Results 1 to 10 of about 44,050 (359)

Reactions of acryl thioamides with iminoiodinanes as a one-step synthesis of N-sulfonyl-2,3-dihydro-1,2-thiazoles [PDF]

Beilstein Journal of Organic Chemistry
A one-step method has been developed for the preparation of 2,3-dihydro-2-sulfonyl-3,4,5-substituted 1,2-thiazoles by the reaction of acryl thioamides and iminoiodinanes.
Vladimir G. Ilkin, Pavel S. Silaichev, Valeriy O. Filimonov, Tetyana V. Beryozkina, Margarita D. Likhacheva, Pavel A. Slepukhin, Wim Dehaen, Vasiliy A. Bakulev   +7 more
doaj   +2 more sources

Photochemical permutation of thiazoles, isothiazoles and other azoles. [PDF]

Nature
Thiazoles and isothiazoles are privileged motifs in drug and agrochemical discovery1,2. The synthesis of these derivatives is generally approached, designed and developed on a case-by-case basis. Sometimes, the lack of robust synthesis methods to a given
Roure B, Alonso M, Lonardi G, Yildiz DB, Buettner CS, Dos Santos T, Xu Y, Bossart M, Derdau V, Méndez M, Llaveria J, Ruffoni A, Leonori D.   +12 more
europepmc   +2 more sources

Synthesis of Thiazoles and Isothiazoles via Three-Component Reaction of Enaminoesters, Sulfur, and Bromodifluoroacetamides/Esters

Organic Letters, 2020
A three-component strategy for the synthesis of thiazoles and isothiazoles has been developed by employing enaminoesters, fluorodibromoiamides/ester, and sulfur.
Yao Zhou, Qiuling Song
exaly   +2 more sources

Mechanochemical Approach for Metal-Free Regioselective C5-Sulfenylation of Imidazo[2,1-b]Thiazoles. [PDF]

ChemSusChem
This study presents a mechanochemical approach for the metal‐free, regioselective C5‐sulfenylation of imidazo[2,1‐b]thiazoles using bis(trifluoroacetoxy)iodo]benzene and aryl methyl sulfides. The method, performed under solvent‐free ball‐milling conditions, provides an efficient, environmentally friendly alternative to conventional synthesis, achieving
Liu X, Dorokhov V, Provot O, Tran C, Retailleau P, Soulé JF, Hamze A.   +6 more
europepmc   +2 more sources

Combined in Vitro and in Silico Studies for the Anticholinesterase Activity and Pharmacokinetics of Coumarinyl Thiazoles and Oxadiazoles

Frontiers in Chemistry, 2018
In a continuation of our previous work for the exploration of novel enzyme inhibitors, two new coumarin-thiazole 6(a–o) and coumarin-oxadiazole 11(a–h) hybrids have been designed and synthesized.
Ajmal Khan, Rizwana Sarwar, Umar Farooq
exaly   +2 more sources

Novel hybrid thiazoles, bis-thiazoles linked to azo-sulfamethoxazole: Synthesis, docking, and antimicrobial activity [PDF]

Heliyon
The reaction of sulfamethoxazolehydrazonoyl chloride with thiosemicarbazones, bis-thiosemicarbazones, or 4-amino-3-mercapto-1,2,4-triazole in dioxane in the presence of triethylamine as a basic catalyst at reflux resulted in the regioselective synthesis ...
Mostafa E. Salem, Ismail A. Abdelhamid, Ahmed H.M. Elwahy, Mohamed A. Ragheb, Arwa sultan Alqahtani, Magdi E.A. Zaki, Faisal K. Algethami, Huda Kamel Mahmoud   +7 more
doaj   +2 more sources

Novel Structural Hybrids of Pyrrole and Thiazole Moieties: Synthesis and Evaluation of Antibacterial and Antifungal Activities

Acta Chimica Slovenica, 2021
One of the best ways to design new biocidal agents is synthesizing hybrid molecules by combining two or more bioactive moieties in a single molecular scaffold.
Mohamed Salem, Samir Abbas, Marwa El-Sharief, Mohamed Helal, Moustafa Gouda, Mohammed Assiri, Mohammed Assiri, Tarik Ali, Tarik Ali   +8 more
doaj   +1 more source

Thiazoles: A Retrospective Study on Synthesis, Structure-activity Relationship and Therapeutic Significance

Indian Journal of Pharmaceutical Education and Research, 2022
Thiazole or 1,3-thiazole is a distinct heterocyclic compound which incorporates sulphur and nitrogen atoms. It is a vital framework present in numerous pharmacologically active compounds, be it of natural origin or of synthetic nature.
Shivkant Sharma, M. Devgun, R. Narang, S. Lal, A. Rana   +4 more
semanticscholar   +1 more source

Thiazole Ring—A Biologically Active Scaffold

Molecules, 2021
Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical applications. Its derivatives have a wide range of biological activities such as antioxidant, analgesic, and antimicrobial including antibacterial, antifungal ...
Anthi Petrou, Maria Fesatidou, Athina Geronikaki   +2 more
doaj   +1 more source

Synthesis of Novel Thiazole Derivatives Bearing β-Amino Acid and Aromatic Moieties as Promising Scaffolds for the Development of New Antibacterial and Antifungal Candidates Targeting Multidrug-Resistant Pathogens

Molecules, 2021
Rapidly growing antimicrobial resistance among clinically important bacterial and fungal pathogens accounts for high morbidity and mortality worldwide.
Dovilė Malūkaitė, Birutė Grybaitė, Rita Vaickelionienė, Giedrius Vaickelionis, Birutė Sapijanskaitė-Banevič, Povilas Kavaliauskas, Vytautas Mickevičius   +6 more
doaj   +1 more source