Results 11 to 20 of about 1,063 (182)
Angewandte Chemie, Volume 134, Issue 11, March 7, 2022., 2022 A prebiotic synthesis of the nucleobase orotate, and the citric acid cycle intermediate pyruvate, proceeds in a single pot from two small glycine derivatives, hydantoin and glyoxylate, under mild aqueous conditions. These findings support a co‐evolution of pathways to core protometabolites and nucleic acid building blocks in a common environment ...
Alyssa P. Clay +5 more
wiley +2 more sources
Fluorous Synthesis of Hydantoins and Thiohydantoins. [PDF]
ChemInform, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Wei, Zhang, Yimin, Lu
openaire +2 more sources
Kinetics and mechanism of amino acid derived 2-thiohydantoin formation reactions [PDF]
, 2022 The reaction of allyl isothiocyanate with some common natural protein amino acids (glycine, l-alanine, l-valine, l-leucine and l-phenylalanine) was monitored.
Milenkovic, Dejan +2 more
core +2 more sources
The Chemical Record, Volume 23, Issue 11, November 2023., 2023 Efforst are described for developing Brønsted base‐catalyzed, site‐ and stereoselective α‐functionalization of a variety of unsaturated enolizable carbonyl compounds via transient enolates featuring an extended π‐system. Abstract Chiral Brønsted base (BB) catalyzed asymmetric transformations constitute an important tool for synthesis.
Mikel Oiarbide, Claudio Palomo
wiley +1 more source
European Journal of Organic Chemistry, Volume 2022, Issue 40, October 26, 2022., 2022 A new strategy has been proposed for the synthesis of an array of imidazo[5,1‐c][1,4]oxazine chemotypes by using a planned aza‐Michael addition in a 3‐CR heteroring‐forming, post‐cyclization transformation followed by an intramolecular fused‐heterocycles formation process.
Giacomo Mari +4 more
wiley +1 more source
A recent update on new synthetic chiral compounds with antileishmanial activity
Chirality, Volume 34, Issue 10, Page 1279-1297, October 2022., 2022 ∎ Abstract Parasitic diseases, including malaria, leishmaniasis, and trypanosomiasis, affect billions of people and are responsible for almost 500,000 deaths/year. In particular, leishmaniasis, a neglected tropical disease, is considered a global public health problem because current drugs have several drawbacks including to toxicity, high cost, and ...
Michele Verboni +2 more
wiley +1 more source
In situ acetonitrile/water mixed solvents: An ecofriendly synthesis and structure Explanations of Cu(II), Co(II), and Ni(II) complexes of thioxoimidazolidine [PDF]
, 2021 . The bidentate oxoacetate derivative of 4-oxo-2-thiazolidine 4ligand (L1) synthesized by the reaction of 1-(1-(Pyridin-3-yl)ethylideneamino)-2-thioxoimidazolidin-4-one 3 with diethyl oxalate with both traditional and microwave irradiation methods.
A. Saad, H. +3 more
core +2 more sources
Archiv der Pharmazie, Volume 355, Issue 5, May 2022., 2022 Structurally distinct enzalutamide‐based proteolysis‐targeting chimeras (PROTACs) were designed, synthesized, and biochemically analyzed. For the first time, androgen receptor degraders were evaluated in lung cancer cells, where significant degradation of the target was observed.
Lukas M. Gockel +8 more
wiley +1 more source
Heterocyclic systems containing S/N regioselective nucleophilic competition: Facile synthesis, antitubercular and antimicrobial activity of thiohydantoins and iminothiazolidinones containing the benzo [PDF]
Journal of the Serbian Chemical Society, 2005 The required compounds N-aryl-N'-(3-chloro-2-benzo[b]thenoyl)-thioureas 1a-k were prepared by condensing 3-chloro-2-benzo[b]thenoyl chloride with different arylamines using ammonium thiocyanate, which in turn when treated with chloroacetic acid, yielded ...
Kachhadia V.V., Patel M.R., Joshi H.S.
doaj +1 more source
Progress on the Chemical Constituents Derived from Glucosinolates in Maca (Lepidium meyenii)
Natural Products and Bioprospecting, 2018 Maca (Lepidium meyenii Walp.), a famous food supplement, has drawn an unprecedented international interest over the last two decades. It was assumed that glucosinolates, macamides, macaenes, and alkaloids are the main bioactive components of Maca before.
Yan-Jie Huang +2 more
doaj +1 more source