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The E3 ligases Itch and WWP2 regulate autoimmune neuroinflammation by controlling T_H2 to T_H17 cell conversion via interleukin-4-STAT5 axis in mice. [PDF]

Nat Commun
Zhao M, Zhang C, Zhang X, Mu Q, Li Q, Liu YC.   +5 more
europepmc   +1 more source

Heat-killed Lactobacillus johnsonii Directly Inhibits Th17 Cell Effector Function via Selective Translational Suppression

Zhou X, Chen C, Jansons S, Sun F, Bonger K, Moore B.   +5 more
europepmc   +1 more source

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Pharmacological Modulation of Th17

Recent Patents on Inflammation & Allergy Drug Discovery, 2009
Recently, a third subset of Th17 cells has been described. This T helper subset induces the release of chemokines and growth factors and causes neutrophil accumulation in several mammalian organs. Pharmacological intervention blocking Th17 generation as well as IL-17 signaling might prove useful in a variety of diseases including asthma, chronic ...
Juan B, De Sanctis, Jenny V, Garmendia, Dolores, Moreno, Nancy, Larocca, Michael, Mijares, Camilo, Di Giulio, Margarita, Salazar-Bookaman, Gabriella, Wojewodka, Danuta, Radzioch   +8 more
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Human and murine Th17

Current Opinion in HIV and AIDS, 2010
The purpose of this review is to summarize the most recent discoveries in the field of phenotypic and functional characterization of human and murine Th17 cells.Human Th17 cells express CD161 and exclusively originate from CD161 precursors present in umbilical cord blood and newborn thymus in response to the combined activity of IL-1beta and IL-23.
ANNUNZIATO, FRANCESCO, COSMI, LORENZO, ROMAGNANI, SERGIO   +2 more
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Th17 cells in inflammation

International Immunopharmacology, 2011
Naïve T cells are multipotential precursors that differentiate into various effector subsets, such as T helper type 1 (Th1) and Th2 cells, which are characterized by their distinct functions. The IL-17-producing T helper (Th17) cell has been recently identified as a new subset of the T helper cell and a mediator of inflammation associated with various ...
Akihiro, Kimura, Tadamitsu, Kishimoto
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Changes of Th17/Tc17 and Th17/Treg cells in endometrial carcinoma

Gynecologic Oncology, 2014
T helper 17 (Th17), T cytotoxic 17 (Tc17) and regulatory T (Treg) cells are important factors in the pathogenesis of inflammatory and autoimmune diseases. However, information concerning the roles of these cells in antitumor immunity or endometrial tumorigenesis remains limited.
Wenjing, Zhang, Fei, Hou, Yan, Zhang, Yongju, Tian, Jun, Jiao, Daoxin, Ma, Beihua, Kong, Baoxia, Cui   +7 more
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Inflammasome activation and Th17 responses

Molecular Immunology, 2019
Immune sensing of exogenous molecules from microbes (e.g., pathogen-associated molecular patterns) and nonmicrobial molecules (e.g., asbestos, alum, and silica), as well as endogenous damage-associated molecular patterns (e.g., ATP, uric acid crystals, and amyloid A) activates innate immunity by inducing immune-related genes, including proinflammatory ...
Jian Deng, Xiao-Qiang Yu, Pei-Hui Wang
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TH17 cells reach fever pitch

Nature Reviews Immunology, 2020
Febrile temperature increases the differentiation of T helper 17 (TH17) cells with a more pro-inflammatory, pathogenic phenotype, which could have implications for the pathogenesis of autoimmunity.
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