Results 51 to 60 of about 10,822,632 (330)

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

CD28-Dependent CTLA-4 Expression Fine-Tunes the Activation of Human Th17 Cells

iScience, 2020
Summary: Previous work has demonstrated that Th17 memory cells but not Th1 cells are resistant to CD28/CTLA-4 blockade with CTLA-4 Ig, leading us to investigate the individual roles of the CD28 and CTLA-4 cosignaling pathways on Th1 versus Th17 cells. We
Scott M. Krummey, Christina R. Hartigan, Danya Liu, Mandy L. Ford   +3 more
doaj   +1 more source

Circulating Th17, Th22, and Th1 Cells Are Elevated in the Guillain-Barré Syndrome and Downregulated by IVIg Treatments

Mediators of Inflammation, 2014
The Guillain-Barré syndrome (GBS) is considered a T helper 1 (Th1) cells-mediated acute inflammatory peripheral neuropathy. However, some changes in GBS could not be explained completely by Th1 cells pathogenic role.
Shujuan Li, T. Jin, Hong-Liang Zhang, Hong-gang Yu, Fan Meng, H. Concha Quezada, Jie Zhu   +6 more
semanticscholar   +1 more source

Pertussis infection and vaccination induces Th1 cells [PDF]

Immunology Today, 1998
In the recent Viewpoint article, Rook and Stanford[1xRook, G.A.W. and Stanford, J.L. Immunol. Today. 1998; 19: 113–116Abstract | Full Text PDF | PubMed | Scopus (0)See all References][1]suggest that increased incidence of allergies can be explained by decreased exposure to T helper 1 (Th1)-inducing pathogens and increased exposure to Th2-inducing ...
Brady, Miriam T., Mahon, Bernard P., Mills, Kingston H.G.   +2 more
openaire   +3 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Dose-dependent induction of murine Th1/Th2 responses to sheep red blood cells occurs in two steps: antigen presentation during second encounter is decisive.

PLoS ONE, 2013
The differentiation of CD4 T cells into Th1 and Th2 cells in vivo is difficult to analyze since it is influenced by many factors such as genetic background of the mice, nature of antigen, and adjuvant.
Claudia Stamm, Julia Barthelmann, Natalia Kunz, Kai-Michael Toellner, Jürgen Westermann, Kathrin Kalies   +5 more
doaj   +1 more source

Supplementary Table 1 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8⁺ T Cells [PDF]

, 2023
Jérémy Goc, Claire Germain, Thi Kim Duy Vo-Bourgais, Audrey Lupo, Christophe Klein, Samantha Knockaert, Luc de Chaisemartin, Hanane Ouakrim, Étienne Becht, Marco Alifano, Pierre Validire, Romain Remark, Scott A. Hammond, Isabelle Cremer, Diane Damotte, Wolf H. Fridman, Catherine Sautès‐Fridman, Marie‐Caroline Dieu‐Nosjean   +17 more
openalex   +1 more source

Th1 and Th17 Cells Induce Proliferative Glomerulonephritis [PDF]

Journal of the American Society of Nephrology, 2009
Th1 effector CD4+ cells contribute to the pathogenesis of proliferative and crescentic glomerulonephritis, but whether effector Th17 cells also contribute is unknown. We compared the involvement of Th1 and Th17 cells in a mouse model of antigen-specific glomerulonephritis in which effector CD4+ cells are the only components of adaptive immunity that ...
Shaun A, Summers, Oliver M, Steinmetz, Ming, Li, Joshua Y, Kausman, Timothy, Semple, Kristy L, Edgtton, Dorin-Bogdan, Borza, Hal, Braley, Stephen R, Holdsworth, A Richard, Kitching   +9 more
openaire   +2 more sources

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

MicroRNA-451a and Th1/Th2 ratio inform inflammation, septic organ injury, and mortality risk in sepsis patients

Frontiers in Microbiology, 2022
AimsMicroRNA-451a (miR-451a) regulates Th1/Th2 cell differentiation, inflammation, and septic organ injury in several experiments. Therefore, the present study aimed to explore the inter-correlation of miR-451a with the Th1/Th2 ratio, and their ...
Feng Geng, Wei Liu, Li Yu
doaj   +1 more source