Results 81 to 90 of about 1,246 (203)

Investigating the Kinetic Impact of DMSO on Platinum(II) Coordination: An Experimental and Computational Study of Cisplatin and 2-Thiohydantoin Ligands

Inorganics
This study presents a thorough investigation of chemical outcomes during the reaction of cisplatin and 2-thiohydantoin ligands in the presence of DMSO. Aided by NMR spectroscopy and quantum chemical calculations, the influence of DMSO substitution on the
Petar B. Stanić, Amina I. Nurović, Tanja V. Soldatović, Darko P. Ašanin, Marko V. Rodić, Biljana M. Šmit, Goran V. Janjić   +6 more
doaj   +1 more source

Design, synthesis and evaluation of anticancer activity of novel 2-thioxoimidazolidin-4-one derivatives bearing pyrazole, triazole and benzoxazole moieties

Chemistry Central Journal, 2018
A novel series of substituted 2-thiohydantoin incorporated with benzoimidazole, pyrazole, triazole and/or benzoxazole moieties has been synthesized using (E)-3-[1-(4-bromophenyl)ethylideneamino]-2-thioxoimidazolidin-4-one 1 as the key starting material ...
Heba A. Elhady, Refat El-Sayed, Hamedah S. Al-nathali   +2 more
doaj   +1 more source

Synthesis and characterization of a methacrylate monomer with a thiohydantoin structure

Journal of Oral Science, 2020
The purpose of the current study was to synthesize a methacrylate monomer with a thiohydantoin structure. In a flask, (2-thiohydantoin-4-yl) propionic acid, 10-hyroxydecyl methacrylate, 4-dimethylaminopyridine, and tetrahydrofuran (THF) were placed in a nitrogen atmosphere.
Matsumura, Hideo, Kojima, Katsunori, Mio, Shigeru, Yamamoto, Takashi, Kodaira, Akihisa, Koizumi, Hiroyasu   +5 more
openaire   +3 more sources

5-(2-Methylsulfanylethyl)-3-prop-2-enyl-2-sulfanylideneimidazolidin-4-one

Molbank
An amino acid-derived 2-thiohydantoin, 5-(2-methylsulfanylethyl)-3-prop-2-enyl-2-sulfanylideneimidazolidin-4-one, obtained from l-methionine, was synthesized in a two-step reaction protocol with allyl isothiocyanate.
Petar Stanić, Marko V. Rodić, Biljana Šmit   +2 more
doaj   +1 more source

A FLUORIMETRIC ASSAY FOR MINUTE AMOUNTS OF SOME THIOHYDANTOINS

Journal of Pharmacy and Pharmacology, 1958
Abstract A fluorimetric assay sensitive to μg. quantities of certain thiohydantoins has been devised using dichloroquinone chloroimide as a fluorescence reagent. The nature of the buffer used is critical. Satisfactory results have been obtained for recoveries from urine, spinal fluid and plasma.
M E, AUERBACH, E, ANGELL
openaire   +2 more sources

IN VITRO STUDIES ON THE ANTIDIABETIC ACTIVITY OF 2-THIOHYDANTOIN USING α-amylase AND α-GLUCOSIDASE

, 2019
Objective: The aim of the present study was to investigate the inhibitory effect of 2-thiohydantoin on the enzymes α-amylase and α-glucosidase in vitro as an antidiabetic therapeutic approach to reduce gastrointestinal glucose production.
UMA S, DEVIKA PT
core  

A novel chromonyl thiohydantoin with anti-proliferative action on primary hepatocellular carcinoma cells

, 2017
Chromone, imidazolidinedione, thiohydantoin and 2,4-thiazolidinedione structures are known to be cytotoxic to cancer cells. In this study, biological activities of previously synthesized 18 chromonyl-2,4-thiazolidinediones/imidazolidinediones ...
Mehmet Ozturk, Ceylan-Unlusoy, Meltem, Ozturk, Mehmet, Ozen, Cigdem, Meltem Ceylan-Unlusoy, Oya Bozdag-Dundar, Bozdag-Dundar, Oya, Cigdem Ozen   +7 more
core   +1 more source

Organic-salt-mediated highly regioselective N3-alkylation of 2-thiophenytoin via Michael reaction under solvent-free conditions

Green Chemistry Letters and Reviews, 2016
A regioselective N3-alkylation of 5,5-diphenyl-2-thiohydantoin (2-thiophenytoin) using a very efficient mild base K2CO3 and α,β-unsaturated esters in the presence of organic salt TBAB (tetrabutylammonium bromide) at room temperature has been reported (3b–
Gholamhassan Imanzadeh, Aazam Aliabadi, Mohammadreza Zamanloo   +2 more
doaj   +1 more source

Apoptotic effects of some thiohydantoin derivatives [Bazi{dotless} Tiyohidantoin Türevlerinin Apoptotik Etkileri]

, 2010
Objectives: The aim of this study is to investigate the effects of newly synthesized 3-phenly-and 3-(4-methoxyphenyl)-2-thiohydantoin derivatives on 5RP7 ve CO25 cell apoptosis.
Akalın Çiftçi, Gülsen, Seller, Zerrin   +1 more
core  

A new polymorph of 1-acetyl-2-thiohydantoin

, 2009
The crystal structure of a new polymorph of 1-acetyl-2-thiohydantoin has been determined by X-ray diffraction. The crystal, C5H6N2O2S, belongs to space group P1 with cell dimensions of a = 4.9865(7)Å, b = 5.5716(7)Å, c = 12.544(2)Å, a = 74.793(8)°, b ...
10242538, Fujinami, Shuhei, Kuwae, Akio, 10377400, 国本, 浩喜, Taniguchi, Kazutaka, 911, 10115272, Suda, Mitsuhiro, 藤波, 修平, Maeda, Shiro, Honda, Mitsunori, 60242533, 須田, 光広, 220, 10605, 本田, 光典, 14600, 604, Okumura, Hisako, Hanai, Kazuhiko, 14603, Kunimoto, Ko-Ki, 14604, 14601, 14602   +25 more
core   +1 more source