Results 61 to 70 of about 2,082 (147)

1,2‐Diaza‐1,3‐Dienes as a Multifaceted Synthons for the Synthesis of Heterocycles: A Fifteen‐Years Update

European Journal of Organic Chemistry, Volume 27, Issue 44, November 25, 2024.
1,2‐Diaza‐1,3‐butadienes, also called azoalkenes, have received considerable attention as key synthons for constructing various heterocyclic scaffolds. This minireview summarizes the contribution of our group in this field over the period from 2009 to the present, focusing on the role of the azoene building block in forming the heterocyclic structures.
Lucia De Crescentini, Giacomo Mari, Stefania Santeusanio, Gianfranco Favi, Fabio Mantellini   +4 more
wiley   +1 more source

Quality of medicines commonly used in the treatment of soil transmitted helminths and Giardia in Ethiopia: a nationwide survey [PDF]

, 2014
Background: The presence of poor quality medicines in the market is a global threat on public health, especially in developing countries. Therefore, we assessed the quality of two commonly used anthelminthic drugs [mebendazole (MEB) and albendazole (ALB)]
D'Hondt, Matthias, De Spiegeleer, Bart, Deti, Habtewold, Duchateau, Luc, Levecke, Bruno, Mekonnen Kurmane, Zeleke, Vercruysse, Jozef, Wega, Sultan Suleman, Wynendaele, Evelien, Zeleke, Gemechu   +9 more
core   +3 more sources

Chiral Quaternary Ammonium Salt‐Catalyzed Enantioselective Addition Reactions of Hydantoins

Helvetica Chimica Acta, Volume 107, Issue 3, March 2024.
Abstract We herein report a protocol for the asymmetric 1,4‐addition of hydantoins to various Michael acceptors by utilizing Cinchona alkaloid‐based chiral quaternary ammonium salt catalysts. Various products were obtained with moderate to good enantioselectivities and accompanying computational investigations helped to identify key interactions ...
Katharina Röser, Lucas Prameshuber, Sajid Jahangir, Sharath Chandra Mallojjala, Jennifer S. Hirschi, Mario Waser   +5 more
wiley   +1 more source

The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs [PDF]

, 2017
A controlled inflammatory response is required for protection against infection, but persistent inflammation causes tissue damage. Dendritic cells (DCs) have a unique capacity to promote both inflammatory and anti-inflammatory processes.
Awuah, Dennis, Ghaemmaghami, Amir M., Negm, Ola H., Salazar, Fabián, Shakib, Farouk   +4 more
core   +1 more source

Dopaminergic neuronal death via necroptosis in Parkinson's disease: A review of the literature

European Journal of Neuroscience, Volume 59, Issue 6, Page 1079-1098, March 2024.
We reviewed the current literature on the potential role of necroptosis, a recently characterized regulated cell death mechanism, in Parkinson's disease (PD) pathogenesis. We summarized findings from studies on necroptosis in PD preclinical models and PD human tissue samples, discussing how manipulating necroptosis might open a novel therapeutic ...
Maria Regoni, Flavia Valtorta, Jenny Sassone   +2 more
wiley   +1 more source

Necrostatin‐1 releasing nanoparticles: In vitro and in vivo efficacy for supporting immunoisolated islet transplantation outcomes

Journal of Biomedical Materials Research Part A, Volume 112, Issue 2, Page 288-295, February 2024.
Abstract Immunoisolation of pancreatic islets in alginate microcapsules allows for transplantation in the absence of immunosuppression but graft survival time is still limited. This limited graft survival is caused by a combination of tissue responses to the encapsulating biomaterial and islets. A significant loss of islet cells occurs in the immediate
Alexandra M. Smink, Juan D. Medina, Bart J. de Haan, Andrés J. García, Paul de Vos   +4 more
wiley   +1 more source

Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea

Beilstein Journal of Organic Chemistry, 2019
A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed.
Aleksandr I. Kobelev, Nikita A. Tretyakov, Ekaterina E. Stepanova, Maksim V. Dmitriev, Michael Rubin, Andrey N. Maslivets   +5 more
doaj   +1 more source

A comparison of the exposure system of glycidol‐related chemicals on the formation of glycidol‐hemoglobin adducts

Food Science &Nutrition, Volume 12, Issue 1, Page 471-480, January 2024.
The exposure systems of glycidol‐related chemicals on the formation of glycidol‐hemoglobin adducts diHOPrVal were compared. DiHOPrVal formation was observed using several chemicals other than glycidol with different behaviors in vitro and in vivo. However, in both cases, the amount of diHOPrVal produced was very small compared with glycidol. This study
Yuko Shimamura, Yuri Wada, Moeka Tashiro, Hiroshi Honda, Shuichi Masuda   +4 more
wiley   +1 more source

Microwave Assisted Synthesis of Novel Functionalized Hydantoin Derivatives and Their Conversion to 5-(Z) Arylidene-4H-imidazoles

Molecules, 2011
2-(Alkyl-1-yl)-1H-imidazol-5(4H)-ones 5a–n were synthesized via nucleophilic substitution of the methylsulfanyl group of the corresponding 2-(methylthio)-1H-imidazol-5(4H)-ones 3a–c with suitably substituted secondary amines.
Edward R. Biehl, Haribabu Ankati, Sukanta Kamila   +2 more
doaj   +1 more source

Kinetics and mechanism of amino acid derived 2-thiohydantoin formation reactions [PDF]

, 2022
The reaction of allyl isothiocyanate with some common natural protein amino acids (glycine, l-alanine, l-valine, l-leucine and l-phenylalanine) was monitored.
Milenkovic, Dejan, Stanić, Petar, Šmit, Biljana   +2 more
core   +2 more sources