Results 31 to 40 of about 10,536,334 (332)

Pertussis infection and vaccination induces Th1 cells [PDF]

Immunology Today, 1998
In the recent Viewpoint article, Rook and Stanford[1xRook, G.A.W. and Stanford, J.L. Immunol. Today. 1998; 19: 113–116Abstract | Full Text PDF | PubMed | Scopus (0)See all References][1]suggest that increased incidence of allergies can be explained by decreased exposure to T helper 1 (Th1)-inducing pathogens and increased exposure to Th2-inducing ...
Brady, Miriam T., Mahon, Bernard P., Mills, Kingston H.G.   +2 more
openaire   +5 more sources

Th1 and Th2 Cells Help CD8 T-Cell Responses [PDF]

Infection and Immunity, 2007
ABSTRACTHelp from CD4 T cells is often important for the establishment of primary and memory CD8 T-cell responses. However, it has yet to be determined whether T helper polarization affects the delivery of help and/or whether responding CD8 T cells helped by Th1 or Th2 cells express distinct effector properties. To address these issues, we compared CD8
Erika L. Pearce, Hao Shen, Edward J. Pearce, Amy E. Troy, Melinda J. Ekkens, Devon J. Shedlock, Euihye Jung   +6 more
openaire   +3 more sources

Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis.

PLoS ONE, 2010
BackgroundThere is consensus that experimental autoimmune encephalomyelitis (EAE) can be mediated by myelin specific T cells of Th1 as well as of Th17 phenotype, but the contribution of either subset to the pathogenic process has remained controversial ...
Helena S Domingues, Marsilius Mues, Hans Lassmann, Hartmut Wekerle, Gurumoorthy Krishnamoorthy   +4 more
doaj   +1 more source

Imbalance of helper T cell type 1, helper T cell type 2 and associated cytokines in patients with systemic lupus erythematosus: A meta-analysis

Frontiers in Pharmacology, 2022
Objective: Th1 and Th2 cells and their associated cytokines function in the pathogenesis of systemic lupus erythematosus (SLE), but their exact roles are uncertain.
Shate Xiang, Jingjing Zhang, Mengge Zhang, Suhai Qian, Rongyun Wang, Yao Wang, Yingshi Xiang, Xinghong Ding   +7 more
doaj   +1 more source

Increased IFN-γ-producing Th17/Th1 cells and their association with lung function and current smoking status in patients with chronic obstructive pulmonary disease

BMC Pulmonary Medicine, 2019
Background Th17 cells are believed to be important proinflammatory cells in the pathogenesis of chronic obstructive pulmonary disease (COPD). Recent evidence demonstrates that Th17 cells display substantial developmental plasticity, giving rise to Th17 ...
Weihan Xu, Ruimin Li, Yongchang Sun
doaj   +1 more source

Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation

Frontiers in Immunology, 2020
Memory helper T (Th) cells are crucial for secondary immune responses against infectious microorganisms but also drive the pathogenesis of chronic inflammatory diseases.
Akane S. Suzuki, Ryoji Yagi, Motoko Y. Kimura, Chiaki Iwamura, Kenta Shinoda, Atsushi Onodera, Atsushi Onodera, Kiyoshi Hirahara, Damon J. Tumes, Damon J. Tumes, Ryo Koyama-Nasu, Siiri E. Iismaa, Robert M. Graham, Shinichiro Motohashi, Toshinori Nakayama   +14 more
doaj   +1 more source

Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells

Oncoimmunology, 2015
The role of inflammation in cancer is controversial as both tumor-promoting and tumor-suppressive aspects of inflammation have been reported. In particular, it has been shown that pro-inflammatory cytokines, like interleukin-1α (IL-1α), IL-1β, IL-6, and ...
O. Haabeth, K. B. Lorvik, H. Yagita, B. Bogen, A. Corthay   +4 more
semanticscholar   +1 more source

Elevated Ratio of Th17 Cell-Derived Th1 Cells (CD161+Th1 Cells) to CD161+Th17 Cells in Peripheral Blood of Early-Onset Rheumatoid Arthritis Patients

BioMed Research International, 2016
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the destruction of articular cartilage and bone with elevated levels of proinflammatory cytokines.
S. Kotake, Y. Nanke, T. Yago, M. Kawamoto, T. Kobashigawa, H. Yamanaka   +5 more
semanticscholar   +1 more source

Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17 [PDF]

Journal of Leukocyte Biology, 2007
AbstractRecent evidence fromseveral groups indicates that IL-17-producing Th17 cells, rather than, as once was thought, IFN-γ-producing Th1 cells, can represent the key effector cells in the induction/development of several autoimmune and allergic disorders.
Susumu Nakae, Yoichiro Iwakura, Hajime Suto, Hajime Suto, Stephen J. Galli   +4 more
openaire   +3 more sources

Fludarabine Ameliorates Lupus Nephritis by Inhibiting T Cell Infiltration through STAT1 in R848-induced Mice Models

Korean Journal of Clinical Laboratory Science
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease caused by both genetic and environmental factors. Fludarabine is a selective inhibitor of signal transducer and activator of transcription 1 (STAT1). Recently, STAT1 inhibitors have been
Se Gwang JANG
doaj   +1 more source