Results 251 to 260 of about 212,593 (289)

Network pharmacological and experimental validation of the mechanism of Chaihu Guizhi Ganjiang decoction regulating T helper cell 17/regulatory T cell balance to improve autoimmune hepatitis. [PDF]

J Tradit Chin Med
Zihao L, Jie G, Jinyun S, Qin Z, Hongyu Z.   +4 more
europepmc   +1 more source

G Protein–Coupled Receptors in Olfactory Signaling and Related Disorders: Mechanisms and Therapeutic Implications

Sensory Neuroscience, EarlyView.
This schematic highlights GPCRs as the central hub of olfactory signaling in health and disease. The central GPCR shows odorant activation and downstream pathways. Surrounding quadrants illustrate four GPCR‐mediated themes: odor perception and adaptation, mucosal immunity and regeneration, memory consolidation via neural circuits, and GPCR‐related ...
Zishuo Guo, Hongjie Du, Fanyu Yuan, Yuhan Dong, Fangyuan Zhu, Jian Liu, Chengzhilin Li, Xu Guo, Zhaoze Yang, Wenwen Qi, Ming Xia, Chengcheng Liu   +11 more
wiley   +1 more source

The imbalance of Th17/Treg cells exists in asymptomatic hyperuricemia (the early stage of gout). [PDF]

Clin Rheumatol
Zhang LQ, Zhao LJ, Qin AL, Wen QY, Gao C, Li XF.   +5 more
europepmc   +1 more source

Bile acid metabolism and sleep: Mechanistic interplay and clinical implications of the gut–liver–brain axis

Sleep Research, EarlyView.
Abstract The bidirectional interplay between sleep and metabolic homeostasis is fundamental to physiological health. While the roles of glucose and lipid metabolism in sleep regulation have been extensively characterized, bile acids (BAs), which are traditionally viewed as digestive surfactants, are emerging as critical metabolic messengers with ...
Yu Jiang, Shuangyan Li, Dhirendra Paudel, Miaoqin Tan, Bin Zhang   +4 more
wiley   +1 more source

Inhibition of IL-6/STAT3 Signaling by N-Trans-Hibiscusamide and Its Derivative in a Mouse Model of Collagen-Induced Arthritis. [PDF]

Food Sci Nutr
Lim HJ, Bak SG, Bae J, Chandimali N, Park EJ, Lee SW, Kim M, Lee SH, Won YS, Cheong SH, Lee SJ.   +10 more
europepmc   +1 more source

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission

Small, EarlyView.
Engineered malaria antigens enable in vivo bioconjugation to submicron biopolymer particles in E. coli. Two antigens are co‐tethered at high density and defined stoichiometry. The resulting thermostable particles elicit strong, durable antibody and T‐cell responses, conferring robust protection and blocking mosquito transmission.
Nivethika Sivakumaran, Yevel Flores‐Garcia, Chanel M. Naar, Shuxiong Chen, Mili Mehta, Fijs W. B. van Leeuwen, Abhai Tripathi, Rajagopal Murugan, Meta Roestenberg, Fidel Zavala, Bernd H. A. Rehm   +10 more
wiley   +1 more source

Selective disruption of RORγt-CBFβ interaction by IMU-935 prevents RORγt-dependent Th17 autoimmunity but not thymocyte development. [PDF]

J Clin Invest
Wu H, Zhong X, Ma N, He Z, Wang G, Lu G, Yuan YC, Zhang W, Shi Y, Vaidehi N, Peelen E, Wulff T, Gege C, Kohlhof H, Vitt D, Gwack Y, Taniuchi I, Xue HH, Sun Z.   +18 more
europepmc   +1 more source

The IDO1/AhR-HIF-1α metabolic axis: ARNT competition as a central antagonistic switch in autoimmune pathogenesis. [PDF]

Front Immunol
Dong Z, Dai H, Zhang X, Zhao Z, Chen Y, Zheng Y, Rui H, Liu B, Zhong X.   +8 more
europepmc   +1 more source

Interleukin-35 as a key immunoregulatory mediator in steroid-hyporesponsive severe asthma. [PDF]

Front Immunol
Al-Matouq J, Khalid Salah Al-Sheakly B, Saheb Sharif-Askari N, Halwani R, Saheb Sharif-Askari F.   +4 more
europepmc   +1 more source

A mouse model of allergic conjunctivitis with mucosal immune-related gene and circRNA dysregulation. [PDF]

Front Immunol
Zhang H, Qi Y, Leng Q, Qin Y, Zhang H, Wu B.   +5 more
europepmc   +1 more source