Results 91 to 100 of about 16,205 (199)

The Effectiveness of Measuring Thiopurine Metabolites in the Treatment of Autoimmune Hepatitis Patients

The Turkish Journal of Gastroenterology
Background/Aims: The thiopurine drugs—azathioprine and mercaptopurine—are purine antimetabolites used for the treatment of autoimmune hepatitis. These drugs undergo metabolism through genetically determined pathways, which influences their effectiveness ...
Woroud Yassin , Roni Nasser, Ella Veitsman, Tarek Saadi   +3 more
doaj   +1 more source

Traditional Chinese medicine combination therapy for patients with steroid-dependent ulcerative colitis: study protocol for a randomized controlled trial [PDF]

, 2017
SPIRIT 2013 Checklist: recommended items to address in a clinical trial protocol and related documents.
Hong Shen, Jia Jia, Kai Zheng, Lei Zhu, Lu Zhang, Yuelin Lu, Zhaofeng Shen   +6 more
core   +3 more sources

A Population‐Based Matched Cohort Study of Extra‐Digestive Cancer Incidence and Mortality in Individuals With and Without Inflammatory Bowel Disease

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 6, Page 859-873, March 2026.
This illustration summarises our primary findings highlighting the rising incidence of certain extra‐digestive cancers among persons with IBD over the 25‐year study duration (left), and the relative rates of extra‐digestive cancer incidence and mortality among persons with IBD in recent years (2010–2019) compared to their age‐ and sex‐matched controls (
Sanjay K. Murthy, Faria Ahmed, Michael Pugliese, Monica Taljaard, Parul Tandon, Priscilla Matthews, Gilaad G. Kaplan, Stephanie Coward, Charles N. Bernstein, Eric I. Benchimol, M. Ellen Kuenzig, Laura E. Targownik, Harminder Singh, on behalf of the Canadian Gastro‐Intestinal Epidemiology Consortium (CanGIEC)   +13 more
wiley   +1 more source

Thiopurines Induce Oxidative Stress in T-Lymphocytes: A Proteomic Approach

Mediators of Inflammation, 2015
Thiopurines are extensively used immunosuppressants for the treatment of inflammatory bowel disease (IBD). The polymorphism of thiopurine S-methyltransferase (TPMT) influences thiopurine metabolism and therapy outcome. We used a TPMT knockdown (kd) model
Misbah Misdaq, Sonia Ziegler, Nicolas von Ahsen, Michael Oellerich, Abdul R. Asif   +4 more
doaj   +1 more source

Treatment of the Pregnant Patient with Inflammatory Bowel Disease [PDF]

, 2016
Research regarding fertility, medication safety, and pregnancy outcomes is increasing, but there are still many knowledge gaps in these areas.
Friedman, Sonia, Nørgård, Bente M, Winter, Rachel   +2 more
core   +2 more sources

Induction Therapy With Oral Tacrolimus Provides Long‐Term Benefit in Thiopurine‐Naïve Refractory Ulcerative Colitis Patients Despite Low Serum Albumin Levels

JGH Open
Background and Aim Oral tacrolimus is an effective treatment for refractory ulcerative colitis (UC). However, tacrolimus is underutilized because of the difficulties in transitioning to subsequent maintenance therapy and concerns about adverse events ...
Shoko Igawa, Toshihiro Inokuchi, Sakiko Hiraoka, Junki Toyosawa, Yuki Aoyama, Yasushi Yamasaki, Hideaki Kinugasa, Masahiro Takahara, Hiroyuki Okada, Motoyuki Otsuka   +9 more
doaj   +1 more source

Analytical Validation of Variants to Aid in Genotype-Guided Therapy for Oncology [PDF]

, 2019
The Clinical Laboratory Improvement Amendments (CLIA) of 1988 requires that pharmacogenetic genotyping methods need to be established according to technical standards and laboratory practice guidelines before testing can be offered to patients.
Kiel, Patrick J., Medeiros, Elizabeth B., Pratt, Victoria M., Schneider, Bryan P., Shen, Fei, Skaar, Todd C., Stansberry, Wesley M., Swart, Marelize   +7 more
core   +1 more source

Impact of NUDT15 polymorphisms on thiopurines-induced myelotoxicity and thiopurines tolerance dose

Oncotarget, 2017
Thiopurines are widely used as anticancer and immunosuppressive agents. However, life-threatening myelotoxicity has been noticed and largely explained by genetic variations, including NUDT15 polymorphisms (e.g., rs116855232). In this study, we conduct a meta-analysis to investigate the impact of rs116855232 on thiopurines-induced myelotoxicity ...
Yin, Dandan, Xia, Xuyang, Zhang, Junlong, Zhang, Shouyue, Liao, Fei, Zhang, Ge, Zhang, Yan, Hou, Qianqian, Yang, Xue, Wang, Hong, Ma, Zhigui, Wang, Heyao, Zhu, Yiping, Zhang, Wei, Wang, Yuelan, Liu, Bo, Wang, Lanlan, Xu, Heng, Shu, Yang   +18 more
openaire   +3 more sources

Thiopurine S-methyltransferase polymorphisms in acute lymphoblastic leukemia, inflammatory bowel disease and autoimmune disorders: influence on treatment response

Pharmacogenomics and Personalized Medicine, 2017
Rachid Abaji,1 Maja Krajinovic2 1Department of Pharmacology, 2Departments of Pediatrics and Pharmacology, CHU Sainte-Justine Research Center, University of Montreal, Montreal, QC, Canada Abstract: The thiopurine S-methyltransferase (TPMT) gene encodes ...
Abaji R, Krajinovic M
doaj  

Individualized immunosuppression in transplant patients: potential role of pharmacogenetics. [PDF]

, 2012
The immunosuppressive drugs used to prevent the rejection of transplanted organs have a narrow therapeutic index. Under treatment results in episodes of rejection leading to either damage or loss of the organ. Over immunosuppression increases the risk of
Abboudi, H, Macphee, IA
core   +2 more sources