Results 21 to 30 of about 189,103 (261)

Th1 Differentiation Drives the Accumulation of Intravascular, Non-protective CD4 T Cells during Tuberculosis

Cell Reports, 2017
Recent data indicate that the differentiation state of Th1 cells determines their protective capacity against tuberculosis. Therefore, we examined the role of Th1-polarizing factors in the generation of protective and non-protective subsets of Mtb ...
Michelle A. Sallin, Shunsuke Sakai, Keith D. Kauffman, Howard A. Young, Jinfang Zhu, Daniel L. Barber   +5 more
doaj   +1 more source

CXCL10+ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter

Cell Reports, 2021
Summary: Correct positioning of T cells within infected tissues is critical for T cell activation and pathogen control. Upon tissue entry, effector T cells must efficiently locate antigen-presenting cells (APC) for peripheral activation.
Hen Prizant, Nilesh Patil, Seble Negatu, Noor Bala, Alexander McGurk, Scott A. Leddon, Angela Hughson, Tristan D. McRae, Yu-Rong Gao, Alexandra M. Livingstone, Joanna R. Groom, Andrew D. Luster, Deborah J. Fowell   +12 more
doaj   +1 more source

Imbalance of helper T cell type 1, helper T cell type 2 and associated cytokines in patients with systemic lupus erythematosus: A meta-analysis

Frontiers in Pharmacology, 2022
Objective: Th1 and Th2 cells and their associated cytokines function in the pathogenesis of systemic lupus erythematosus (SLE), but their exact roles are uncertain.
Shate Xiang, Jingjing Zhang, Mengge Zhang, Suhai Qian, Rongyun Wang, Yao Wang, Yingshi Xiang, Xinghong Ding   +7 more
doaj   +1 more source

Increased IFN-γ-producing Th17/Th1 cells and their association with lung function and current smoking status in patients with chronic obstructive pulmonary disease

BMC Pulmonary Medicine, 2019
Background Th17 cells are believed to be important proinflammatory cells in the pathogenesis of chronic obstructive pulmonary disease (COPD). Recent evidence demonstrates that Th17 cells display substantial developmental plasticity, giving rise to Th17 ...
Weihan Xu, Ruimin Li, Yongchang Sun
doaj   +1 more source

Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation

Frontiers in Immunology, 2020
Memory helper T (Th) cells are crucial for secondary immune responses against infectious microorganisms but also drive the pathogenesis of chronic inflammatory diseases.
Akane S. Suzuki, Ryoji Yagi, Motoko Y. Kimura, Chiaki Iwamura, Kenta Shinoda, Atsushi Onodera, Atsushi Onodera, Kiyoshi Hirahara, Damon J. Tumes, Damon J. Tumes, Ryo Koyama-Nasu, Siiri E. Iismaa, Robert M. Graham, Shinichiro Motohashi, Toshinori Nakayama   +14 more
doaj   +1 more source

Fludarabine Ameliorates Lupus Nephritis by Inhibiting T Cell Infiltration through STAT1 in R848-induced Mice Models

Korean Journal of Clinical Laboratory Science
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease caused by both genetic and environmental factors. Fludarabine is a selective inhibitor of signal transducer and activator of transcription 1 (STAT1). Recently, STAT1 inhibitors have been
Se Gwang JANG
doaj   +1 more source

Functional characteristics of Th1, Th17, and ex-Th17 cells in EAE revealed by intravital two-photon microscopy

Journal of Neuroinflammation, 2020
Background T helper (Th) 17 cells are a highly plastic subset of T cells, which in the context of neuroinflammation, are able to acquire pathogenic features originally attributed to Th1 cells (resulting in so called ex-Th17 cells).
Julia Loos, Samantha Schmaul, Theresa Marie Noll, Magdalena Paterka, Miriam Schillner, Julian T. Löffel, Frauke Zipp, Stefan Bittner   +7 more
doaj   +1 more source

Delayed Activation Kinetics of Th2- and Th17 Cells Compared to Th1 Cells

Cells, 2017
During immune responses, different classes of T cells arise: Th1, Th2, and Th17. Mobilizing the right class plays a critical role in successful host defense and therefore defining the ratios of Th1/Th2/Th17 cells within the antigen-specific T cell ...
Andrea Duechting, Anna Przybyla, Stefanie Kuerten, Paul V. Lehmann   +3 more
doaj   +1 more source

Interferon-β suppresses murine Th1 cell function in the absence of antigen-presenting cells. [PDF]

PLoS ONE, 2015
Interferon (IFN)-β is a front-line therapy for the treatment of the relapsing-remitting form of multiple sclerosis. However, its immunosuppressive mechanism of function remains incompletely understood. While it has been proposed that IFN-β suppresses the
Nicolas Boivin, Joanie Baillargeon, Prenitha Mercy Ignatius Arokia Doss, Andrée-Pascale Roy, Manu Rangachari   +4 more
doaj   +1 more source

Neuroantigen-Specific CD4 Cells Expressing Interferon-γ (IFN-γ), Interleukin (IL)-2 and IL-3 in a Mutually Exclusive Manner Prevail in Experimental Allergic Encephalomyelitis (EAE)

Cells, 2012
Experimental allergic encephalomyelitis (EAE) is mediated by neuroantigen-specific pro-inflammatory T cells of the Th1 and Th17 effector class. Th-17 cells can be clearly defined by expression of IL-17, but not IFN-γ, IL-2 or IL-3.
Paul V. Lehmann, Maike D. Hesse, Stefan Quast, Alexey Y. Karulin   +3 more
doaj   +1 more source