Results 131 to 140 of about 133,879,868 (285)

Activation‐Induced Turbostratic Ordering in pDCPD‐Derived Hard Carbon Enables Stable Carbonate‐Based Sodium‐Ion Storage

Advanced Science, EarlyView.
Hard carbon derived from templated poly(dicyclopentadiene) as anode for sodium–ion batteries was engineered through carbonization and second‐step CO2${\rm CO}_2$ activation. High‐temperature carbonization and activation increased local ordering while reducing defects without inducing structural fracture.
David Schuster, Glen J. Smales, Max Schmallegger, Julian M Rosalie, Konstantin Kraushaar, Andreas Lißner, Julia Bohdal, Pia Winter, Bernd Fuchsbichler, Stefan Koller, Sebastijan Kovačič, Christian Slugovc   +11 more
wiley   +1 more source

Histone Lactylation Drives WNK1 Expression to Promote Esophageal Squamous Cell Carcinoma Progression Through Histone H3 Ser10 Phosphorylation

Advanced Science, EarlyView.
In brief. Yan et al. demonstrated that the excess lactate produced by the enhanced glycolysis pathway in esophageal cancer can lactylate H3K23, H3K23la can be enriched in the WNK1 promoter region to promote WNK1 expression, thereby increasing the phosphorylation of the p‐H3 Ser10 site, and p‐H3S10 can be enriched in the AKT1 promoter region to promote ...
Mingyang Yan, Shaobo Fang, Yanming Song, Lei Zhang, Kexin Zhao, Zhenwei Wang, Yang Shao, Meng Liu, Xinyang Jia, Qinxin Guo, Mee‐Hyun Lee, Guoguo Jin, Zigang Dong   +12 more
wiley   +1 more source

Cancer metabolism: The Warburg effect today

Experimental and Molecular Pathology, 2010
One of the first studies on the energy metabolism of a tumour was carried out, in 1922, in the laboratory of Otto Warburg. He established that cancer cells exhibited a specific metabolic pattern, characterized by a shift from respiration to fermentation, which has been later named the Warburg effect.
openaire   +2 more sources

pH‐Responsive Nanoplatform‐Mediated Lipid Hijacking and Metabolic Collapse for Synergistic Starvation‐Immunotherapy

Advanced Science, EarlyView.
A pH‐responsive ZIF‐8/2‐DG@Cu‐TA nanoplatform orchestrates multifaceted metabolic disruption for synergistic starvation‐immunotherapy. Acid‐triggered 2‐DG release blocks glycolysis, while Zn2+ overload induces mitochondrial dysfunction. Concurrently, Cx43‐mediated gap junctions redirect lipid droplets from tumor cells to cancer‐associated fibroblasts ...
Xianlong Zong, Haochen Yao, Danyang Shen, Furu Gong, Zixuan Wang, Haoyang Qin, Yang Yang, Ruirui Qiao, Yongjuan Li, Rui Li   +9 more
wiley   +1 more source

Formation‐Stage Interfacial Regulation of δ‐MnO2 Enables Stable and Reversible Aqueous Zn‐Ion Storage

Advanced Science, EarlyView.
Precursor‐embedded Fe regulates the nucleation and growth of δ‐MnO2, enabling a more accessible and stable Zn‐storage interface with accelerated kinetics and suppressed Mn dissolution, while preserving the intrinsic Mn redox chemistry. ABSTRACT Layered δ‐MnO2 is a promising cathode for aqueous zinc‐ion batteries, yet its practical application remains ...
Fanghua Liang, Ling Wang, Junpeng Xiong, Chunqing Niu, Atsuya Kawai, Wei Zhang, Chunhong Zhu, Azeem Ullah, Mayakrishnan Gopiraman, Mingzheng Ge, Ick Soo Kim   +10 more
wiley   +1 more source

Lactate Homeostasis Disruption Potentiates TACE‐Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Lactate homeostasis is disrupted through spatially coordinated extracellular neutralization and intracellular acidification, triggering calcium overload, mitochondrial dysfunction, and immunogenic cell death. This metabolic reprogramming alleviates the immunosuppressive tumor microenvironment and enhances immune checkpoint blockade, providing a ...
Minjiang Chen, Xiaoxiao Chen, Baozhu Yang, Hui Xu, Xueting Sun, Hongkai Qi, Huilin Hu, Ronghua Wu, Fengkai Qiu, Bing Wu, Yu Luo, Gaofeng Shu, Jiansong Ji   +12 more
wiley   +1 more source

UCP2 Mediation of the Warburg Effect in Chemoresistant Cancers

, 2012
In this paper, I focus on the role of uncoupling proteinâ€2 (UCP2) in mediating the Warburg effect in a particular pathway that has been accumulating evidence as the metabolic strategy behind chemoâ€resistant ...
Kim, Angela Hye-Jee
core   +1 more source

Gel‐Free Capture of Microvolt‐Level Neural Signatures Via a 3D Monolithic Carbon Fiber Dry Electrode

Advanced Science, EarlyView.
A compressible carbon fiber/PEDOT:PSS electrode enables gel‐free contact at hairy scalp sites. Its conductive porous framework supports low interfacial impedance and retains contact performance after repeated mechanical and sweat‐related challenges.
Haoxuan Sun, Nikolay Novitskiy, Dongwook Jang, Yixiang Liu, Shaoqi Pan, Ting Huang, Yitong Li, Huisi Yang, Leonardo Nicholas Adi Wijaya, Md Masruck Alam, Patrick CM Wong, Zhaoli Gao   +11 more
wiley   +1 more source

Post‐Synthetic Cerium Modification of Commercial NCM811 for Concurrent Cycling and Safety Upgrading

Advanced Science, EarlyView.
Cerium ion doping and CeO2 coating work synergistically to reinforce commercial NCM811 cathodes. This strategy stabilizes the lattice and strengthens the interface against degradation and side reactions. The modified cathode shows enhanced rate capability and cycling stability.
Wei‐Wei Wang, Da‐Kun Chen, Wei Kang, Xiao‐Mei Wu, Qing Cao, Quan‐Fang Wang, Si‐Yuan Ma, Hai‐Long Wang, Jing‐Hua Tian, Zhong‐Qun Tian   +9 more
wiley   +1 more source

Association between individual Warburg‐related proteins and prognosis in colorectal cancer

The Journal of Pathology: Clinical Research
We previously showed that Warburg subtyping (low/moderate/high), based on the expression of six glycolytic proteins and transcriptional regulators [glucose transporter 1 (GLUT1), pyruvate kinase M2 (PKM2), lactate dehydrogenase A (LDHA), monocarboxylate ...
Kelly Offermans, Josien CA Jenniskens, Colinda CJM Simons, Iryna Samarska, Gregorio E Fazzi, Kim M Smits, Leo J Schouten, Matty P Weijenberg, Heike I Grabsch, Piet A van den Brandt   +9 more
doaj   +1 more source