Results 41 to 50 of about 242,358 (312)

Reversible Thiol Oxidation Inhibits the Mitochondrial ATP Synthase in Xenopus Laevis Oocytes

Antioxidants, 2020
Oocytes are postulated to repress the proton pumps (e.g., complex IV) and ATP synthase to safeguard mitochondrial DNA homoplasmy by curtailing superoxide production. Whether the ATP synthase is inhibited is, however, unknown.
James Cobley, Anna Noble, Rachel Bessell, Matthew Guille, Holger Husi   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Thermally Triggered Interface for Simplified Organic Solar Cells

Advanced Photonics Research
Organic photovoltaic (OPV) cells are commonly produced by successive printing of four layers on top of a transparent conducting electrode, with the active layer sandwiched in between interlayers followed by the top electrode.
Suwapat Kongsabay, Gilles Henri Roche, Olivier Dautel, Vinich Promarak, Guillaume Wantz   +4 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Thiol/disulfide homeostasis and oxidant status in children with congenital heart disease

Türk Biyokimya Dergisi, 2021
This article aims to explain the altered oxidative status and thiol/disulfide homeostasis before and after surgery in children with congenital heart disease (CHD).
Sogut Ibrahim, Kar Fatih, Senat Almila, Duymaz Tomris, Erel Ozcan, Salihoglu Ece   +5 more
doaj   +1 more source

Thiol Reductases in Deinococcus Bacteria and Roles in Stress Tolerance

Antioxidants, 2022
Deinococcus species possess remarkable tolerance to extreme environmental conditions that generate oxidative damage to macromolecules. Among enzymes fulfilling key functions in metabolism regulation and stress responses, thiol reductases (TRs) harbour ...
Arjan de Groot, Laurence Blanchard, Nicolas Rouhier, Pascal Rey   +3 more
doaj   +1 more source

All Hydroxyl-Thiol-Protected Gold Nanoclusters with Near-Neutral Surface Charge

, 2021
Hydrophilic gold nanoclusters (Au NCs) whose physical and chemical properties are not susceptible to large changes in pH are greatly desired for diverse applications. Here, we design Au NCs protected by a hydroxyl-thiol ligand (e.g., 1-thioglycerol (TG))
Jianping Xie, Osburg J. H. Chai, Osburg J. H. Chai (11524380), Zhennan Wu, Jianping Xie (550373), Zhennan Wu (1510228)   +5 more
core   +1 more source

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source

Evaluation of Dynamic Disulphide/Thiol Homeostasis in Silica Exposed Workers

Balkan Medical Journal, 2017
Background: Oxidative stress is implicated as one of the main molecular mechanism underlying silicosis. Aims: In this study, our aim was to asses the redox status in occupationally silica-exposed workers, by evaluating the dynamic thiol-disulphide ...
Meşide Gündüzöz, Ceylan Bal, Murat Büyükşekerci, Salim Neşelioğlu, Türkan Nadir Öziş, Servet İritaş, Halil Kara, Özcan Erel   +7 more
doaj   +1 more source