Results 71 to 80 of about 319,332 (247)

Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142

Brazilian Journal of Medical and Biological Research, 2019
The aim of this study was to evaluate the influence of artesunate on Th1 differentiation and its anti-tumor effect on ovarian cancer. A Murine ovarian cancer model was established by ID8 cells transplantation. The expression of miR-142 and Sirt1 proteins
Xiao Chen, Xue-ling Zhang, Guo-hua Zhang, Ying-fang Gao   +3 more
doaj   +1 more source

Supplementary Figure 2 from Soluble IL6R Expressed by Myeloid Cells Reduces Tumor-Specific Th1 Differentiation and Drives Tumor Progression

, 2023
Hirotake Tsukamoto, Koji Fujieda, Masatoshi Hirayama, Tokunori Ikeda, Akira Yuno, Keiko Matsumura, Daiki Fukuma, Kimi Araki, Hiroshi Mizuta, Hideki Nakayama, Satoru Senju, Yasuharu Nishimura   +11 more
openalex   +1 more source

In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines

Journal of Experimental Medicine, 2002
We show that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4+ T cells to differentiate in vitro into regulatory T cells.
F. Barrat, D. Cua, A. Boonstra, D. Richards, C. Crain, H. Savelkoul, R. de Waal‐Malefyt, R. Coffman, C. Hawrylowicz, A. O’Garra   +9 more
semanticscholar   +1 more source

Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis.

PLoS ONE, 2010
BackgroundThere is consensus that experimental autoimmune encephalomyelitis (EAE) can be mediated by myelin specific T cells of Th1 as well as of Th17 phenotype, but the contribution of either subset to the pathogenic process has remained controversial ...
Helena S Domingues, Marsilius Mues, Hans Lassmann, Hartmut Wekerle, Gurumoorthy Krishnamoorthy   +4 more
doaj   +1 more source

Th1 Chemokines in Autoimmune Endocrine Disorders

The Journal of Clinical Endocrinology & Metabolism, 2019
AbstractContextThe CXC chemokine receptor CXCR3 and its chemokines CXCL10, CXCL9, and CXCL11 are implicated in the pathogenesis of autoimmune diseases. Here, we review these chemokines in autoimmune thyroiditis (AT), Graves disease (GD), thyroid eye disease (TED), type 1 diabetes (T1D), and Addison’s disease (AAD).Evidence AcquisitionA PubMed review of
Fallahi, Poupak, Ferrari, Silvia Martina, Ragusa, Francesca, Ruffilli, Ilaria, Elia, Giusy, Paparo, Sabrina Rosaria, Antonelli, Alessandro   +6 more
openaire   +3 more sources

Perioperative immune responses in cancer patients undergoing digestive surgeries

World Journal of Surgical Oncology, 2009
Background Th1/Th2 cell balance is thought to be shifted toward a Th2-type immune response not only by malignancy but also by surgical stress. The aim of this study was to estimate perioperative immune responses with respect to the Th1/Th2 balance in ...
Miyauchi Takayuki, Hanaki Norikazu, Nishioka Masanori, Ishikawa Masashi, Kashiwagi Yutaka, Ioki Hiromi, Kagawa Akihiro, Nakamura Yoichi   +7 more
doaj   +1 more source

Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer.

Cancer Research, 2011
The tumor microenvironment includes a complex network of immune T-cell subpopulations. In this study, we systematically analyzed the balance between cytotoxic T cells and different subsets of helper T cells in human colorectal cancers and we correlated ...
M. Tosolini, A. Kirilovsky, B. Mlecnik, T. Fredriksen, S. Mauger, G. Bindea, A. Berger, P. Bruneval, W. Fridman, F. Pagès, J. Galon   +10 more
semanticscholar   +1 more source

IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals.

PLoS Pathogens, 2013
The IL-27R, WSX-1, is required to limit IFN-γ production by effector CD4⁺ T cells in a number of different inflammatory conditions but the molecular basis of WSX-1-mediated regulation of Th1 responses in vivo during infection has not been investigated in
Ana Villegas-Mendez, J Brian de Souza, Seen-Wai Lavelle, Emily Gwyer Findlay, Tovah N Shaw, Nico van Rooijen, Christiaan J Saris, Christopher A Hunter, Eleanor M Riley, Kevin N Couper   +9 more
doaj   +1 more source

Indicii imunității la pacienții cu tuberculoză pulmonară sub influența tratamentului complex

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2019
La 49 de pacienți cu tuberculoză pulmonară asociată cu toxocaroză, care au urmat tratament standard antituberculos, antiparazitar și imunocorectiv, a fost studiată dinamica indicilor răspunsului imun Th1 și Th2 și prezența corelației IL-5 cu eozinofilia ...
Angela Guila, Natalia Zincenco, Corina Rotaru-Lungu, Serghei Ghinda, Valentina Chiroşca, Elena Privalova   +5 more
doaj  

PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment

Frontiers in Immunology
BackgroundInduced regulatory T cells (iTregs) are a heterogeneous population of immunosuppressive T cells with therapeutic potential. Treg cells show a range of plasticity and can acquire T effector-like capacities, as is the case for T helper 1 (Th1 ...
Nidhi Jadon, Sudarvili Shanthalingam, Gregory N. Tew, Lisa M. Minter, Lisa M. Minter   +4 more
doaj   +1 more source