Results 21 to 30 of about 10,689,174 (395)
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. [PDF]
Journal of Experimental Medicine, 1995 Interleukin 12 (IL-12) initiates the differentiation of naive CD4+ T cells to T helper type 1 (Th1) cells critical for resistance to intracellular pathogens such as Leishmania major.
N.G. Jacobson +6 more
openalex +2 more sources
Annals of the New York Academy of Sciences, 2010 Autoreactive effector CD4+ T cells have been associated with the pathogenesis of autoimmune disorders. Early studies implicated the interferon (IFN)‐γ‐producing T helper (Th)1 subset of CD4+ cells as the causal agents in the pathogenesis of autoimmunity. However, further studies have suggested a more complex story. In models thought to be driven by Th1
Anna M. Hansen +2 more
openaire +3 more sources
IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.
Journal of Immunology, 1991 Murine IL-10 (cytokine synthesis inhibitory factor) inhibits cytokine production by Th1 cell clones when they are activated under conditions requiring the presence of APC. By preincubating APC with IL-10, we demonstrate that IL-10 acts principally on APC
D. Fiorentino +6 more
semanticscholar +1 more source
JIA patient T cells differentiate into Th1, Th17 and Th1.17 effector cells under Th1 polarizing conditions [PDF]
, 2021 AbstractObjectiveT helper cells develop into discrete Th1, Th2 or Th17 lineages that selectively express IFNγ, IL-4/IL-5/IL-13, or IL-17, respectively and actively silence signature cytokines expressed by opposing lineages. Our objective was to compare Th1, Th2 and Th17 polarization in cell culture models using JIA patient samples.MethodsPeripheral ...
Anna E. Patrick +8 more
openaire +2 more sources
Synthesis of C-5" and C-6"-modified α-GalCer analogues as iNKT-cell agonists [PDF]
, 2015 Alpha-Galactosyl Ceramide (α-GalCer) is a prototypical synthetic ligand of invariant natural killer T (iNKT) cells. Upon presentation by the MHC class I-like molecule CD1d, this glycolipid stimulates iNKT cells to secrete a vast amount of both pro ...
ASPESLAGH, SANDRINE +5 more
core +1 more source
PLoS Pathogens, 2022 Utilization of specialized Th1 cells to resist intracellular pathogenic infection represents an important innovation of adaptive immunity. Although transcriptional evidence indicates the potential presence of Th1-like cells in some fish species, the ...
Kete Ai +7 more
doaj +2 more sources
Imbalances in T Cell-Related Transcription Factors Among Patients with Hashimoto’s Thyroiditis
Sultan Qaboos University Medical Journal, 2017 Objectives: Imbalances in effector T cell functioning have been associated with a number of autoimmune diseases, including Hashimoto’s thyroiditis (HT).
Vahid Safdari +3 more
doaj +1 more source
Enhanced mechanical heterogeneity of cell collectives due to temporal fluctuations in cell elasticity [PDF]
Phys. Rev. E 107, 014401 (2023), 2022 Cells are dynamic systems characterized by temporal variations in biophysical properties such as stiffness and contractility. Recent studies show that the recruitment and release of actin filaments into and out of the cell cortex - a network of proteins underneath the cell membrane - leads to cell stiffening prior to division and softening immediately ...
arxiv +1 more source
Eomes controls the development of Th17‐derived (non‐classic) Th1 cells during chronic inflammation
European Journal of Immunology, 2018 It is well accepted that Th17 cells are a highly plastic cell subset that can be easily directed toward the Th1 phenotype in vitro and also in vivo during inflammation. However, there is an ongoing debate regarding the reverse plasticity (conversion from
A. Mazzoni +17 more
semanticscholar +1 more source
IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation
Scientific Reports, 2017 IL-10 is an immunomodulatory cytokine with a critical role in limiting inflammation in immune-mediated pathologies. The mechanisms leading to IL-10 expression by CD4+ T cells are being elucidated, with several cytokines implicated. We explored the effect
Ruth E. Mitchell +6 more
semanticscholar +1 more source