Results 41 to 50 of about 149,069 (251)

Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy

Acta Pharmaceutica Sinica B, 2021
Genomic instability remains an enabling feature of cancer and promotes malignant transformation. Alterations of DNA damage response (DDR) pathways allow genomic instability, generate neoantigens, upregulate the expression of programmed death ligand 1 (PD-
Minlin Jiang, Keyi Jia, Lei Wang, Wei Li, Bin Chen, Yu Liu, Hao Wang, Sha Zhao, Yayi He, Caicun Zhou   +9 more
doaj   +1 more source

Therapeutic opportunities within the DNA damage response [PDF]

, 2015
The DNA damage response (DDR) is essential for maintaining the genomic integrity of the cell, and its disruption is one of the hallmarks of cancer.
A Chatr-Aryamontri, A Franceschini, A Franchitto, A Gaulton, AA Larrea, AC Antoniou, AE Tomkinson, AJ Bardin, AK Rustgi, AL Chambers, AL Marston, Amanda C. Schierz, AP Eker, AW Oliver, B Vogelstein, B Vogelstein, Bissan Al-Lazikani, C Greenman, C McWhirter, CA Lipinski, CJ Lord, CJ Richardson, D Croft, D Dorjsuren, DM van Pel, DM van Pel, DP Cahill, DW Parsons, E Kuhn, E Pastwa, EB Fauman, EC Friedberg, EK Bancroft, Frances M. G. Pearl, FS Collins, GH Nguyen, GM Kupfer, GP Pfeifer, H Panda, J Bartkova, J Zhang, JL Riffell, JM Daley, JM Murray, JM Paul, JN Weinstein, JP Overington, JW Harper, K Chang, KC Bulusu, KH Khoo, KH Lim, KK Hoe, KL Kanchi, L Galluzzi, L Weiss, Laurence H. Pearl, LB Alexandrov, LB Alexandrov, LJ Barber, LV Liu, M Aggarwal, M Ashburner, M Bastian, M D'Antonio, M Kanehisa, M Tischkowitz, ME Smoot, MN Patel, MS Lindstrom, NC Turner, NG Howlett, NG Jaspers, NJ Curtin, O Espinosa, P Bouwman, P Workman, PA Futreal, PA Janne, PV Hornbeck, Q Liang, R Brough, R Brough, R Buisson, R Mehra, R Nishi, RA Burrell, RE Verdun, S Prakash, SA Forbes, SA Martin, SI Nikolaev, Simon E. Ward, SL Allinson, SP Jackson, T Helleday, TD Halazonetis, TR Mereniuk, V Landre, WG Kaelin Jr., X Jacq, Y Nakazawa, YH Fan, Z Wang   +103 more
core   +1 more source

Pathogenic variants in human DNA damage repair genes mostly arose after the latest human out-of-Africa migration

Frontiers in Genetics
IntroductionThe DNA damage repair (DDR) system in human genome is pivotal in maintaining genomic integrity. Pathogenic variation (PV) in DDR genes impairs their function, leading to genome instability and increased susceptibility to diseases, especially ...
Jun He, Si Hoi Kou, Jiaheng Li, Xiaofan Ding, San Ming Wang   +4 more
doaj   +1 more source

Inside the hypoxic tumour: reprogramming of the DDR and radioresistance [PDF]

Cell Death Discovery, 2020
AbstractThe hypoxic tumour is a chaotic landscape of struggle and adaption. Against the adversity of oxygen starvation, hypoxic cancer cells initiate a reprogramming of transcriptional activities, allowing for survival, metastasis and treatment failure. This makes hypoxia a crucial feature of aggressive tumours.
Begg, Katheryn, Tavassoli, Mahvash
openaire   +3 more sources

The Distance Duality Relation from Strong Gravitational Lensing

, 2016
Under very general assumptions of metric theory of spacetime, photons traveling along null geodesics and photon number conservation, two observable concepts of cosmic distance, i.e.
Biesiada, Marek, Cao, Shuo, Li, Zhengxiang, Liao, Kai, Zheng, Xiaogang, Zhu, Zong-Hong   +5 more
core   +1 more source

Genome-wide multi-parametric analysis of H2AX or γH2AX distributions during ionizing radiation-induced DNA damage response [PDF]

, 2013
Background: After induction of DNA double strand breaks (DSBs), the DNA damage response (DDR) is activated. One of the earliest events in DDR is the phosphorylation of serine 139 on the histone variant H2AX (gH2AX) catalyzed by phosphatidylinositol 3 ...
Cardoso, Maria Cristina, Durante, Marco, Natale, Francesco, Rapp, Alexander, Taucher-Scholz, Gisela, Yu, Wei   +5 more
core   +1 more source

Diverse immune response of DNA damage repair-deficient tumors

Cell Reports Medicine, 2021
Summary: Tumors with DNA damage repair (DDR) deficiency accumulate genomic alterations that may serve as neoantigens and increase sensitivity to immune checkpoint inhibitor.
Tao Qing, Tomi Jun, Katherine E. Lindblad, Amaia Lujambio, Michal Marczyk, Lajos Pusztai, Kuan-lin Huang   +6 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

DNA damage repair alterations modulate M2 polarization of microglia to remodel the tumor microenvironment via the p53-mediated MDK expression in gliomaResearch in context

EBioMedicine, 2019
Background: DNA damage repair (DDR) alterations are important events in cancer initiation, progression, and therapeutic resistance. However, the involvement of DDR alterations in glioma malignancy needs further investigation.
Xiangqi Meng, Chunbin Duan, Hengyuan Pang, Qun Chen, Bo Han, Caijun Zha, Magafurov Dinislam, Pengfei Wu, Ziwei Li, Shihong Zhao, Ruijia Wang, Lin Lin, Chuanlu Jiang, Jinquan Cai   +13 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source