Results 91 to 100 of about 133,879,868 (285)

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Interaction networks of macrophage glycolysis and inflammation in sepsis: mechanisms and therapeutic potential

Frontiers in Immunology
Sepsis is a severe threat to human health with high mortality rates, but so far its pathogenesis is unclear and lacks effective therapeutic drugs. Macrophages function as one of the most important innate immune cells and play an integral role in the ...
Peiyao Luo, Hao Liu, Hao Liu, Ting Zhang, Ting Zhang, Wenfang He   +5 more
doaj   +1 more source

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

Nature Communications, 2019
Pulmonary hypertension is characterized by a metabolic switch similar to the Warburg effect in cancer. Here Dabral et al. describe a RASSF1a-HIF-1α feedforward loop driving the Warburg effect both in a mouse model of hypoxia-induced pulmonary ...
Swati Dabral, Christian Muecke, Chanil Valasarajan, Mario Schmoranzer, Astrid Wietelmann, Gregg L. Semenza, Michael Meister, Thomas Muley, Tamina Seeger-Nukpezah, Christos Samakovlis, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Rajkumar Savai, Soni S. Pullamsetti   +14 more
doaj   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Warburg Effect in Oncology

International Journal of Trends in OncoScience
The Warburg effect, defined by cancer cells’ preference for aerobic glycolysis over mitochondrial oxidative phosphorylation for energy production, has been a central topic in cancer research since its identification in 1924. This process involves elevated glucose uptake and lactate production, even in the presence of oxygen, supporting rapid cell ...
Dr. T. Shehnaz Begum, Prof Dr. Ammar A. Razzak Mahmood, Maya Prabhakaran Pillai V, Dr. John Abraham, Dr. Vanitha Innocent Rani, Amutha Chellathurai, Dr. Somenath Ghosh   +6 more
openaire   +1 more source

Interfacial Interaction‐Engineered Dual Lithiophilic Ultrathin Interlayers for Dendrite‐Suppressed Lithium Metal Textile Anodes

Advanced Science, EarlyView.
Ultrathin lithiophilic interlayers engineered on a 3D textile electrode and separator cooperatively regulate interfacial Li nucleation and Li+ transport, leading to homogeneous Li plating and mitigated dendrite formation. The resulting dual‐interfacial design provides long‐term cycling stability, improved full‐cell durability, and a scalable pathway ...
Chanseok Lee, Donghyeon Nam, Sang Hun Baeck, Boyeon Kim, Yongkwon Song, Jaemin Kim, Daegun Kim, Jun Hyuk Moon, Yoon Jang Chung, Hyeong Jun Kim, Seoin Back, Yongmin Ko, Jinhan Cho   +12 more
wiley   +1 more source

Data for: 125I suppressed the Warburg effect via regulating miR-338/PFKL axis in hepatocellular carcinoma

, 2019
Data for: 125I suppressed the Warburg effect via regulating miR-338/PFKL axis in hepatocellular ...
Jiaping Zheng (7362740), Hui Zeng (142702), Jun Luo (120285), Guoliang Shao (4908157), Liwen Guo (1447288)   +4 more
core   +1 more source

Gate Metal‐Driven Sensing and Memory Bifunctionality in Intrinsically Stretchable Organic Electrochemical Transistors for Soft Neuromorphic Systems

Advanced Science, EarlyView.
Intrinsically stretchable OECTs enable bifunctional operations via gate engineering. Polarizable Ag/AgCl gates provide volatile sensing, while Au gates enable non‐volatile memory. The SEBS‐blended channel maintains performance under strain, supporting reliable signal transduction.
Jiyong Yoon, Jaepyo Jang, Hyunjin Jung, Duhwan Seong, Daeun Kim, Yewon Jeon, Ja Hoon Koo, Sang Min Won, Donghee Son   +8 more
wiley   +1 more source