Results 121 to 130 of about 53,058 (296)

Alterations in cancer cell metabolism : The Warburg effect and metabolic adaptation

, 2015
The Warburg effect means higher glucose uptake of cancer cells compared to normal tissues, whereas a smaller fraction of this glucose is employed for oxidative phosphorylation.
Salehzadeh-Yazdi, Ali, Masoudi-Nejad, Ali, Asgari, Yazdan, Zabihinpour, Zahra, Schreiber, Falk   +4 more
core   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

A kinetic description of the Warburg effect in CHO cells

, 2023
The Warburg effect has been known about for nearly 100 years. It is characterised by a high rate of glycolytic flux and production of lactate in highly proliferating cells, relative to their slower growing counterparts.
Cowie, Nicholas Luke
core  

PARP14 promotes the warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation [PDF]

, 2015
Most tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and evade apoptosis. Intriguingly, the molecular mechanisms that link the Warburg effect with the suppression of apoptosis are not well understood.
Fung, SW, Liu, Y, Chokshi, S, Chai, J-G, Bubici, C, Williams, R, Papa, S, D'Santos, C, Dyson, J, Del Rio, A, Iansante, V, Anders, RA, Choy, PM   +12 more
core   +1 more source

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

One‐Step, High‐Removal‐Rate and Low‐Damage Chemical Mechanical Polishing of InP Enabled by Hydrolysis Activated PF6− with In Situ Fluoride Passivation

Advanced Science, EarlyView.
In this work, we propose a CMP method for InP using NH4PF₆, which hydrolyzes under In3+ catalysis to form reactive species. These convert InP into low‐binding‐energy fluorides, facilitating removal and dissolution. The process delivers high material removal rates, smooth surfaces, and fluorine passivation that lowers defect density and improves ...
Shigong Fu, Jianwei Zhou, Chenwei Wang, Yanchao Ge, Chong Luo, Yuhang Qi   +5 more
wiley   +1 more source

Immunometabolism in Tuberculosis

Frontiers in Immunology, 2016
Immunometabolism, the study of the relationship between bioenergetic pathways and specific functions of immune cells, has recently gained increasing appreciation.
Lanbo eShi, Eliseo A Eugenin, Selvakumar eSubbian   +2 more
doaj   +1 more source

Predictive significance of glycolysis-associated lncRNA profiles in colorectal cancer progression

BMC Medical Genomics
Background The Warburg effect is a hallmark characteristic of colorectal cancer (CRC). Despite extensive research, the role of long non-coding RNAs (lncRNAs) in influencing the Warburg effect remains incompletely understood.
Rui Mao, Chenxin Xu, Quanzheng Zhang, Zheng Wang, Yanjun Liu, Yurui Peng, Ming Li   +6 more
doaj   +1 more source

Bipolar Covalent Organic Frameworks Crafting Core–Shell Heterostructured Cathode for High–Performance Lithium–Organic Batteries

Advanced Science, EarlyView.
A bipolar CNT@COF core–shell heterostructure cathode constructed via synergistic molecular and microstructural engineering enables rapid electron/ion transport and efficient utilization of electroactive groups for high–performance lithium–organic batteries. ABSTRACT Covalent organic frameworks (COFs) with tunable molecular structures and ordered porous
Yalong Jiang, Nan Jiang, Yu Dou, Zixuan Chen, Yunhai Zhu, Long Chen, Yingkui Yang   +6 more
wiley   +1 more source

A New Target for Hepatic Fibrosis Prevention and Treatment: The Warburg Effect

Frontiers in Bioscience-Landmark
Hepatic fibrosis is a major public health problem that endangers human wellbeing. In recent years, a number of studies have revealed the important impact of metabolic reprogramming on the occurrence and development of hepatic fibrosis.
Meng Pan, Huanyu Li, Xiaoyan Shi
doaj   +1 more source