Results 51 to 60 of about 45,916 (341)

Microwave-assisted generation and reactivity of aza- and diazafulvenium methides: heterocycles via pericyclic reactions [PDF]

, 2008
Azafulvenium methides and diazafulvenium methides have been generated under microwave irradiation from 2,2-dioxo-1H,3H-pyrrolo[1,2-c]thiazoles and 2,2-dioxo-1H,3H-pyrazolo[1,5-c]thiazoles, respectively.
Melo, Teresa M. V. D. Pinho e, Soares, Maria I. L.   +1 more
core   +1 more source

Polysaccharide‐Coated ETCA Nanoparticles Containing the Methoxyl Substituted Indole‐Thiazole Derivative and Their Antiproliferative Activity in Breast Cancer Cells [PDF]

Journal of Applied Polymer Science, Volume 143, Issue 4, January 20, 2026.
ABSTRACT Indole and thiazole derivatives have garnered significant attention due to their potent antitumor activities. Encapsulation of such derivatives into polymeric nanoparticles offers several advantages, including improved molecular stability and targeted delivery to tumor sites, thereby enhancing their antineoplastic potential.
José Cleberson Santos Soares, Iago Dillion Lima Cavalcanti, Iranildo José da Cruz Filho, Mariane Cajubá de Britto Lira Nogueira, Maria do Carmo Alves de Lima   +4 more
openalex   +2 more sources

Vergleich der Dissoziationskonstanten von 2-Amino-thiazol- und 2-Amino-oxazol-Derivaten

CHIMIA, 1973
A description is given for the synthesis by standard methods of 2-Amino-4-phenyl- and 2-Amino-5-phenyl-thiazoles having different para-substituents together with the 2-Amino-4-phenyl-oxazole analogues. The pKa-values were determined for the compounds in
U. Stauss, H.P. Härter, O. Schindler
doaj   +1 more source

An Overview of the Structure–Activity Relationship in Novel Antimicrobial Thiazoles Clubbed with Various Heterocycles (2017–2023)

Pharmaceutics
Antimicrobial resistance is an increasing problem for global public health. One of the strategies to combat this issue is the synthesis of novel antimicrobials through rational drug design based on extensive structure–activity relationship studies.
Daniel Ungureanu, B. Tiperciuc, C. Nastasă, Ioana Ionuț, Gabriel Marc, I. Oniga, O. Oniga   +6 more
semanticscholar   +1 more source

EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2013. Scientific Opinion on Flavouring Group Evaluation 93, Revision 1 (FGE.93Rev1) [PDF]

, 2013
International ...
Aeschbacher, Cramer, EFSA (European Food Safety Authority), EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), Florin, JECFA (Joint FAO/WHO Expert Committee on Food Additives), JECFA (Joint FAO/WHO Expert Committee on Food Additives), JECFA (Joint FAO/WHO Expert Committee on Food Additives), Lee, Longfellow, Longfellow, Mihara, Mosier, SCF (Scientific Committee for Food), Shibuya T, Tanaka, Voogd, Watters, Zeiger   +20 more
core   +2 more sources

Frame-Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design. [PDF]

Angew Chem Int Ed Engl
Modern chemistry seeks to turn the simple raw materials into complex molecules that matter in health, agriculture, and technology. Among these, oligoheterocycles stand out for their versatility, yet they are most often built by cross‐coupling reactions that often rely on expensive metal catalysts.
Bastick KAC, Griesbach CE, Huang BZ, Cordell MJ, Ou YD, Aspuru-Guzik A, Yudin AK.   +6 more
europepmc   +3 more sources

Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

Angewandte Chemie, EarlyView.
A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu, Frederick Nguele Meke, Zheng Zhang, Aaron D. Krabill, Christine S. Muli, Brenson A. Jassim, Jiajun Dong, Quyen D. Nguyen, Yunpeng Bai, Jinyue Li, Yiming Miao, Bardia Asadi, Levi M. Johnson, Jinmin Miao, Darci J. Trader, W. Andy Tao, Zhong‐Yin Zhang   +16 more
wiley   +2 more sources

Safety and efficacy of thiazoles, thiophene and thiazoline belonging to chemical group 29 when used as flavourings for all animal species

EFSA Journal, 2016
Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 12 compounds belonging to chemical group 29 ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

Neuere heterocyclische Zwischenprodukte für die Azokupplung durch Cyclisierung von Nitrilen

CHIMIA, 1980
Two types of syntheses of heteroaromatic amines by cyclization of nitriles are described. It is dealt with the cyclization of nitriles by elemental sulphur yielding thiophenes and thiazoles and with some reactions of the resulting 2-amino-thiophene-3 ...
Karl Gewald
doaj   +1 more source

Thiazoles and Thiazolidinones as COX/LOX Inhibitors

Molecules, 2018
Inflammation is a natural process that is connected to various conditions and disorders such as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase isoenzymes (COX-1, COX-2) are responsible for the production of ...
K. Liaras, M. Fesatidou, A. Geronikaki
semanticscholar   +1 more source