Results 71 to 80 of about 67,735 (340)

Exploring the Effects of Different Classroom Environments on the Learning Process. Synthesis of Thiazole-Linked Porous Organic Polymers for CO2 Separation and Nitro-Aromatics Sensing. [PDF]

, 2017
When attempting to study the learning process of undergraduate chemistry student, the classroom and any interaction that take place within it constitute the social context of interest.
D\u27Urbino, Davide
core   +1 more source

Methyl 2-amino-5-iso­propyl-1,3-thia­zole-4-carboxyl­ate [PDF]

, 2004
The title compound, C8H12N2O2S, forms a supramolecular network based on N-HN hydrogen-bonded centrosymmetric dimers that are linked in turn by N-HO ...
Kennedy, Alan R., Khalaf, Abedawn I., Suckling, Colin J., Waigh, Roger D.   +3 more
core   +1 more source

Dual‐Locking the SARS‐CoV‐2 Spike Trimer: An Amphipathic Molecular “Bolt” Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition

Advanced Science, EarlyView.
A new amphipathic molecule, S416 is discovered, that locks the SARS‐CoV‐2 spike protein in its closed state, blocking viral entry. S416 acts as a molecular bolt, binding six sites: three between adjacent RBDs and three connecting NTDs to RBDs. This dual‐locking mechanism stiffens the spike structure and reduces its flexibility.
Shiliang Li, Fang Ye, Yucheng Zheng, Jie Wang, Haoran Peng, Lili Zhu, Lili Chen, Tao Yu, Huan Ge, Jiaqi He, Binghao Zhang, Jiayun Wu, Zhiyi Zhang, Liangliang Jiang, Geng Chen, Ping Zhao, Ke Lan, Zhenjiang Zhao, Xuhong Qian, Ke Xu, Yang Du, Honglin Li   +21 more
wiley   +1 more source

Ranking ligand affinity for the DNA minor groove by experiment and simulation [PDF]

, 2010
The structural and thermodynamic basis for the strength and selectivity of the interactions of minor-groove binders (MGBs) with DNA is not fully understood.
Anthony N. G., Anthony N. G., Anthony N. G., Bailly C., Chaires J. B., Dervan P. B., Duan Y., Feig M., Freyer M. W., Hamdan I., Hawkins G. D., James P. L., Khalaf A. I., Kopka M. L., Kopka M. L., Lane A. N., Misra V. K., Mrksich M., Patel D. J., Pelton J. G., Syme N. R., Trauger J. W., Treesuwan W., Wade W. S., Wittayanarakul K.   +24 more
core   +2 more sources

In Situ Assembly of Fluorogenic RNA for Screening Natural Anti‐Liver Fibrosis Products via Dynamic Visualization of COL1A1 mRNA

Advanced Science, EarlyView.
This study introduces an in situ assembly of fluorogenic RNA approach for screening natural anti‐liver fibrosis compounds and dynamic visualization of endogenous COL1A1 mRNA in live cells. It offers a simple, cost‐effective approach of visualizing RNA dynamics and conducting drug screening in live cells, presenting a significant potential for the ...
Rui Bai, Li‐Zeng Zhu, Changfa Shao, Zheng Yin, Qun Liu, Yu Gu, Bin Liu   +6 more
wiley   +1 more source

Discovery of Bisamide-heterocycles as Inhibitors of Scavenger Receptor BI (SR-BI)-mediated Lipid Uptake [PDF]

, 2015
A new series of potent inhibitors of cellular lipid uptake from HDL particles mediated by scavenger receptor, class B, type I (SR-BI) was identified. The series was identified via a high-throughput screen of the National Institutes of Health Molecular ...
Bennion, Melissa, Dandapani, Sivaraman, Dockendorff, Chris, Faloon, Patrick W., Germain, Andrew, Krieger, Monty, Munoz, Benito, Nag, Partha P., Nieland, Thomas J.F., Palmer, Michelle A., Penman, Marsha, Perez, José R., Schreiber, Stuart L., Youngsaye, Willmen, Yu, Miao   +14 more
core   +2 more sources

Thiazole-Bearing 4-Thiazolidinones as New Anticonvulsant Agents

Scientia Pharmaceutica, 2020
Here, we describe the synthesis and anticonvulsant activity of thiazole-bearing hybrids based on 2-imino-4-thiazolidinone and 2,4-dioxothiazolidine-5-carboxylic acid cores.
M. Mishchenko, S. Shtrygol’, D. Kaminskyy, R. Lesyk   +3 more
semanticscholar   +1 more source

Synthesis, modeling, and biological studies of new thiazole-pyrazole analogues as anticancer agents

Journal of Saudi Chemical Society, 2023
A series of various substituted thiazole-pyrazole hybrids 5, 7, 8, and 9 were synthesized, and their chemical structures were confirmed by spectral data (infrared, 1H & 13C NMR and Mass).
Gadeer R.S. Ashour, Ahmad Fawzi Qarah, Abdulmajeed F. Alrefaei, Adel I. Alalawy, Amerah Alsoliemy, Alaa M. Alqahtani, Wael M. Alamoudi, Nashwa M. El-Metwaly   +7 more
doaj  

closo‐Carboranylanaloga von β‐Arylethylaminen: Direkte Synthese aus Alkenen mittels EnT‐Katalyse

Angewandte Chemie, EarlyView.
Eine Strategie zur direkten Synthese von closo‐Carboranylanaloga medizinisch relevanter β‐Arylethylamine aus Alkenen wird vorgestellt. Die Reaktion basiert auf der erstmaligen Erzeugung von closo‐Carboranylradikalen mittels Energietransfer‐(EnT)‐Katalyse und ihren besonderen mechanistischen Merkmalen.
Fritz Paulus, Corinna Heusel, Marc Jaspers, Lilli M. Amrehn, Florian Schreiner, Debanjan Rana, Constantin G. Daniliuc, Michael Ryan Hansen, Frank Glorius   +8 more
wiley   +1 more source

Molecular modeling and docking studies of new antimicrobial antipyrine-thiazole hybrids

Arabian Journal of Chemistry, 2022
A series of new antipyrine incorporated thiazole derivatives having phenoxyacetamide moiety as a link bridge was synthesized. The synthetic strategy involves condensation of the precursor N-(4-antipyrinyl)-2-(4-formylphenoxy)acetamide with ...
Sraa Abu-Melha
doaj