Results 171 to 180 of about 45,916 (341)

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang   +32 more
wiley   +1 more source

Mechanochemical Synthesis of X‐Vinylbenziodoxol(on)es and One‐Pot Conversion to Complex Alkenes**

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
The synthesis of a wide range of complex 1,2‐di(heteroatom)‐substituted (Z)‐alkenes is achieved through a mechanochemical one‐pot reaction of ethynylbenziodoxol(on)es (EBX/EBO) with a variety of heteroatom nucleophiles. The mechanochemical activation enables synthesis of a range of novel vinylbenziodoxol(on)es (VBX/VBO) whose synthesis is inefficient ...
Sayad Doobary, Judith Braunreuther, Andrew K. Inge, Berit Olofsson   +3 more
wiley   +2 more sources

Truncated Conjugate Structure Improves Solar‐Driven Hydrogen Peroxide Production Catalyzed by Benzobisthiazole‐Based Conjugated Polymers

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In this work, a novel molecular design strategy was employed to truncate large‐scale conjugated structures in covalent polymer materials. This approach significantly enhances the catalyst’s light‐harvesting capability, prolongs the lifetime of photogenerated charge carriers, and improves catalytic activity, thereby offering a new conceptual pathway for
Cui Li, Qirui Wang, Shu Lin, Xianglin Xiang, Kezhen Qi   +4 more
wiley   +1 more source

Fluorinated Derivatives of Benz[4,5]imidazo[1,2-b][1,3] thiazole—Inhibitors of Reproduction of Measles Virus [PDF]

, 2004
А. Г. Покровский, Т. Н. Иличева, S. K. Kotovskaya, С. А. Романова, Valery N. Charushin, Олег Н. Чупахин   +5 more
openalex   +1 more source

Epoxidised Natural Rubber (ENR)/Wollastonite Composites for Tyre Inner Liners: A Practical Replacement for Butyl Rubber in Industrial Applications

Polymer Engineering &Science, Volume 66, Issue 2, Page 1153-1169, February 2026.
Replacing butyl rubber with ENR+Wollastonite in tyre inner‐liners. ABSTRACT This study aimed to develop epoxidised natural rubber (ENR)‐based rubber compound formulations as an alternative to butyl rubber for tyre inner liners. The effects of different vulcanization systems, designed to achieve similar curing behavior in NR‐based carcass compounds and ...
Tuba Ünügül Yavuz, Abdussalam Essa, Ronak Janani, Bağdagül Karaağaç, Christopher Sammon   +4 more
wiley   +1 more source

Methyl (1aRS,7aSR)-7-formyl-1a-phenyl-1,1a-dihydroazirino[2,3-b]benzo[e][1,4]thiazine-7a(7H)-carboxylate

Molbank
The first representative of the aziridine-fused benzo[e][1,4]thiazine series was synthesized from methyl 2-bromo-2-phenyl-2H-azirine-2-carboxylate and benzo[d]thiazole in 74% yield.
Ilya P. Filippov, Anastasiya V. Agafonova, Nikolai V. Rostovskii, Mikhail S. Novikov   +3 more
doaj   +1 more source

Design, synthesis, and SAR of novel thiazole-based antimicrobials targeting DNA gyrase: In vitro and in silico profiling [PDF]

О. Shevchenko, Victoria Kovalenko, Yulia V Tarasenko, D.P. Ivanov   +3 more
openalex   +1 more source

Conformational dynamics in insulin receptor kinase reveal a type III allosteric pocket

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Allosteric modulation is a promising strategy for selective kinase inhibition, yet structural insights into allosteric pockets remain limited across the human kinome. In this work, we present comprehensive characterization of a type III allosteric pocket in the insulin receptor kinase (IRK), integrating structural, conformational, and ...
Jyoti Verma, Harish Vashisth
wiley   +1 more source

The Role of Soil Microorganisms in Microplastic Biodegradation: Mechanisms, Carbon Preferences, and Ecological Impacts

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
This work explores the complex relationship between soil carbon availability and microplastic biodegradation, highlighting competition and symbiosis among microorganisms, the repurposing of microplastic‐derived polymers, and the impact of soil organic carbon on microbial substrate preferences and carbon use efficiency variability.
Mohammad Yaghoubi Khanghahi, Carmine Crecchio, Adriano Sofo, Rosangela Addesso   +3 more
wiley   +1 more source

Novel hybrid thiazoles, bis-thiazoles linked to azo-sulfamethoxazole: Synthesis, docking, and antimicrobial activity

Heliyon
The reaction of sulfamethoxazolehydrazonoyl chloride with thiosemicarbazones, bis-thiosemicarbazones, or 4-amino-3-mercapto-1,2,4-triazole in dioxane in the presence of triethylamine as a basic catalyst at reflux resulted in the regioselective synthesis ...
Mostafa E. Salem, Ismail A. Abdelhamid, Ahmed H.M. Elwahy, Mohamed A. Ragheb, Arwa sultan Alqahtani, Magdi E.A. Zaki, Faisal K. Algethami, Huda Kamel Mahmoud   +7 more
doaj   +1 more source