Results 111 to 120 of about 133,879,868 (285)
Advanced Science, EarlyView.This work presents a clinically deployable simultaneous PET/MRI workflow which integrates hyperpolarized 13C imaging of metabolism and extracellular pH with [18F]FMISO PET to characterize hypoxia, acidosis, and metabolic reprogramming in feline sarcoma.
Martin Grashei +17 more
wiley +1 more source
Immunometabolism in Tuberculosis
Frontiers in Immunology, 2016 Immunometabolism, the study of the relationship between bioenergetic pathways and specific functions of immune cells, has recently gained increasing appreciation.
Lanbo eShi +2 more
doaj +1 more source
Warburg Effect Reshapes Tumor Immunogenicity
Cancer ResearchAbstract Tumor cells rewire their metabolism to fulfill the demands of highly proliferative cells. This changes cellular metabolism to adapt to fuel and oxygen availability for energy production and to increase the synthesis capacity of building blocks for cell division and growth. In addition,
José A. Enríquez, María Mittelbrunn
openaire +4 more sources
Structures of fluorescent analogues synthesised to investigate Warburg effect targeting in vitro.
, 2019 Structures of fluorescent analogues synthesised to investigate Warburg effect targeting in vitro.
Alexandra Glenister (6954539) +2 more
core +1 more source
Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer
Advanced Science, EarlyView.Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.
Meng Qian +11 more
wiley +1 more source
Predictive significance of glycolysis-associated lncRNA profiles in colorectal cancer progression
BMC Medical GenomicsBackground The Warburg effect is a hallmark characteristic of colorectal cancer (CRC). Despite extensive research, the role of long non-coding RNAs (lncRNAs) in influencing the Warburg effect remains incompletely understood.
Rui Mao +6 more
doaj +1 more source
Advanced Science, EarlyView.Three phenothiazine‐based polyamides featuring gradually strengthened electron‐withdrawing linkers are developed as high‐voltage cathodes for lithium‐organic batteries. The linker motif serves not only as a structural bridge to suppress solubility, but also as a functional design element that governs optoelectronic properties and electron/ion transport
Shujuan Cao +4 more
wiley +1 more source
Advanced Science, EarlyView.Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong +13 more
wiley +1 more source
A New Target for Hepatic Fibrosis Prevention and Treatment: The Warburg Effect
Frontiers in Bioscience-LandmarkHepatic fibrosis is a major public health problem that endangers human wellbeing. In recent years, a number of studies have revealed the important impact of metabolic reprogramming on the occurrence and development of hepatic fibrosis.
Meng Pan, Huanyu Li, Xiaoyan Shi
doaj +1 more source
Advanced Science, EarlyView.An N‐doped carbon‐confined Bi/Bi2O3 heterostructure enables ultrafast and reversible Bi0/Bi3+ phase conversion through heterointerface seeding. The pre‐established Bi/Bi2O3 interfaces provide nucleation‐active sites for heterophase regrowth, while the N‐C shell promotes electron transport and structural stability, overcoming kinetic limitations in ...
Jingwen Ma +9 more
wiley +1 more source