Protein hydrolysates of Moringa oleifera seed: Antioxidant and antihyperglycaemic potential as ingredient for the management of type-2 diabetes [PDF]
HeliyonNew plant proteins with high nutritional quality and biological properties are actively searched worldwide. Moringa oleifera seed protein isolate was prepared from defatted flour and hydrolyzed using four proteases namely trypsin, pepsin, Alcalase, and ...
Christian Bernard Bakwo Bassogog +7 more
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Serine protease inhibitor dipetalogastin-like from Galleria mellonella is involved in insect immunity [PDF]
Scientific ReportsA new protein with immune properties was found in Galleria mellonella hemolymph. The so-far putative serine protease inhibitor dipetalogastin-like (GmSPID) was found in one fraction obtained after separation of hemolymph by RP-HPLC.
Jakub Kordaczuk +4 more
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Angiotensin-converting enzyme inhibitor activity of peptides derived from Kacang goat skin collagen through thermolysin hydrolysis [PDF]
Veterinary World, 2021 Background and Aim: Angiotensin-converting enzyme (ACE) is one of the inhibitory enzymes isolated from animals for the treatment of hypertension.
Arby'in Pratiwi +6 more
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Molecules, 2023 β-casein, a protein in milk and dairy products, has two main variant forms termed as A1 and A2. A1 β-casein may have adverse effects on humans. The fact that there is only one amino acid variation at the 67th position between A1 and A2 β-casein makes it ...
Zeyang Liu +4 more
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Engineered B7-H3 Binding in Modular Gp2 Miniproteins. [PDF]
Biotechnol BioengABSTRACT B7‐H3, an important immune checkpoint modulator of T‐cell function, is a tumor vasculature biomarker and is overexpressed in a variety of cancers. Its expression is associated with tumor growth, metastasis, and poor clinical prognosis, which makes B7‐H3 an appealing target for diagnostics and therapeutics.
Harthorn A +5 more
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Casein Proteolysis in Bioactive Peptide Production: Optimal Operating Parameters [PDF]
Техника и технология пищевых производств, 2020 Introduction. Public health is gradually deteriorating as a result of unhealthy lifestyle and diet, which triggers allergic reaction to certain foods.
Milentyeva Irina S. +2 more
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Hayati Journal of Biosciences, 2023 Proteolytic enzymes are widely used to produce protein hydrolysates that contain bioactive peptides. Some of bioactive peptides are known inhibit the angiotensin-I-converting enzyme (ACE, EC 3.4.15.1) and act as human antihypertensive.
Dininurilmi Putri Suleman +2 more
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Bacterial Zinc Metalloenzyme Inhibitors: Recent Advances and Future Perspectives
Molecules, 2023 Human deaths caused by Gram-negative bacteria keep rising due to the multidrug resistance (MDR) phenomenon. Therefore, it is a priority to develop novel antibiotics with different mechanisms of action.
Riccardo Di Leo +3 more
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Evaluation of new antihypertensive drugs designed in silico using Thermolysin as a target
Saudi Pharmaceutical Journal, 2020 The search for new therapies for the treatment of Arterial hypertension is a major concern in the scientific community. Here, we employ a computational biochemistry protocol to evaluate the performance of six compounds (Lig783, Lig1022, Lig1392, Lig2177,
Desmond MacLeod-Carey +3 more
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Isolation and identification of angiotensin I-converting enzyme inhibitory peptides derived from thermolysin-injected beef [PDF]
Asian-Australasian Journal of Animal Sciences, 2019 Objective This study identified angiotensin I-converting enzyme (ACE) inhibitory peptides in beef M. longissimus injected with thermolysin (80 ppm) and stored for 3 days at 5°C. Methods Crude peptides (molecular weight
Juhui Choe +5 more
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