Results 1 to 10 of about 1,063 (182)

Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea [PDF]

Beilstein Journal of Organic Chemistry, 2019
A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed.
Aleksandr I. Kobelev, Nikita A. Tretyakov, Ekaterina E. Stepanova, Maksim V. Dmitriev, Michael Rubin, Andrey N. Maslivets   +5 more
doaj   +2 more sources

Development of Novel 1,3-Disubstituted-2-Thiohydantoin Analogues with Potent Anti-Inflammatory Activity; In Vitro and In Silico Assessments [PDF]

Molecules, 2022
Inflammation is the main cause of several autoimmune diseases, including type I diabetes, rheumatoid arthritis, bullous pemphigoid, paraneoplastic pemphigoid, and multiple sclerosis.
Salma M. Khirallah, Heba M. M. Ramadan, Ahmed Shawky, Safa H. Qahl, Roua S. Baty, Nada Alqadri, Amnah Mohammed Alsuhaibani, Mariusz Jaremko, Abdul-Hamid Emwas, Essa M. Saied   +9 more
doaj   +4 more sources

A Simple Synthesis of 2-Thiohydantoins [PDF]

Molecules, 2006
2-Thiohydantoin derivatives are produced by heating a mixture of thiourea and an α-amino acid. The method described offers the advantages of simplicity, low cost, easy work-up and scalability.
Yulu Zhang, Samia O. Sheikh, Zerong Daniel Wang   +2 more
doaj   +3 more sources

Synthesis, characterization and cytotoxicity of palladium(II) complex of 3-[(2-hydroxy-benzylidene)-amino]-2-thioxo-imidazolidin-4-one [PDF]

Journal of the Serbian Chemical Society, 2013
The polydentate ligand, 3-[(2-hydroxy-benzylidene)-amino]-2-thioxo-imidazolidin-4-one, was synthesized by intermolecular cyclocondensation reaction of 2-hydroxybenzaldehyde thiosemicarbazone and ethylchloroacetate.
Šmit Biljana, Pavlović Radoslav Z., Radosavljević-Mihailović Ana, Došen Anja, Ćurčić Milena G., Šeklić Dragana S., Živanović Marko N.   +6 more
doaj   +5 more sources

In vitro assays identified thiohydantoins with anti-trypanosomatid activity and molecular modelling studies indicated possible selective CYP51 inhibition [PDF]

Scientific Reports
This work investigates the anti-trypanosomal activities of ten thiohydantoin derivatives against the parasite Trypanosoma cruzi. Compounds with aliphatic chains (THD1, THD3, and THD5) exhibited the most promising IC50 against the epimastigote form of T ...
Priscila Goes Camargo, Helena Tiemi Suzukawa, Patrícia Morais Lopes Pereira, Mariana Luiza Silva, Fernando Macedo Jr, Magaly Girão Albuquerque, Carlos Rangel Rodrigues, Sueli Fumie Yamada-Ogatta, Camilo Henrique da Silva Lima, Marcelle de Lima Ferreira Bispo   +9 more
doaj   +2 more sources

Recent Applications of Hydantoins in Drug Discovery: Updates (2019~Present) [PDF]

Molecules
Hydantoins, exemplified by the imidazolidine-2,4-dione core, are privileged scaffolds in medicinal chemistry due to their compact structure, versatile hydrogen-bonding capacity, ability to fine-tune physicochemical properties for drug-like molecules, and
Jyoti Dnyaneshwar Palkhede, Eo-Jin Park, Om Darlami, Dongyun Shin   +3 more
doaj   +2 more sources

Exploration of newly synthesized azo-thiohydantoins as the potential alkaline phosphatase inhibitors via advanced biochemical characterization and molecular modeling approaches [PDF]

BMC Chemistry
In the current study, Azo-Thiohydantoins derivatives were synthesized and characterized by using various spectroscopic techniques including FTIR, 1H-NMR, 13C-NMR, elemental and HRMS analysis. The compounds were evaluated for alkaline phosphatase activity
Hafiz Muhammad Attaullah, Syeda Abida Ejaz, Pervaiz Ali Channar, Aamer Saeed, Rabail Ujan, Seema Zargar, Sajid Ali Channar, Reshma Sahito, Tanveer A. Wani, Qamar Abbas   +9 more
doaj   +2 more sources

Synthesis of thiourea derivatives bearing the benzo[b]thiophene nucleus as potential antimicrobial agents [PDF]

Journal of the Serbian Chemical Society, 2005
The synthesis of a group of thiohydantoins and thiobarbiturates derived from 2-N-arylthiopyridocarbonyl-3,5-dichlorobenzo[b]thiophene is described. The structures of the new compounds are supported by IR, 1H-NMR and mass spectral data.
Thakar K.M., Paghdar D.J., Chovatia P.T., Joshi H.S.   +3 more
doaj   +3 more sources

Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.)

Molecules, 2021
Five new thiohydantoin derivatives (1–5) were isolated from the rhizomes of Lepidium meyenii Walp. NMR (1H and 13C NMR, 1H−1H COSY, HSQC, and HMBC), HRESIMS, and ECD were employed for the structure elucidation of new compounds.
Ranran Zhang, Junhong Liu, Hui Yan, Xingrong Peng, Ling Zhang, Minghua Qiu   +5 more
doaj   +1 more source

ANTITHYROID ACTIVITY OF THIOHYDANTOINS [PDF]

British Journal of Pharmacology and Chemotherapy, 1958
The antithyroid activity of 2‐thiohydantoin and some derivatives has been measured in rats, after a single dose and, also, after daily administration for 6 weeks. 2‐Thiohydantoin and its 5‐alkyl derivatives from 5‐methyl to 5‐sec‐butyl‐ showed considerable antithyroid activity at a dose of 0.05 m.mole/kg.
R, KILPATRICK, D T, ELMORE, D R, WOOD
openaire   +2 more sources