Results 211 to 220 of about 22,410 (257)
Boost of Chiroptical Responses through the Enhancement of Electron Transition Dipole Moment
Chemistry – A European Journal, Accepted Article.The development of robust chiroptical systems is crucial for advancing optoelectronic technologies. Spirobifluorenes (SBFs) have proven to be versatile scaffolds for the construction of a wide variety of robust axially chiral compounds presenting strong chiroptical responses.
Iván Gómez-Oya +4 more
wiley +1 more source
ChemMedChem, Volume 20, Issue 6, March 15, 2025.This review goes beyond the famous MD‐2/TLR4‐mediated recognition of LPS, pointing the attention on other immune detection systems and their impact on human physiology and pathology. Understanding these additional pathways is key for the development of pharmacologically active molecules to modulate the immune response and to conceive new strategies to ...
Stefania De Chiara +7 more
wiley +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract RBN‐3143 is an inhibitor of PARP14 in development for inflammatory diseases. Multiple assessments were conducted to evaluate the clinical pharmacology properties of RBN‐3134. A randomized, double‐blind, placebo‐controlled study assigned healthy volunteers (HVs) to single ascending doses (SADs) (25‐1000 mg) or multiple ascending doses (MADs ...
Thomas M. Polasek +9 more
wiley +1 more source
ENERGY &ENVIRONMENTAL MATERIALS, Volume 8, Issue 3, May 2025.Recycling polyvinyl chloride (PVC) waste into triboelectric nanogenerators (TENGs) offers a sustainable method for energy harvesting, self‐powered sensing, and environmental remediation through enhanced nanofiber design and piezoelectric performance. Recycling plastic waste into triboelectric nanogenerators (TENGs) presents a sustainable approach to ...
Shabnam Yavari +5 more
wiley +1 more source
Biomarkers of lung congestion and injury in acute heart failure
ESC Heart Failure, Volume 12, Issue 2, Page 781-789, April 2025.Abstract Acute heart failure (AHF) classification and management are primarily based on lung congestion and/or hypoperfusion. The quantification of the vascular and tissue lung damage is not standard practice though biomarkers of lung injury may play a relevant role in this context.
Marco Guazzi +9 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler +4 more
wiley +1 more source
ESC Heart Failure, EarlyView.Abstract Right ventricular failure (RVF) is a common complication following left ventricular assist device (LVAD) implantation and increases patient morbidity and mortality. Due to the complex and limited understanding of RVF pathophysiology, efforts to prognosticate RVF after LVAD have been challenging.
Abdul‐Fatawu Osman +11 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 3, Page 2077-2086, June 2025.Abstract Aims The inflammatory profile of cardiogenic shock (CS) after myocardial infarction affects outcomes; however, little is known about the impact of inflammatory changes in CS caused by acute decompensated heart failure (ADHF‐CS). We measured levels of inflammatory cytokines in patients with ADHF‐CS admitted to a cardiac intensive care unit ...
Darshan H. Brahmbhatt +9 more
wiley +1 more source
Immune cell dynamics in heart failure: implicated mechanisms and therapeutic targets
ESC Heart Failure, Volume 12, Issue 3, Page 1739-1758, June 2025.Abstract The relationship between heart failure (HF) and immune activation has garnered significant interest. Studies highlight the critical role of inflammation in HF, affecting cardiac structure and function. Despite promising anti‐inflammatory therapies, clinical trials have faced challenges, indicating an incomplete understanding of immune ...
Gen Li, Wu He, Dao Wen Wang
wiley +1 more source
Earthquake Engineering &Structural Dynamics, Volume 54, Issue 8, Page 2084-2105, 10 July 2025.ABSTRACT This article presents the Multi‐Axial Subassemblage Testing facility of ETH Zurich, Switzerland (ETHZ‐MAST) for quasi‐static testing and hybrid simulation (HS) of large‐scale structural components and assemblies. The ETHZ‐MAST features a 6‐degrees‐of‐freedom (DOFs, 3 translations and 3 rotations) loading system based on a steel crosshead and ...
Diego Pizarro +3 more
wiley +1 more source