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Vergleich der Dissoziationskonstanten von 2-Amino-thiazol- und 2-Amino-oxazol-Derivaten
CHIMIA, 1973 A description is given for the synthesis by standard methods of 2-Amino-4-phenyl- and 2-Amino-5-phenyl-thiazoles having different para-substituents together with the 2-Amino-4-phenyl-oxazole analogues. The pKa-values were determined for the compounds in
U. Stauss, H.P. Härter, O. Schindler
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Selected 5-amino-1-aryl-1H-1,2,3-triazole scaffolds as promising antiproliferative agents [PDF]
The Ukrainian Biochemical Journal, 2020 Development of a new effective drugs with low side effects and definite chemical characteristics needs indentification of bioactive scaffolds for further structural optimization.
N. Pokhodylo +3 more
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Crystal structure of 4-(benzofuran-2-yl)-2-(3-(4-fluorophenyl)-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl)thiazole, C28H20FN3OS [PDF]
, 2016 C28H20FN3OS, triclinic, P1̅ (no. 2), a = 9.5719(5) Å, b = 10.7499(6) Å, c = 10.9238(5) Å, α = 95.470(4)°, β = 102.133(4)°, γ = 97.962(4)°, V = 1079.30(10) Å3, R gt(F) = 0.0482, wR ref(F 2) = 0 ...
Abdel-Wahab, Bakr F. +4 more
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Scientific Electronic ArchivesThe thiosemicarbazones and thiazoles are known for their versatility of biological activities, among which we can mention: antioxidant, antimicrobial, anticancer activity and the ability to interact with biological macromolecules, HSA and DNA. This study
Pedro Henrique do Bomfim Nascimento +7 more
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Nanomaterials, 2018 A chitosan-MgO hybrid nanocomposite was prepared using a simple chemical precipitation method and characterized using Fourier transform spectroscopy (FTIR), elemental analysis (EDX), and scanning electron microscopy (SEM). The nanocomposite was served as
Sayed M. Riyadh +2 more
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Development of Novel Pyridine-Thiazole Hybrid Molecules as Potential Anticancer Agents
Molecules, 2022 Novel pyridine-thiazole hybrid molecules were synthesized and subjected to physico-chemical characterization and screening of their cytotoxic action towards a panel of cell lines derived from different types of tumors (carcinomas of colon, breast, and ...
Iryna Ivasechko +15 more
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A Unique Tryptophan C‐Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway [PDF]
, 2016 Acknowledgements This work was supported by funding of the Academy of Finland (259505), Helsinki University Research grant (490085) and ESCMID grant (4720572) to D.P.F., University of Pittsburgh Central Research Development Fund to X.L., Technology ...
Arnison +21 more
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, 1974 Department of Chemistry, Punjab University, Chandigarh-160014 Manuscript received 11 February 1974; accepted 20 August 1974 Some Pyrazolo(3,4-d)-thiazoles have been synthesised by the condensation of phenyl thioureas with 4-bromo-1,3 diphenyl pyrazolone-5. However, In each case, two products have been isolated.
H. K. GAKHAR, VED PARKASH, KUL BHUSHAN
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Structural Basis for the Catalytic Mechanism of ATP‐Dependent Diazotase CmaA6
Angewandte Chemie, EarlyView.Several diazotases have been reported in recent years, but the detailed catalytic mechanism is unclear. From X‐ray crystallography and Cryo‐EM analysis, we obtained the structure of a diazotase CmaA6, which synthesizes 3‐diazocoumaric acid. Kinetic analysis and computational analysis indicated that CmaA6 catalyzes diazotization via an unprecedented ...
Seiji Kawai +5 more
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Біологічні студії, 2018 One of the main problems of chemotherapy is development of negative side effects, when anti-tumor drugs damage healthy cells, in particular hepatocytes. Liver is the main detoxifying organ in human and animals.
Ya. R. Shalai +4 more
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