Results 21 to 30 of about 22,410 (257)
Innate immune system and preeclampsia
Frontiers in Immunology, 2014 Normal pregnancy is considered as a Th2 type immunological state that favors an immune-tolerance environment in order to prevent fetal rejection.
Alejandra ePerez-Sepulveda +3 more
doaj +1 more source
IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. [PDF]
The Journal of Immunology, 2007 AbstractIL-27 up-regulates Th1 but down-regulates Th2 responses. However, its molecular mechanism and regulatory effects on polarized Th2 cells remain unclear. In this study, we have revealed that IL-27 inhibits Th2 cell development as well as Th2 cytokines production from already polarized Th2 cells by down-regulation of GATA-3 and up-regulation of T ...
Junichiro Mizuguchi +4 more
openaire +3 more sources
Genetic analysis of differentiation of T-helper lymphocytes [PDF]
Genetics and Molecular Research 2 (2012) 972-987, 2013 In the human immune system, T-helper cells are able to differentiate into two lymphocyte subsets: Th1 and Th2. The intracellular signaling pathways of differentiation form a dynamic regulation network by secreting distinctive types of cytokines, while differentiation is regulated by two major gene loci: T-bet and GATA-3.
arxiv +1 more source
Role of IL-25 in Immunity [PDF]
Journal of Clinical and Diagnostic Research, 2015 IL-25 a 2o KDa protein mostly known as IL-17E, encoded by chromosome 14, and containing 117 amino acids. Cytokine IL-17 family consists of 6 members; IL-17A to IL-17F, among which IL-25 has a unique structure and function. The receptor of IL-25 (IL-17BR)
Azar Valizadeh +3 more
doaj +1 more source
Hypericum perforatum Alleviates Ovalbumin-Induced Asthma through Downregulating TH2 and Upregulating TH1 Related Parameters in BALB/C Mice [PDF]
Pharmaceutical SciencesBackground: Allergic asthma is a chronic and inflammatory disease of the respiratory tract, which is characterized by inflammation, airway obstruction and swelling. Anti-inflammatory compounds can be used to improve the disease severity.
Fahimeh Rostamabadi +3 more
doaj +1 more source
Beyond CCR7: dendritic cell migration in type 2 inflammation
Frontiers in ImmunologyConventional dendritic cells (cDCs) are crucial antigen-presenting cells that initiate and regulate T cell responses, thereby shaping immunity against pathogens, innocuous antigens, tumors, and self-antigens. The migration of cDCs from peripheral tissues
Audrey Meloun +2 more
doaj +1 more source
Pollinosis in children and adolescents: modern aspects of pathogenesis and tendencies in therapy
Аллергология и Иммунология в Педиатрии, 2023 The development of pollinosis in children and adolescents is determined by the influence of genetic and environmental factors. The pathogenetic basis of pollinosis in children and adolescents is the differentiation of Th0 to Th2, activation of Th2cells ...
I. I. Balabolkin
doaj +1 more source
Th2 Cytokines and Atopic Dermatitis [PDF]
Journal of Clinical & Cellular Immunology, 2011 Atopic dermatitis (AD), a chronic relapsing inflammatory skin disease, is increasing in prevalence around the world. Intensive research is ongoing to understand the mechanisms involved in the development of AD and offer new treatment options for patients suffering from AD.
Umasundari Sivaprasad, Eric B. Brandt
openaire +3 more sources
Th1/Th2 differentiation and B cell function by the atypical PKCs and their regulators
Frontiers in Immunology, 2012 The members of the atypical PKCs (aPKC) kinase subfamily, PKCζ and PKCλ/ι, as well as their adapters, p62 and Par-6, form part of the PB1-domain-containing group of signaling regulators.
Pilar eMartin, Jorge eMoscat
doaj +1 more source
The Stellar Kinematic Center and the True Galactic Nucleus of NGC253 [PDF]
, 2010 We present the first sub-arcsecond resolution two-dimensional stellar kinematics and X-ray observations of the prototypical starburst galaxy NGC253 which define the position and nature of the galactic nucleus. We get an estimate of the stellar kinematic center location corresponding to an area of r~1.2" centered 0.7" southwest from the radio core (TH2).
arxiv +1 more source