Crosstalk between ILC2s and Th2 cells varies among mouse models [PDF]
Cell Reports, 2023 Summary: Type 2 T helper (Th2) cells and group 2 innate lymphoid cells (ILC2s) provide protection against helminth infection and are involved in allergic responses. However, their relative importance and crosstalk during type 2 immune responses are still
Rama K. Gurram +14 more
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Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis [PDF]
Frontiers in Immunology, 2022 Type 2 helper T (Th2) cells, a subset of CD4+ T cells, play an important role in the host defense against pathogens and allergens by producing Th2 cytokines, such as interleukin-4 (IL-4), IL-5, and IL-13, to trigger inflammatory responses.
Kota Kokubo +7 more
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SERPINB10 contributes to asthma by inhibiting the apoptosis of allergenic Th2 cells [PDF]
Respiratory Research, 2021 Background Serine peptidase inhibitor, clade B, member 10 (SERPINB10) contributes to allergic inflammation in asthma. However, its role in the T-helper type 2 (Th2) response of allergic asthma is not known.
Yuqing Mo +8 more
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Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling. [PDF]
PLoS ONE, 2021 Histamine, which is mainly produced by mast cells and basophils, participates in various allergic symptoms, and some studies have reported that macrophages also produce histamine.
Naruhito Iwasaki +6 more
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Differentiation and Regulation of Bovine Th2 Cells In Vitro [PDF]
CellsBovine Th2 cells have usually been characterized by IL4 mRNA expression, but it is unclear whether their IL4 protein expression corresponds to transcription.
Anmol Kandel +4 more
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Microbial antigens-loaded myeloma cells enhance Th2 cell proliferation and myeloma clonogenicity via Th2–myeloma cell interaction [PDF]
BMC Cancer, 2019 Background Myeloma cells retain B cell functions, considered to be potential antigen presenting cells, yet there is little information regarding promoting Th2 cell proliferation or the direct effects to myeloma on the Th2 cells stimulated by microbial ...
Faqing Tian +8 more
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New Insights into HIV Life Cycle, Th1/Th2 Shift during HIV Infection and Preferential Virus Infection of Th2 Cells: Implications of Early HIV Treatment Initiation and Care [PDF]
LifeThe theory of immune regulation involves a homeostatic balance between T-helper 1 (Th1) and T-helper 2 (Th2) responses. The Th1 and Th2 theories were introduced in 1986 as a result of studies in mice, whereby T-helper cell subsets were found to direct ...
Joseph Hokello +6 more
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The Metabolic Requirements of Th2 Cell Differentiation [PDF]
Frontiers in Immunology, 2019 Upon activation, naïve CD4+ T cells differentiate into a number of specialized T helper (Th) cell subsets. Th2 cells are central players in immunity to helminths and are implicated in mediating the inflammatory pathology associated with allergies.
Julian M. Stark +2 more
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PGI2 signaling metabolically reprograms CD4 Th2 cells and represses allergic airway inflammation. [PDF]
J ImmunolZhou W +10 more
europepmc +3 more sources
Interleukin-33/ST2: A new signaling pathway in immunity and immunopathology [PDF]
Vojnosanitetski Pregled, 2012 nema
Pavlović Slađana +5 more
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