Results 1 to 10 of about 260,137 (386)

The Endogenous Th17 Response in NO2-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer [PDF]

, 2013
Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease.
A Abe, A Duguet, A Hoshino, A Vazquez-Tello, A Vazquez-Tello, AG Besnard, AG Besnard, AI Caceres, AJ Coyle, AR Brasier, AR Sousa, AS Saffar, AT Hastie, B Korkmaz, Benjamin T. Suratt, BJ Canning, C Sutton, C Taube, D Stejskal, Daniel J. Weiss, DB Corry, DC Newcomb, DC Newcomb, DC Newcomb, DH Broide, E Goleva, F Kirstein, GJ Zijlstra, H Fujie, H Koga, H Wakashin, Hong Wei Chu, I Tillie-Leblond, J Agbetile, J Chang, J Seok, J Sunyer, J Zhao, JB Cowland, Jennifer L. Ather, JH Bates, JH Lee, JL Ather, JL Ather, John F. Alcorn, JR Karlsen, JV Fahy, K Raemdonck, K Yang, L McKinley, LA Cooney, Laura Hoyt, Lennart K. A. Lundblad, LJ Akinbami, LK Lundblad, LK Lundblad, LK Lundblad, LL Reber, M Bevelander, M Kawaguchi, M Kudo, M Leppkes, M Suzukawa, MA Willart, Matthew E. Poynter, ME Poynter, ME Poynter, ME Poynter, MH Brutsche, MH Shaw, MW Kinyanjui, N Schmitz, PA Wark, PL Delamater, PS Foster, PW Hellings, Q Wang, R He, RA Martin, Rebecca A. Martin, Rebecca Daggett, RH Wilson, S Ano, S Dragon, S Ferretti, S Haak, S Lajoie, S Molet, S Schnyder-Candrian, S Suzuki, S Wenzel, SJ Ballantyne, SM Hu, SP Chapoval, SR Hodgkins, T Li, VJ Johnson, W Al-Ramli, WP Arend, WW Lee, X Yao, XY Chi, Y Chung, Y Liu, Y Takenoue, Y Zhao, YH Wang   +106 more
core   +16 more sources

Intricacies of TGF-β signaling in Treg and Th17 cell biology

Cellular & Molecular Immunology, 2023
Balanced immunity is pivotal for health and homeostasis. CD4^+ helper T (Th) cells are central to the balance between immune tolerance and immune rejection. Th cells adopt distinct functions to maintain tolerance and clear pathogens.
Junying Wang, Xingqi Zhao, Y. Wan
semanticscholar   +1 more source

Intrauterine administration of peripheral blood mononuclear cells (PBMCs) improves embryo implantation in mice by regulating local Treg/Th17 cell balance

The Journal of Reproduction and Development, 2021
Immune imbalance of Treg/Th17 cells may contribute to recurrent implantation failure (RIF) during in vitro fertilization and embryo transfer (IVF-ET). In this study, we sought to determine the effect of intrauterine administration of mouse PBMCs prior to
Lei FAN, Menghan SHA, Wei LI, Qingling KANG, Jianli WU, Suhua CHEN, Nan YU   +6 more
doaj   +1 more source

Lactobacillus rhamnosus GG ameliorates osteoporosis in ovariectomized rats by regulating the Th17/Treg balance and gut microbiota structure

Gut microbes, 2023
Background With increasing knowledge about the gut – bone axis, more studies for treatments based on the regulation of postmenopausal osteoporosis by gut microbes are being conducted.
Mengyu Guo, Huanjin Liu, Yin-Ping Yu, Xingyu Zhu, Hui Xie, Chenxu Wei, Chunmei Mei, Yun Shi, Nong Zhou, Kunming Qin, Weidong Li   +10 more
semanticscholar   +1 more source

The role of Th17 cells in inflammatory bowel disease and the research progress

Frontiers in Immunology, 2023
Th17 cells play an important role in the abnormal immune response in inflammatory bowel disease (IBD) and are involved in the development and progression of inflammation and fibrosis. An increasing amount of data has shown that gut microbes are important
Lu Chen, Guangcong Ruan, Yi Cheng, Ailin Yi, Dongfeng Chen, Yanling Wei   +5 more
semanticscholar   +1 more source

Th17/Treg Imbalance: Implications in Lung Inflammatory Diseases

International Journal of Molecular Sciences, 2023
Regulatory T cells (Tregs) and T helper 17 cells (Th17) are two CD4+ T cell subsets with antagonist effects. Th17 cells promote inflammation, whereas Tregs are crucial in maintaining immune homeostasis.
Rony Thomas, Sai Qiao, Xi Yang
semanticscholar   +1 more source

Pharmacological Inhibition of PPAR_y Boosts HIV Reactivation and Th17 Effector Functions, while Preventing Progeny Virion Release and de novo Infection

Pathogens and Immunity, 2020
The frequency and functions of Th17-polarized CCR6+RORyt+CD4+ T cells are rapidly compromised upon HIV infection and are not restored with long-term viral suppressive antiretroviral therapy (ART).
Delphine Planas, Augustine Fert, Yuwei Zhang, Jean-Philippe Goulet, Jonathan Richard, Andrés Finzi, Maria Julia Ruiz, Laurence Raymond Marchand, Debashree Chatterjee, Huicheng Chen, Tomas Raul Wiche Salinas, Annie Gosselin, Eric A. Cohen, Jean-Pierre Routy, Nicolas Chomont, Petronela Ancuta   +15 more
doaj   +1 more source

Identification of Th1-polarized Th17 cells: solving the problem

Медицинская иммунология, 2023
Helper T cells producing IL-17 (Th17) have high plasticity: restimulation of lymphocytes in an inflammatory environment can induce their transformation into cells with another phenotype, and a shift towards Th1 is the most common.
E. M. Kuklina, N. S. Glebezdina
doaj   +1 more source

Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2

Nature Communications, 2022
Neutrophils perform critical functions in the innate response to infection, including through the production of neutrophil extracellular traps (NETs) - web-like DNA structures which are extruded from neutrophils upon activation.
Alicia S. Wilson, Katrina L. Randall, J. Pettitt, J. Ellyard, A. Blumenthal, A. Enders, B. Quah, T. Bopp, C. Parish, A. Brüstle   +9 more
semanticscholar   +1 more source

Content of CD4⁺T cell subpopulations in predicting the efficacy of biological therapy for psoriasis in children

Медицинская иммунология, 2023
Psoriasis is a chronic inflammatory skin disease characterized by increased proliferation of epidermal cells, impaired keratinization and an inflammatory reaction in dermis caused by activation of T lymphocytes and synthesis of pro-inflammatory cytokines.
D. G. Kuptsova, T. V. Radigina, O. V. Kurbatova, A. I. Materikin, R. V. Epishev, L. A. Opryatin, A. A. Khotko, N. N. Murashkin, S. V. Petrichuk   +8 more
doaj   +1 more source