Crosstalk between ILC2s and Th2 cells varies among mouse models. [PDF]
Cell Rep, 2023 Summary: Type 2 T helper (Th2) cells and group 2 innate lymphoid cells (ILC2s) provide protection against helminth infection and are involved in allergic responses. However, their relative importance and crosstalk during type 2 immune responses are still
Gurram RK +14 more
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Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis. [PDF]
Front Immunol, 2022 Type 2 helper T (Th2) cells, a subset of CD4+ T cells, play an important role in the host defense against pathogens and allergens by producing Th2 cytokines, such as interleukin-4 (IL-4), IL-5, and IL-13, to trigger inflammatory responses.
Kokubo K +5 more
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Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling. [PDF]
PLoS One, 2021 Histamine, which is mainly produced by mast cells and basophils, participates in various allergic symptoms, and some studies have reported that macrophages also produce histamine.
Iwasaki N +6 more
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Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils. [PDF]
Br J Cancer, 2023 Background Immunotherapy of gastrointestinal cancers is challenging; however, several lines of evidence suggest that adoptive transfer of stimulated or modified immune cells support not only protective role of immune cells in tumor microenvironment, but ...
Jacenik D, Karagiannidis I, Beswick EJ.
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SERPINB10 contributes to asthma by inhibiting the apoptosis of allergenic Th2 cells. [PDF]
Respir Res, 2021 Background Serine peptidase inhibitor, clade B, member 10 (SERPINB10) contributes to allergic inflammation in asthma. However, its role in the T-helper type 2 (Th2) response of allergic asthma is not known.
Mo Y +8 more
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Pathogenic Effector Th2 Cells in Allergic Eosinophilic Inflammatory Disease
Frontiers in Medicine, 2017 There is an absolute requirement for Th2 cells in the pathogenesis of allergen-driven eosinophil-rich type 2 inflammation. Although Th2 cells are generally regarded as a homogeneous population, in the past decade there has been increasing evidence for a ...
Alyssa Mitson-Salazar, Calman Prussin
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Differentiation and Regulation of Bovine Th2 Cells In Vitro. [PDF]
CellsBovine Th2 cells have usually been characterized by IL4 mRNA expression, but it is unclear whether their IL4 protein expression corresponds to transcription.
Kandel A, Li L, Wang Y, Tuo W, Xiao Z.
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Microbial antigens-loaded myeloma cells enhance Th2 cell proliferation and myeloma clonogenicity via Th2–myeloma cell interaction [PDF]
BMC Cancer, 2019 Background Myeloma cells retain B cell functions, considered to be potential antigen presenting cells, yet there is little information regarding promoting Th2 cell proliferation or the direct effects to myeloma on the Th2 cells stimulated by microbial ...
Faqing Tian +8 more
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T follicular helper and TH2 cells in allergic responses
Allergology International, 2017 IL-4 is a cytokine commonly secreted by TH2 and follicular helper T (TFH) cells after antigenic sensitization. TH2 cells have been thought to be the major contributor of B cell help as a source of IL-4 responsible for class switch recombination to ...
Masato Kubo
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Inflammatory Bowel Diseases, 1999 A large body of evidence indicates the existence of functionally polarized CD4+ T-cell responses based on their profile of cytokine secretion. Type 1 T helper (Th1) cells produce interferon-gamma, interleukin (IL)-2, and tumour necrosis factor (TNF)-beta, which activate macrophages and are responsible for cell-mediated immunity and phagocyte-dependent ...
S. Romagnani
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