37 mouse model and compare the disease manifestations and pathophysiology of short‐term and long‐term LL‐37‐induced rosacea‐like models. The results show that the long‐term LL‐37 induced mouse model provides a practical animal model for further study of the pathological mechanism of severe rosacea ...
Yiling Wu, Chuanxi Zhang, Hui Jin, Ruiping Zheng, Tian Li, Fuyu Jin, Yaqian Li, Xuemin Gao, Hong Xu, Zhongqiu Wei, Jie Yang   +10 more
wiley   +1 more source

Th1/Th2 Immune Imbalance in the Spleen of Mice Induced by Hypobaric Hypoxia Stimulation and Therapeutic Intervention of Astragaloside IV. [PDF]

Int J Mol Sci
Gao R, Wu Z, Dang W, Yang T, Chen J, Cheng H, Cui J, Lin L, Shen X, Li F, Yan J, Gao Y, Gao Y, Ma Z.   +13 more
europepmc   +1 more source