Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis [PDF]
Frontiers in Immunology, 2022 Type 2 helper T (Th2) cells, a subset of CD4+ T cells, play an important role in the host defense against pathogens and allergens by producing Th2 cytokines, such as interleukin-4 (IL-4), IL-5, and IL-13, to trigger inflammatory responses.
Kota Kokubo +7 more
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Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling. [PDF]
PLoS ONE, 2021 Histamine, which is mainly produced by mast cells and basophils, participates in various allergic symptoms, and some studies have reported that macrophages also produce histamine.
Naruhito Iwasaki +6 more
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Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 Infections by the soil-transmitted threadworm Strongyloides stercoralis affect 30–100 million people worldwide, predominantly in tropic and sub-tropic regions. Here we assessed the T helper cell phenotypes in threadworm-infected patients and experimental
Cristin N. Bock +12 more
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Crosstalk between ILC2s and Th2 cells varies among mouse models [PDF]
Cell Reports, 2023 Summary: Type 2 T helper (Th2) cells and group 2 innate lymphoid cells (ILC2s) provide protection against helminth infection and are involved in allergic responses. However, their relative importance and crosstalk during type 2 immune responses are still
Rama K. Gurram +14 more
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SERPINB10 contributes to asthma by inhibiting the apoptosis of allergenic Th2 cells [PDF]
Respiratory Research, 2021 Background Serine peptidase inhibitor, clade B, member 10 (SERPINB10) contributes to allergic inflammation in asthma. However, its role in the T-helper type 2 (Th2) response of allergic asthma is not known.
Yuqing Mo +8 more
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Distinct functions of tissue-resident and circulating memory Th2 cells in allergic airway disease. [PDF]
J Exp Med, 2020 Memory CD4+ T helper type 2 (Th2) cells are critical in driving allergic asthma pathogenesis, yet the mechanisms whereby tissue-resident memory Th2 cells (Th2 Trm) and circulating memory Th2 cells collaborate in vivo remain unclear.
Rahimi RA +4 more
europepmc +2 more sources
Differentiation and Regulation of Bovine Th2 Cells In Vitro [PDF]
CellsBovine Th2 cells have usually been characterized by IL4 mRNA expression, but it is unclear whether their IL4 protein expression corresponds to transcription.
Anmol Kandel +4 more
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Pathogenic Effector Th2 Cells in Allergic Eosinophilic Inflammatory Disease
Frontiers in Medicine, 2017 There is an absolute requirement for Th2 cells in the pathogenesis of allergen-driven eosinophil-rich type 2 inflammation. Although Th2 cells are generally regarded as a homogeneous population, in the past decade there has been increasing evidence for a ...
Alyssa Mitson-Salazar, Calman Prussin
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IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells. [PDF]
PLoS Pathogens, 2015 Parasitic helminths establish chronic infections in mammalian hosts. Helminth/Plasmodium co-infections occur frequently in endemic areas. However, it is unclear whether Plasmodium infections compromise anti-helminth immunity, contributing to the ...
Stephanie M Coomes +11 more
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Helminth-induced Th2 cell dysfunction is distinct from exhaustion and is maintained in the absence of antigen. [PDF]
PLoS Neglected Tropical Diseases, 2019 T cell-intrinsic regulation, such as anergy, adaptive tolerance and exhaustion, is central to immune regulation. In contrast to Type 1 and Type 17 settings, knowledge of the intrinsic fate and function of Th2 cells in chronic Type 2 immune responses is ...
Johanna A Knipper +2 more
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