Results 61 to 70 of about 10,689,174 (395)

CXCR3-Expressing T Cells in Infections and Autoimmunity

Frontiers in Bioscience-Landmark
The chemokine receptor CXCR3 and its ligands (MIG/CXCL9, IP-10/CXCL10, and I-TAC/CXCL11) play a central role in the generation of cellular inflammation, both in the protective responses to invading pathogens, and in different pathological conditions ...
Artem Rubinstein, Igor Kudryavtsev, Natalia Arsentieva, Zoia R. Korobova, Dmitry Isakov, Areg A. Totolian   +5 more
doaj   +1 more source

Adoptive T-cell therapy with hexon-specific Th1 cells as a treatment of refractory adenovirus infection after HSCT.

Blood, 2015
Hematopoietic stem cell transplantation (HSCT) has improved over the last few decades. However, viral infections are often refractory to pharmacologic treatment and require alternative treatment strategies such as immunotherapy.
J. Feucht, K. Opherk, P. Lang, S. Kayser, L. Hartl, W. Bethge, S. Matthes‐Martin, P. Bader, M. Albert, B. Maecker-Kolhoff, J. Greil, H. Einsele, P. Schlegel, F. Schuster, B. Kremens, C. Rossig, B. Gruhn, R. Handgretinger, T. Feuchtinger   +18 more
semanticscholar   +1 more source

A cell membrane model that reproduces cortical flow-driven cell migration and collective movement [PDF]

, 2023
Many fundamental biological processes are dependent on cellular migration. Although the mechanical mechanisms of single-cell migration are relatively well understood, those underlying migration of multiple cells adhered to each other in a cluster, referred to as cluster migration, are poorly understood.
arxiv   +1 more source

Neuroantigen-Specific CD4 Cells Expressing Interferon-γ (IFN-γ), Interleukin (IL)-2 and IL-3 in a Mutually Exclusive Manner Prevail in Experimental Allergic Encephalomyelitis (EAE)

Cells, 2012
Experimental allergic encephalomyelitis (EAE) is mediated by neuroantigen-specific pro-inflammatory T cells of the Th1 and Th17 effector class. Th-17 cells can be clearly defined by expression of IL-17, but not IFN-γ, IL-2 or IL-3.
Paul V. Lehmann, Maike D. Hesse, Stefan Quast, Alexey Y. Karulin   +3 more
doaj   +1 more source

Functional characteristics of Th1, Th17, and ex-Th17 cells in EAE revealed by intravital two-photon microscopy

Journal of Neuroinflammation, 2020
Background T helper (Th) 17 cells are a highly plastic subset of T cells, which in the context of neuroinflammation, are able to acquire pathogenic features originally attributed to Th1 cells (resulting in so called ex-Th17 cells).
Julia Loos, Samantha Schmaul, Theresa Marie Noll, Magdalena Paterka, Miriam Schillner, Julian T. Löffel, Frauke Zipp, Stefan Bittner   +7 more
doaj   +1 more source

Resting respiratory tract dendritic cells preferentially stimulate T helper cell Type 2(Th2) responses and require obligatory cytokine signals for induction of Th1 immunity [PDF]

, 1998
Consistent with their role in host defense, mature dendritic cells (DCs) from central lymphoid organs preferentially prime for T helper cell type 1 (Th1)-polarized immunity.
Holt, P.G., Lee, P.T., Pimm, C.L., Proksch, S., Stumbles, P.A., Thomas, J.A., Venaille, T.J.   +6 more
core   +2 more sources

Interferon-β suppresses murine Th1 cell function in the absence of antigen-presenting cells. [PDF]

PLoS ONE, 2015
Interferon (IFN)-β is a front-line therapy for the treatment of the relapsing-remitting form of multiple sclerosis. However, its immunosuppressive mechanism of function remains incompletely understood. While it has been proposed that IFN-β suppresses the
Nicolas Boivin, Joanie Baillargeon, Prenitha Mercy Ignatius Arokia Doss, Andrée-Pascale Roy, Manu Rangachari   +4 more
doaj   +1 more source

GADD45γ Mediates the Activation of the p38 and JNK MAP Kinase Pathways and Cytokine Production in Effector TH1 Cells [PDF]

, 2001
The p38 and JNK stress-activated MAPK signal transduction pathways are activated by T cell receptor (TCR) signaling and are required for IFN-γ production by TH1 effector cells.
Chow, Chi-wing, Davis, Roger J, Flavell, Richard A, Li, Baiyong, Lu, Binfeng, Yu, Hong, Zheng, Wei-ping   +6 more
core   +1 more source

Intratumoral natural killer cells show reduced effector and cytolytic properties and control the differentiation of effector Th1 cells

Oncoimmunology, 2016
Natural killer (NK) cells are known to have effector and cytolytic properties to kill virus infected or tumor cells spontaneously. Due to these properties, NK cells have been used as an adoptive cellular therapy to control tumor growth in various ...
S. Paul, Neeraja Kulkarni,  . Shilpi, G. Lal   +3 more
semanticscholar   +1 more source

Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis. [PDF]

, 2015
BackgroundIn multiple sclerosis (MS) and its widely used animal model, experimental autoimmune encephalomyelitis (EAE), autoreactive T cells contribute importantly to central nervous system (CNS) tissue damage and disease progression. Promoting apoptosis
Chen, Yingyu, Deng, Wenbin, Liu, Wenwei, Xiao, Juan   +3 more
core   +2 more sources